Supine | Two Windows | Brachialis Protects the Radial Nerve
- Supine position with the whole humerus visible to fluoroscopy in AP and lateral
- Two incisions only β a proximal deltopectoral and a distal anterolateral window; the fracture haematoma is never touched
- The brachialis is the key protective layer β splitting it leaves a lateral cuff shielding the radial nerve
- Submuscular extrasynovial tunnelling of a long pre-contoured bridge plate preserves biology
- Indirect reduction restores length, alignment and rotation; the plate is a reduction tool, not an anatomic clamp
When & Why
What it exposes. The anterior MIPO corridor delivers a long submuscular bridge plate to the humeral shaft through two small windows β a proximal deltopectoral window and a distal anterolateral window β joined by an extrasynovial, epiperiosteal tunnel on the anterior cortex, with no direct exposure of the fracture. Primary indications: - Comminuted or segmental humeral shaft fractures where biological preservation favours bridge plating over rigid compression
- Unstable shaft fractures unsuitable for non-operative management (shortening, angulation, displacement, or failure of functional bracing)
- Pathological or impending pathological fractures of the humeral diaphysis
- Polytrauma where early definitive or damage-control stabilisation is desirable
- Selected open fractures with soft-tissue compromise where long extensile incisions are best avoided
- Paediatric and adolescent humeral shaft fractures in selected cases where fixation is indicated Why this approach is chosen. MIPO respects the biological environment at the fracture by avoiding direct exposure of the fracture haematoma and the soft-tissue attachments. A long plate is slid through two small windows along the anterior humeral surface, which is broad, relatively flat and largely submuscular. This delivers a long, elastic bridge construct that distributes strain and supports indirect healing, in contrast to open plating (which strips biology) or intramedullary nailing (which carries distinct shoulder entry-point and radial-nerve considerations). Contraindications: - Intra-articular extension requiring direct open reduction (use a formal articular approach instead)
- Active wound infection or gross contamination over the planned windows (until controlled)
- Fracture patterns where the radial nerve is interposed between fragments and must be directly visualised (some surgeons prefer a posterior approach with nerve identification)
- Vascular injury requiring open exploration and repair
- Inability to obtain adequate fluoroscopic imaging of the whole humerus intra-operatively
| Method | Approach | Biology at fracture | Key trade-off |
|---|---|---|---|
| Functional bracing | Non-operative | Maximal | Needs a compliant patient and acceptable alignment |
| MIPO bridge plating | Two small windows, supine | Preserved | Fluoroscopic; radial nerve caution |
| Intramedullary nailing | Closed, shoulder entry | Preserved | Shoulder pain and rotator cuff entry morbidity |
| Open ORIF | Formal exposure | Reduced | Direct visualisation, higher soft-tissue insult |
Position & landmarks. The supine position is central to the anterior MIPO corridor. Place the patient supine on a radiolucent table with a small bolster under the ipsilateral scapula to bring the arm forward, and rest the arm on a radiolucent armboard or across the chest on a sterile bolster. The aim is unobstructed fluoroscopic visualisation of the entire humerus in AP and lateral β confirm both views before draping. A well-padded tourniquet is used only if it will not obstruct plate length or imaging; many surgeons operate without one. Proximal window landmarks: the coracoid process (palpable guide to the deltopectoral interval), the anterolateral corner of the acromion (proximal extent for a deltoid-splitting variant), the deltopectoral groove containing the cephalic vein, and the long head of biceps tendon in the intertubercular groove. Distal window landmarks: the biceps brachii muscle belly and tendon (the medial boundary, retracted medially), the lateral supracondylar ridge and lateral epicondyle, the mobile wad (brachioradialis and extensor carpi radialis longus and brevis) marking where the radial nerve lies, and the brachialis filling the interval between biceps and the lateral musculature.
