Compartment Syndrome Recognition
High-Risk Injuries
- Supracondylar humerus fractures: 5-30% incidence with vascular injury (highest risk pediatric)
- Both-bone forearm fractures: Especially high-energy, displacement, fracture manipulation
- Crush injuries: Direct forearm compression, prolonged extrication
- Arterial injection injuries: Intra-arterial drug injection causing chemical injury and swelling
- Reperfusion after vascular repair: Ischemia >4-6 hours followed by revascularization
- Burns: Circumferential or deep burns causing eschar constriction
Clinical Signs (5 Ps - Late Findings)
- Pain: Out of proportion to injury (earliest and most reliable sign)
- Pressure: Forearm rock-hard, tense on palpation
- Passive stretch pain: Extension of fingers (volar), flexion (dorsal) - MOST SENSITIVE TEST
- Paresthesias: Median/ulnar distribution (intrinsic minus positioning)
- Pulselessness: LATE sign - pulses often present due to collateral circulation
- Pallor: LATE sign indicating advanced ischemia
- Paralysis: LATE sign - indicates muscle/nerve damage already occurring
Exam Pearl
Critical Concept: Radial and ulnar pulses can remain palpable even with established compartment syndrome due to extensive forearm collateral circulation. NEVER wait for pulselessness. Pain on passive finger extension (stretching volar flexors) is the most sensitive clinical test. Delay beyond 6-8 hours risks irreversible Volkmann's contracture.
Pressure Measurement (When Diagnosis Uncertain)
- Indications: Unconscious patient, uncooperative pediatric patient, obtunded, equivocal exam
- Technique: Insert needle perpendicular to fascia at zone of maximal swelling
- Compartments to measure: Superficial volar, deep volar, dorsal, mobile wad
- Thresholds:
- Absolute pressure >30mmHg = fasciotomy indicated
- Delta pressure <30mmHg (diastolic BP minus compartment pressure) = fasciotomy indicated
- Pediatric: Some use >20mmHg absolute or delta <40mmHg (more conservative)
- Normal: 0-8mmHg resting compartment pressure
Clinical Diagnosis Paramount
Do NOT delay surgery for pressure measurements when clinical diagnosis clear. Compartment syndrome is primarily a CLINICAL diagnosis. High-risk injury (supracondylar with vascular compromise) + pain on passive stretch = emergent fasciotomy regardless of pressure measurements.
Neurovascular Baseline Documentation
Document pre-operative status:
- Median nerve: APB strength (thumb opposition), sensation thumb/index/middle finger
- Ulnar nerve: Interossei/ADM strength, sensation small/ring finger
- Radial nerve: Wrist/finger/thumb extension, first web space sensation
- AIN: FPL and index FDP (pinch strength) - purely motor
- Vascular: Radial pulse, ulnar pulse, capillary refill, hand perfusion
Four Compartment Anatomy
Superficial Volar Compartment
Contents:
- Pronator teres (most proximal and radial)
- Flexor carpi radialis (FCR)
- Palmaris longus (PL) - absent in 15%
- Flexor carpi ulnaris (FCU)
- Flexor digitorum superficialis (FDS) - deep layer
- Median nerve (passes between two heads of FDS ~4cm distal to elbow)
Fascial boundaries: Distinct investing fascia, thickest distally near wrist
Release technique: Volar incision, longitudinal fasciotomy from elbow to wrist
Deep Volar Compartment
Contents:
- Flexor digitorum profundus (FDP) - four tendons to digits (ulnar side)
- Flexor pollicis longus (FPL) - single tendon to thumb (radial side)
- Pronator quadratus (PQ) - square muscle in distal forearm
- Anterior interosseous nerve (AIN) - branches from median 5-8cm distal to elbow
- Anterior interosseous artery and vein
Access: Elevate FDS and superficial muscles radially to expose deep compartment
Critical structure: AIN runs on interosseous membrane - essential for pinch
Mobile Wad (Radial Compartment)
Contents:
- Brachioradialis (BR) - most superficial and radial
- Extensor carpi radialis longus (ECRL)
- Extensor carpi radialis brevis (ECRB)
- Superficial radial nerve (sensory) - runs under BR, emerges 9cm proximal to radial styloid
- Radial artery - runs under BR proximally, emerges between BR and FCR distally
Unique feature: Can be released from volar OR dorsal approach. Many surgeons release from both.