The Exposure
Work from two windows remote from the fracture, develop an internervous plane at each, and join them with a submuscular tunnel on the anterior cortex. The broad, flat anterior humeral surface is the plate-bearing surface, and the brachialis is the muscular buffer that shields the radial nerve throughout.
| Layer | Muscle | Nerve supply | Role in the approach |
|---|---|---|---|
| Proximal | Deltoid | Axillary nerve | Retracted laterally in the proximal window |
| Proximal | Pectoralis major | Lateral pectoral nerve | Retracted medially in the proximal window |
| Anterior | Biceps brachii | Musculocutaneous nerve | Retracted medially in the distal window |
| Anterior (deep) | Brachialis | Musculocutaneous and radial nerves | Split in its mid-substance β the lateral half protects the radial nerve |
| Lateral (distal) | Brachioradialis and ECRL | Radial nerve | Marks the lateral border near the radial nerve |
Two internervous planes, one tunnel. The proximal window uses the deltopectoral interval β deltoid (axillary nerve) versus pectoralis major (pectoral nerves). The distal window runs between biceps (musculocutaneous nerve), retracted medially, and the underlying brachialis; the brachialis is then split longitudinally to bone. This split is safe because the brachialis has dual innervation β the medial half from the musculocutaneous nerve and the lateral half from the radial nerve β so neither half is denervated. Leaving the lateral half of brachialis attached interposes muscle between the plate and the radial nerve, which lies further lateral, between brachialis and brachioradialis.
Intra-operative photograph or fluoroscopic sequence of anterior MIPO of the humeral shaft: two small incisions (proximal deltopectoral and distal anterolateral), a long bridge plate tunnelled submuscularly on the anterior cortex, and AP and lateral fluoroscopy confirming plate position and reduction.
Context: A verified image is being sourced for this exposure.
Exposure sequence
- Position the patient supine on a radiolucent table with the ipsilateral scapula boosted and the arm free on an armboard.
- Confirm full AP and lateral fluoroscopy of the entire humerus before draping; test the C-arm from both sides.
- Assess reduction and rotation with the image β for the lateral view, rotate the arm and align the humeral head with the epicondyles to judge rotation.
- Proximal incision: a 4 to 6 cm deltopectoral incision from just below the coracoid distally along the groove (or a short anterolateral deltoid-splitting incision off the acromion for a more lateral proximal plate).
- Distal incision: a 4 to 6 cm anterolateral incision over the distal humerus, centred on the biceps-to-brachioradialis interval.
- Both incisions are deliberately kept remote from the fracture so the fracture biology is never disturbed.
- Deepen the proximal incision through subcutaneous fat to the deltopectoral groove; identify the cephalic vein and protect or ligate it as required.
- Retract deltoid laterally and pectoralis major medially to expose the anterior proximal humerus and the long head of biceps tendon in its groove.
- Elevate a plane directly on bone, deep to deltoid, creating the entry for the proximal end of the plate on the anterolateral proximal humerus; stay on bone and avoid straying distal and posterior where the axillary nerve wraps the surgical neck.
- Deepen the distal incision through subcutaneous tissue and the deep fascia over the biceps-to-brachioradialis interval.
- Gently retract biceps medially; the musculocutaneous nerve and its continuation as the lateral antebrachial cutaneous nerve lie between biceps and brachialis β protect them by staying on the brachialis.
- Incise the brachialis longitudinally in its mid-substance down to bone; retract the medial half with biceps and leave the lateral half attached laterally.
- Elevate the brachialis off the anterior shaft subperiosteally to create the distal end of the tunnel β the lateral brachialis cuff now interposes between the plate and the radial nerve.
- From the distal window, slide a periosteal elevator along the anterior humeral shaft, deep to brachialis and deltoid, strictly on bone, to reach the proximal window β an extrasynovial, epiperiosteal tunnel on the anterior cortex.
- Select a long, pre-contoured anterior humeral plate and bridge the fracture with widely spaced screws (long plate, low screw density).
- Attach the plate to the elevator or a plate-passer and slide it through the tunnel, confirming position on the anterior humerus with fluoroscopy in both planes; verify it sits centrally on the shaft at the fracture and at both ends.
- Restore length, alignment and rotation indirectly using traction, percutaneous pointed reduction clamps and the plate itself as a template; blocking (poller) screws correct residual translation. The fracture haematoma is never opened.
- Hold with one screw proximal and one distal, then place a minimum of three bicortical screws proximal and three distal, spread along the plate (locking screws in the metaphysis, cortical screws in the diaphysis as bone quality dictates).
- Irrigate both windows; no deep closure is needed because brachialis and deltoid fall back over the plate. Close the fascia, subcutaneous tissue and skin in layers and apply a soft dressing with a sling or splint.