Dorsal (Extensor) Compartment
Contents:
- Superficial layer: EDC, EDM, ECU
- Deep layer: Supinator, APL, EPB, EPL, EIP
- Posterior interosseous nerve (PIN) - deep branch of radial nerve
- Posterior interosseous artery
PIN course: Penetrates supinator through arcade of Frohse (~5cm distal to lateral epicondyle), innervates all extensors
Release technique: Dorsal longitudinal incision, release including supinator fascia
Compartments requiring release
Incisions needed (volar + dorsal)
Major nerves at risk
Major arteries at risk
Step-by-Step Technique
Initial Assessment and Setup
Patient Position:
- Supine, arm on radiolucent arm board
- Shoulder abducted 80-90 degrees
- Forearm supinated for volar approach (then pronate for dorsal)
- Tourniquet applied to upper arm but NOT inflated (need to assess perfusion)
Preparation:
- Entire upper extremity prepared shoulder to fingertips
- Drape to allow arm repositioning
- Have vascular surgery available if arterial injury suspected
VOLAR APPROACH - Steps 1-8
Step 1: Volar Incision (Curvilinear/Zigzag)
Incision design:
- Start 2cm distal to antecubital flexion crease on ULNAR side
- Curve distally in lazy-S pattern crossing volar wrist in ZIGZAG (Z-plasty configuration)
- Extend into palm toward ring finger web space if releasing carpal tunnel
- NEVER use straight-line incision across wrist crease (causes flexion contracture)
Subcutaneous dissection:
- Incise skin and subcutaneous tissue
- Preserve visible veins (basilic, cephalic, median forearm)
- Identify and PRESERVE medial and lateral antebrachial cutaneous nerves (forearm sensation)
Exam Pearl
Critical Technical Point: Zigzag crossing of wrist crease is mandatory. Straight-line incision causes severe flexion contracture from scar contracture across joint. The Z-plasty distributes tension across multiple vectors and allows skin closure or grafting.
Step 2: Release Lacertus Fibrosus
Proximal structures:
- Identify biceps tendon (central)
- Identify brachial artery (medial to biceps, palpable pulse)
- Identify median nerve (1cm medial to brachial artery, yellow cord)
- Identify brachioradialis muscle (lateral, forms radial border of antecubital fossa)
Lacertus fibrosus division:
- Thick fascial band extending from biceps tendon medially
- Crosses over brachial artery and median nerve
- MUST be divided to decompress neurovascular structures
- Use scissors to divide under direct vision
Median Nerve Protection
Median nerve is 1cm medial to brachial artery in antecubital fossa. Identifiable as yellow cord. Avoid traction, retract gently. Nerve dives between two heads of FDS distally (~4cm from elbow crease) - most vulnerable point.
Step 3: Superficial Volar Compartment Release
Fascial incision:
- Incise investing fascia over superficial flexors longitudinally
- Extend from elbow to wrist (full length decompression)
- Release pronator teres origin from medial epicondyle if tense
Contents exposed:
- Pronator teres (radial, proximal)
- FCR (radial)
- Palmaris longus (central - may be absent)
- FCU (ulnar)
- FDS (deep layer - protect median nerve between heads)
Adequacy check: Muscles should BULGE through fasciotomy. Palpate - should be soft.
Step 4: Deep Volar Compartment Release
Access technique:
- Elevate FDS and superficial muscle group radially
- Expose deep compartment (FDP ulnar side, FPL radial side)
- Identify anterior interosseous nerve on interosseous membrane
Fascial release:
- Incise fascia over FDP and FPL longitudinally
- Release FDP origin from ulna if tense
- Protect AIN throughout - avoid direct manipulation
AIN anatomy:
- Branches from median nerve 5-8cm distal to elbow
- Runs on anterior surface of interosseous membrane
- Innervates FPL, radial FDP (index/middle), pronator quadratus
- Purely motor (no sensory component)
Exam Pearl
AIN Preservation: AIN is critical for pinch function (FPL). Injury causes inability to flex thumb IP joint. Identify on interosseous membrane. If transected, immediate repair required. If contused from ischemia, may recover in 8-12 weeks.
Step 5: Mobile Wad Release (from volar side)
Identification:
- Brachioradialis is most radial structure (superficial)
- ECRL deep to BR
- ECRB deepest
Radial artery location:
- Runs UNDER brachioradialis in proximal-mid forearm
- Emerges between BR and FCR at junction middle/distal third
- Palpable pulse distally
Superficial radial nerve:
- Sensory branch of radial nerve
- Runs under brachioradialis
- Emerges ~9cm proximal to radial styloid
- Injury causes dysesthesias dorsal thumb/hand
Release: Incise fascia over mobile wad muscles. Often also released from dorsal side for complete decompression.
Step 6: Carpal Tunnel Release (Prophylactic)
Rationale: Prevent intrinsic muscle ischemia and median neuropathy from hand swelling
Technique:
- Extend volar incision into palm toward ring finger web space (ulnar-midline direction)
- Avoids recurrent motor branch which goes radially to thenar
- Incise transverse carpal ligament under direct vision
- Release from distal (mid-palm where median branches) to proximal (arcuate ligament at wrist)
- Protect median nerve (deep to TCL) and motor branch (radial at distal TCL)
Controversy: Some surgeons release routinely, others selectively based on hand symptoms/swelling
Motor Branch Protection
Recurrent motor branch of median nerve branches radially at distal edge of transverse carpal ligament. Innervates thenar muscles (APB, opponens, superficial FPB). Injury causes thenar weakness and inability to oppose thumb. Incision toward ring finger (ulnar-midline) avoids this structure.
Step 7: Confirm Volar Compartment Decompression
Systematic check:
- Superficial volar: Should bulge, palpate - soft
- Deep volar: Should bulge when FDS elevated, palpate - soft
- Mobile wad: Released from volar (will also release from dorsal)
Inadequate release signs:
- Muscle not bulging
- Compartment still tense/firm on palpation
- Persistent fascial bands
Action: Extend fascial releases, ensure full proximal-to-distal decompression
DORSAL APPROACH - Steps 8-11
Step 8: Dorsal Incision (Longitudinal)
Positioning: Pronate forearm
Incision:
- Longitudinal from lateral epicondyle to Lister's tubercle
- Position over mobile wad/radial border of extensor compartment
- Lister's tubercle is palpable dorsal radial landmark at wrist (EPL runs around ulnar side)
Subcutaneous dissection:
- Incise skin and subcutaneous tissue
- Superficial radial nerve dorsal sensory branches emerge 9cm proximal to radial styloid
- MUST identify and protect - injury causes painful dysesthesias and numbness
Exam Pearl
Superficial Radial Nerve: Dorsal sensory branches emerge from under brachioradialis approximately 9cm proximal to radial styloid. Multiple small branches provide sensation to dorsal thumb, index, and radial hand. Injury causes burning dysesthesias - very problematic for patients.
Step 9: Mobile Wad Release (from dorsal side)
Identification from dorsal:
- BR most superficial and radial
- ECRL deep to BR
- ECRB deepest (adjacent to extensors)
Complete release: Combined volar and dorsal release ensures complete mobile wad decompression
Check: Mobile wad should bulge from both volar and dorsal wounds
Step 10: Dorsal Extensor Compartment Release
Fascial incision:
- Incise fascia over extensor muscles longitudinally
- Extend from proximal forearm to extensor retinaculum at wrist
- Release supinator fascia proximally (decompresses PIN at arcade of Frohse)
Contents:
- Superficial layer: EDC, EDM, ECU
- Deep layer: Supinator (proximal), APL, EPB, EPL, EIP
- Posterior interosseous nerve (in supinator, then between superficial and deep layers)
PIN anatomy:
- Deep branch of radial nerve
- Penetrates supinator through arcade of Frohse ~5cm distal to lateral epicondyle
- Innervates ALL finger and thumb extensors
- Injury causes finger/thumb drop (devastating functional loss)
PIN Protection
PIN is vulnerable in proximal dorsal compartment where it penetrates supinator. Must release supinator fascia to decompress arcade of Frohse. Avoid deep dissection in proximal compartment. PIN injury causes complete finger and thumb extension paralysis.