The radial nerve runs lateral to the brachialis, between the brachialis and the brachioradialis and extensor carpi radialis longus, in the distal third of the arm. It spirals in the radial groove posteriorly and pierces the lateral intermuscular septum roughly 10 cm proximal to the lateral epicondyle. By splitting the brachialis and keeping every instrument strictly on the anterior cortex, the intact lateral half of brachialis shields the radial nerve from the plate. Straying lateral to the brachialis, or working off bone, puts the radial nerve directly at risk.
Reduction is entirely indirect and fluoroscopic. Confirm true AP and lateral views of the whole humerus, restore length, alignment and rotation with traction and clamps, and use blocking screws for residual translation β the fracture haematoma is left completely undisturbed. This biology-preserving, elastic bridge construct is designed to heal by callus rather than fail by hardware.
Dangers & Extensions
Structures at risk, by layer
| Window | Structure at risk | Protection |
|---|---|---|
| Proximal window | Axillary nerve (anterior branch) | Keep any deltoid split proximal; stay on bone under the deltoid |
| Proximal window | Cephalic vein | Identify in the groove; protect or ligate branches |
| Tunnel and distal window | Radial nerve | Keep the lateral brachialis cuff intact; stay epiperiosteal on the shaft |
| Distal window | Musculocutaneous and lateral antebrachial cutaneous nerves | Retract biceps medially; stay lateral to biceps on the brachialis |
| Distal window | Brachial artery and median nerve | Do not stray medial to biceps |
The most feared structure. It spirals in the radial groove on the posterior shaft, pierces the lateral intermuscular septum roughly 10 cm proximal to the lateral epicondyle, then runs between brachialis and brachioradialis. It is protected by keeping the lateral half of brachialis intact and by sliding the plate strictly on the anterior cortex. Injury causes wrist drop and loss of finger and thumb extension.
The anterior branch wraps the surgical neck of the humerus under the deltoid and is at risk in the proximal window if a deltoid split is extended too far distally. Keep the deltoid split proximal (within roughly 5 cm of the acromion) and stay on bone subdeltoid.
Runs between biceps and brachialis and emerges at the elbow as the lateral antebrachial cutaneous nerve. It is at risk in the distal window if dissection strays medial to biceps β protect by retracting biceps medially and working on the brachialis.
Lies in the deltopectoral groove. Identify it in the proximal window; small branches are coagulated and the main trunk is protected or sacrificed as needed for exposure.
Radial nerve injury management: - Document pre-operative radial nerve function (wrist and finger extension, first web sensation) on every patient.
- If the nerve is identified as injured intra-operatively, visualise it and repair or graft as appropriate.
- A new post-operative palsy: remove constrictive dressings, exclude a compressive cause, document and observe; obtain electromyography at three to four weeks and consider exploration if there is no recovery by the expected timeframe.
- Most traction neurapraxias recover; a persistent complete palsy may require tendon transfers. Extensile modifications. Extend the deltopectoral window proximally for proximal humeral involvement, or use a deltoid-splitting anterolateral acromial approach to reach the proximal humeral head and greater tuberosity (beware the axillary nerve wrapping the surgical neck β stay proximal and on bone). Extend the anterolateral window distally along the Henry approach toward the elbow for distal-third fractures, where the radial nerve can be formally identified and protected as it emerges between brachialis and brachioradialis. Segmental fractures suit MIPO well, as one long plate spans multiple zones without exposure; intra-articular extension requires a separate formal open approach rather than continuing the corridor. Complications
| Complication | Prevention | Management |
|---|---|---|
| Iatrogenic radial nerve palsy | Keep the lateral brachialis cuff intact; slide the plate strictly on bone | Document, observe, EMG; explore if no recovery |
| Malreduction (varus, extension, rotation) | True AP and lateral fluoroscopy; use the plate and blocking screws | Revise fixation if alignment is unacceptable |
| Axillary nerve injury (proximal) | Keep the deltoid split proximal; stay subdeltoid on bone | Observe; most recover |
| Plate malposition (posterior, medial) | Confirm plate-on-bone in both planes before fixation | Reposition and re-fixate |
| Complication | Incidence | Prevention | Treatment |
|---|---|---|---|
| Iatrogenic radial nerve palsy | Low with correct technique | Brachialis protection, stay on bone | Observation, EMG, explore if persistent |
| Nonunion | Low | Biological bridge plating, stable construct | Revision fixation with graft |
| Malunion | Variable | Fluoroscopic reduction checks | Corrective osteotomy if symptomatic |
| Infection | Low (small incisions) | Aseptic technique, antibiotics | Debridement, antibiotics, retain or remove hardware |
| Hardware irritation | Variable | Bury screws, low-profile plate | Hardware removal after union |
Post-operative care and outcomes. Perform a neurovascular check documenting wrist and finger extension against the pre-operative baseline; a sling or splint is used for comfort, with early gentle pendulum and elbow movement as the construct is usually stable. Progress to active-assisted shoulder and elbow range of movement, then strengthening once callus appears, with typical union at three to four months. Follow up at two weeks (wound check and suture removal), six weeks (radiographs, assess callus, advance movement), twelve weeks (radiographs, confirm progression to union, progress loading) and six months (clinical and radiographic review of union). MIPO aims to preserve biology so the construct fails by callus rather than hardware; compared with open plating it reports lower infection and comparable union, and compared with intramedullary nailing it avoids shoulder entry-point problems but demands greater reliance on fluoroscopy and indirect reduction.