Step 11: Confirm Complete Four-Compartment Release
Systematic verification - ALL four compartments:
- Superficial volar: Bulging from volar wound, soft on palpation
- Deep volar: Bulging when FDS elevated, soft on palpation
- Mobile wad: Bulging from BOTH volar and dorsal wounds, soft
- Dorsal extensor: Bulging from dorsal wound, soft on palpation
Test: Run finger along each fascial release proximally to distally - should be continuous decompression without bands
If tense: Extend releases, ensure distal decompression (fasciae thickest at wrist)
Muscle bulge expected
Compartment on palpation
Compartments released
ASSESSMENT AND CLOSURE - Steps 12-15
Step 12: Muscle Viability Assessment (4 Cs)
Apply 4 Cs criteria to all compartments:
-
Color:
- Pink = viable
- Pale/dusky = questionable
- Black/purple/grey = necrotic
-
Contractility:
- Gently squeeze or stimulate with forceps
- Should contract if viable
- No contraction = necrotic
-
Consistency:
- Firm = viable
- Soft/mushy = necrotic
-
Capacity to bleed:
- Cut edge should ooze blood
- No bleeding = non-viable
Management decisions:
- Clearly necrotic (black, mushy, no contractility, no bleeding): Debride to prevent myonephropathic syndrome
- Questionable viability: LEAVE and reassess at second look in 48 hours (avoid over-resection)
- Viable muscle: Leave alone
Exam Pearl
Debridement vs Preservation Balance: Necrotic muscle MUST be debrided to prevent rhabdomyolysis, myoglobinuria, hyperkalemia, and acute renal failure. However, forearm muscle loss causes devastating functional deficit. For questionable muscle, leave and reassess at second look rather than over-debride. Document viability assessment thoroughly.
Step 13: Neurovascular Re-examination
Vascular assessment:
- Radial pulse
- Ulnar pulse
- Digital capillary refill
- Doppler signals if pulses not palpable
- Improved perfusion expected after decompression
- If no pulses despite decompression → suspect arterial injury requiring vascular exploration
Neurologic assessment:
- Median: APB strength, thumb/index/middle sensation
- Ulnar: Interossei/ADM strength, small/ring sensation
- Radial: Wrist/finger/thumb extension, first web sensation
- AIN: Pinch (FPL and index FDP)
- PIN: Finger/thumb extension
Expected findings:
- Vascular: Improvement in perfusion
- Neurologic: May NOT immediately improve (neurapraxia from ischemia takes 6-12 weeks recovery)
Document: Complete neurovascular exam for medicolegal record and future comparison
Step 14: Hemostasis and Irrigation
Hemostasis:
- Skin edges only - use electrocautery judiciously
- Do NOT cauterize muscle (causes further necrosis)
- Direct pressure for muscle bleeding
- Never blind clamp vessels (nerve injury risk)
Irrigation:
- Copious saline irrigation all wounds
- Remove debris, hematoma, necrotic tissue fragments
Step 15: Wound Management (NEVER Close Primarily)
Critical principle: NEVER close fasciotomy wounds primarily → causes recurrent compartment syndrome
Dressing options:
-
Moist dressings:
- Saline-soaked gauze
- Dilute betadine (0.25%) soaked gauze
- Bulky absorbent outer layer
- Change daily
-
Negative pressure wound therapy (VAC):
- Controls edema
- Promotes granulation
- Reduces infection risk
- Change every 48-72 hours
- Preferred by many surgeons
Splinting:
- Volar splint maintaining wrist in neutral
- Fingers FREE for monitoring
- Avoid circumferential dressings/splints (can recreate compartment syndrome)
Elevation: Arm elevated to heart level (not above - reduces perfusion)
Never Primary Closure
Primary closure of fasciotomy wounds causes recurrent compartment syndrome and is never performed. Wounds left completely open with moist dressings or VAC therapy. Definitive closure planned at second look (48-72 hours) based on edema resolution and muscle viability.
Immediate Post-operative Management
Monitoring Protocol
- Neurovascular checks: Q2 hours x 24 hours, then Q4 hours
- Monitor: Radial/ulnar pulses, capillary refill, finger sensation/motion, pain level
- Compartment reassessment: Palpate through dressing for tension
- Signs of recurrent compartment syndrome: Increasing pain, tense forearm despite open wounds
Medical Management
If muscle necrosis present - Prevent myonephropathic syndrome:
- Aggressive IV hydration: Target urine output 1-2 ml/kg/hour
- Alkalinize urine: Sodium bicarbonate (prevent myoglobin precipitation in renal tubules)
- Monitor labs:
- CK (creatine kinase) - markedly elevated if muscle necrosis
- Myoglobin (serum and urine)
- Creatinine (renal function)
- Potassium (hyperkalemia from muscle breakdown)
- Calcium (hypocalcemia from calcium deposition in necrotic muscle)
- Dialysis: If acute renal failure develops (10-30% with severe muscle necrosis)
Antibiotics:
- Coverage for skin flora (Staph, Strep)
- Broad spectrum if contaminated injury
- Adjust based on cultures
DVT prophylaxis:
- Sequential compression devices
- Chemical prophylaxis when bleeding risk acceptable
Pain control:
- Adequate analgesia
- Avoid masking compartment syndrome symptoms in early post-op period
Dressing Changes
- Moist dressings: Change daily in ward
- VAC therapy: Change every 48-72 hours (in OR or bedside depending on patient tolerance)
- Assess: Wound appearance, drainage, odor (infection signs)
Second Look Procedure (48-72 hours)
Indications for Second Look
- ALL forearm fasciotomy patients
- Reassess muscle viability
- Debride necrotic tissue
- Plan definitive wound closure
Second Look Assessment
Muscle viability re-evaluation (4 Cs again):
- Color: Pink viable, black necrotic
- Contractility: Stimulate - should contract
- Consistency: Firm viable, mushy necrotic
- Capacity to bleed: Should ooze from cut edge
Debridement:
- Remove clearly necrotic muscle
- Preserve all questionable muscle that shows any viability
- Send tissue for culture if infection suspected
- Radical debridement may require repeat second look
Neurovascular reassessment:
- Pulses should be present if initially ischemic
- Nerve function may show early recovery (or may take weeks)
- If persistent vascular compromise → vascular surgery consult
Definitive Wound Closure Options
Option 1: Delayed Primary Closure (10-15% of cases)
- Indications: Minimal edema, wounds approximate easily, healthy muscle
- Timing: 3-5 days post-fasciotomy
- Technique: Approximation without tension, may need relaxing incisions
- Outcomes: Best cosmetic result, lowest morbidity
- Limitations: Rarely achievable due to skin tension
Option 2: Split-Thickness Skin Graft (STSG) (60-80% of cases)
- Indications: Cannot approximate, healthy granulation, no exposed vital structures
- Timing: 5-7 days (wait for granulation)
- Donor site: Thigh (anterior/lateral)
- Technique:
- 0.010-0.012 inch thickness
- Meshed 1.5:1 or 2:1 (allows expansion and drainage)
- Bolster dressing x 5-7 days
- Outcomes: Reliable coverage, acceptable cosmesis
- Volar wrist challenge: Most difficult area to close due to skin tension - often requires STSG
Option 3: Flap Coverage (5-10% of cases)
- Indications: Exposed tendons, nerves, or bone requiring vascularized coverage
- Options:
- Local fasciocutaneous flaps
- Radial forearm flap (if radial artery intact and not needed)
- Free tissue transfer (for large defects)
- Timing: Urgent if exposed vital structures
- Outcomes: Provides durable coverage but increased morbidity
Option 4: Serial Debridement (if persistent necrosis)
- Return to OR every 48-72 hours
- Continue debridement until healthy tissue bed
- Then proceed to STSG or flap as above
Exam Pearl
Volar Wrist Closure Challenge: The volar wrist incision is the most difficult to close due to skin tension across wrist flexion crease. Rarely achievable with delayed primary closure. Most require STSG. Zigzag incision design helps but tension still significant. Plan for STSG from initial surgery.
Rehabilitation Protocol
Phase 1: Protection (Weeks 0-2)
- Splint in neutral wrist position
- Fingers free for monitoring and gentle ROM
- Wound care primary focus
- Gentle passive ROM when wounds stable
Phase 2: Early Mobilization (Weeks 2-6)
- Active ROM all joints
- Gentle stretching
- Edema control (compression, elevation)
- Scar massage once wounds healed
Phase 3: Strengthening (Weeks 6-12)
- Progressive resistance exercises
- Functional activities
- Continued stretching to prevent contracture
- Splinting at night if developing contracture
Phase 4: Advanced Rehabilitation (Months 3-6)
- Work-specific activities
- Sport-specific training
- Maximize ROM and strength
- Address persistent stiffness aggressively
Expected outcomes:
- Full recovery: 40-60% if early fasciotomy (<6 hours)
- Partial recovery: 30-40% (some stiffness/weakness)
- Poor outcome: 10-20% (established Volkmann's contracture if delayed >8 hours)
Predictors of poor outcome:
- Delayed fasciotomy (>8 hours from onset)
- Muscle necrosis requiring debridement
- Concomitant nerve injury
- Infection
- Patient non-compliance with therapy
Long-term Follow-up
Clinic Visits
- Week 2: Wound check, suture removal from STSG donor
- Week 6: Assess ROM, strength, nerve recovery
- Month 3: Functional assessment
- Month 6: Final evaluation
- Year 1: Long-term outcome assessment
Assessments
- ROM: Wrist flexion/extension, finger flexion/extension, forearm rotation
- Strength: Grip, pinch, individual muscle testing
- Nerve recovery: Sensation (2-point discrimination), motor (MRC grading)
- Functional scores: DASH, QuickDASH, PROMIS
- Return to work: Average 3-6 months depending on occupation
Late Complications to Monitor
- Chronic stiffness/contracture → ongoing therapy, possible capsulotomy
- Neuropathic pain → gabapentin, pregabalin, pain management referral
- Cold intolerance → common, educate patient
- Unsightly scars → scar revision after 1 year if desired
- Chronic regional pain syndrome → aggressive PT, sympathetic blocks
Intraoperative Complications
Neurovascular Injury (5-15%)
Structures at risk:
- Median nerve (most common - between FDS heads)
- Anterior interosseous nerve (deep volar compartment)
- Ulnar nerve (ulnar border deep dissection)
- Radial artery (under brachioradialis, mobile wad release)
- Ulnar artery (ulnar border)
- Superficial radial nerve (dorsal approach, mobile wad)
- Posterior interosseous nerve (dorsal compartment, supinator)
Prevention:
- Identify nerves before releasing overlying fascia
- Gentle retraction with vessel loops
- Longitudinal fascial incisions parallel to nerve courses
- Avoid cautery near neurovascular structures
- Direct pressure (not blind clamping) for vascular control
Management if injury occurs:
- Nerve laceration: Immediate repair with 8-0 or 9-0 nylon under microscope
- Nerve contusion: Document, observe for recovery
- Arterial laceration: Vascular repair vs ligation (radial can ligate if ulnar intact)
Incomplete Compartment Release (10-20%)
Causes:
- Missing a compartment (commonly deep volar or mobile wad)
- Inadequate distal release (wrist level where fasciae thickest)
- Residual fascial bands
Recognition:
- Compartment still tense on palpation
- Muscle not bulging through fasciotomy
- Persistent pain post-operatively
Management:
- Immediate re-exploration and complete release
- Systematically verify all four compartments soft and bulging
Excessive Bleeding
Sources:
- Muscle (do not cauterize - direct pressure)
- Skin edges (cauterize sparingly)
- Arterial injury (control, repair if major vessel)
Management:
- Hemostasis without tourniquet (assess perfusion)
- Direct pressure
- Judicious cautery
- Transfusion if needed
Early Post-operative Complications (Days to Weeks)
Recurrent/Persistent Compartment Syndrome (2-5%)
Causes:
- Incomplete initial release
- Tight dressings/splints
- Primary closure attempt (never do this)
- Reperfusion injury and massive swelling
Recognition:
- Increasing pain despite open fasciotomy
- Tense forearm on palpation through dressing
- Pain on passive finger motion
- Neurovascular deterioration
Management:
- Remove dressings/splints immediately
- Re-examine compartments
- Return to OR for revision fasciotomy if inadequate initial release
Infection (15-25%)
Risk factors:
- Open wounds
- Contaminated injury
- Necrotic muscle
- Delayed presentation
- Immunocompromised
Prevention:
- IV antibiotics
- Thorough irrigation
- Debridement of necrotic tissue
- Frequent dressing changes or VAC
Management:
- Cultures (wound, tissue, blood)
- Broad-spectrum antibiotics adjusted by culture
- Surgical debridement if abscess/necrosis
- May require multiple debridements
Myonephropathic Metabolic Syndrome (10-30% if severe)
Pathophysiology: Massive muscle necrosis → rhabdomyolysis → myoglobinuria → acute tubular necrosis → renal failure
Clinical features:
- Dark urine (myoglobinuria - tea or cola colored)
- Oliguria, anuria
- Hyperkalemia (from cell breakdown)
- Hypocalcemia (calcium deposits in necrotic muscle)
- Metabolic acidosis
- Elevated CK (often >10,000-50,000+ U/L)
Prevention:
- Early fasciotomy (prevent muscle necrosis)
- Debride necrotic muscle
- Aggressive IV hydration
- Urine alkalinization
Management:
- ICU monitoring
- Aggressive IV hydration (target UOP 1-2 ml/kg/hr)
- Sodium bicarbonate (urine pH >6.5 prevents myoglobin precipitation)
- Treat hyperkalemia (insulin/glucose, calcium, kayexalate, dialysis if severe)
- Dialysis if acute renal failure
- Mortality 5-10% if develops renal failure
Wound Necrosis (10-20%)
Causes:
- Excessive skin undermining
- Tight sutures at delayed primary closure
- Vascular compromise
- Infection
Management:
- Debride necrotic skin edges
- Convert to STSG coverage
Late Complications (Weeks to Months)
Volkmann's Ischemic Contracture (5-30% depending on delay)
Definition: Irreversible flexion contracture from muscle fibrosis after prolonged ischemia
Grading (Tsuge/Seddon):
- Mild: Flexion contracture of 2-3 fingers (usually middle/ring), wrist flexion OK, intrinsics OK
- Moderate: All fingers flexed, wrist flexed, some intrinsic weakness, sensory deficit
- Severe: All muscles (flexors, extensors, intrinsics) fibrotic, severe contracture, claw hand, sensory loss
Prevention: Early fasciotomy (<6-8 hours from onset)
Management:
- Mild: Stretching, splinting, possible flexor slide procedure
- Moderate: Flexor slide (separate fibrotic muscle origins), tendon lengthening, capsulotomies
- Severe: Muscle excision and free functioning muscle transfer (gracilis), or amputation if non-functional
Prognosis: Devastating complication. Full functional recovery rare once contracture established.
Exam Pearl
Volkmann's Contracture Prevention: The reason for urgent fasciotomy. Ischemia >6-8 hours leads to irreversible muscle necrosis and fibrosis. Results in crippling flexion contracture. Prevention is the only effective treatment - operative urgency cannot be overstated.
Chronic Stiffness (40-60%)
Affected joints: Wrist, fingers, elbow, forearm rotation
Causes:
- Prolonged immobilization
- Muscle/tendon adhesions
- Capsular contracture
- Patient non-compliance with therapy
Management:
- Aggressive hand therapy
- Dynamic splinting
- Capsulotomy or tenolysis if plateau after 6 months therapy
Nerve Deficits (20-40%)
Types:
- Neurapraxia: From ischemia, usually recovers 6-12 weeks
- Iatrogenic injury: Partial or complete laceration
- Chronic compression: From scar, may require neurolysis
Management:
- Neurapraxia: Observation, therapy, consider EMG/NCS at 6 weeks
- Complete laceration: Nerve graft or transfer if not repaired primarily
- Chronic compression: Neurolysis, possible nerve grafting
Chronic Regional Pain Syndrome (CRPS) (5-10%)
Clinical features:
- Burning pain out of proportion
- Allodynia, hyperesthesia
- Temperature/color changes
- Edema, sweating abnormalities
- Dystrophic skin changes
Management:
- Aggressive hand therapy (most important)
- Gabapentin or pregabalin
- Sympathetic blocks
- Dorsal column stimulator (refractory cases)
- Prognosis better if early recognition and treatment
Skin Graft Complications (in 60-80% requiring STSG)
Graft failure (5-10%):
- Hematoma/seroma under graft
- Infection
- Excessive motion
Poor cosmesis: Acceptable trade-off for functional limb
Donor site issues:
- Delayed healing
- Pain
- Hypertrophic scarring
- Pigmentation changes