Procedures Through This Approach
| Procedure | Suitability | Notes |
|---|---|---|
| Bridge plating of a humeral shaft fracture | Primary indication | Long plate, low screw density, indirect reduction |
| Pathological or impending fracture fixation | Excellent | Long plate spans lesional bone; cement augmentation optional |
| Segmental shaft fracture fixation | Excellent | One construct spans multiple zones |
| Paediatric or adolescent shaft fracture (selected) | Good | Smaller plates; respect the physes |
| Delayed union or nonunion with biologics | Selected | Preserve biology; add graft through the windows |
| Intra-articular fracture reduction | Not suitable | Requires a formal open articular approach |
Viva & Exam Focus
At a glance. The anterior MIPO corridor delivers a long, biology-preserving bridge plate through two small windows β a proximal deltopectoral window (deltoid, axillary nerve, versus pectoralis major, pectoral nerves) and a distal anterolateral window between biceps (musculocutaneous nerve) and brachialis β joined by a submuscular, extrasynovial, epiperiosteal tunnel on the anterior cortex. The patient is positioned supine on a radiolucent table with the whole humerus visible to fluoroscopy. The brachialis is the key protective structure: splitting it in its mid-substance and leaving the lateral half intact interposes muscle between the plate and the radial nerve, which pierces the lateral intermuscular septum roughly 10 cm proximal to the lateral epicondyle. Reduction is indirect β length, alignment and rotation are restored under image intensification with traction, percutaneous clamps, blocking screws and the plate itself as a template, while the fracture haematoma is left undisturbed.
ANTERIORANTERIOR β the corridor in eight steps
DANGERDANGER β structures at risk by layer
BRIDGEBRIDGE β construct principles
Clinical Decision Scenarios
Practise clinical reasoning and management decisions out loud
βA 34-year-old cyclist sustains a comminuted closed mid-shaft humeral fracture with acceptable alignment. You favour surgical fixation with a minimally invasive bridge plate. Describe your approach.β
βOn the morning after MIPO plating of a humeral shaft fracture, the patient cannot extend the wrist or fingers. How do you assess and manage this?β
βHow do you decide the balance between the proximal and distal windows for an anterior MIPO humeral plate, and how can the approach be extended?β
Position
- Supine on a radiolucent table
- Ipsilateral scapula boosted; arm free on an armboard or across the chest
- Confirm full AP and lateral fluoroscopy of the entire humerus before draping
- Pad all pressure points; tourniquet only if it does not obstruct imaging
Two windows
- Proximal: deltopectoral interval (or anterolateral deltoid split)
- Distal: anterolateral between biceps and brachialis
- Both incisions remote from the fracture β biology preserved
- Submuscular extrasynovial tunnel joins them on the anterior cortex
Internervous planes
- Proximal: deltoid (axillary) versus pectoralis major (pectoral nerves)
- Distal superficial: biceps (musculocutaneous) retracted medially
- Distal deep: split the brachialis (dual innervation β safe)
- Lateral half of brachialis left intact to protect the radial nerve
Structures at risk
- Radial nerve β most feared; protected by the lateral brachialis cuff
- Radial nerve pierces the lateral intermuscular septum about 10 cm above the lateral epicondyle
- Axillary nerve at risk proximally with a distal deltoid split
- Musculocutaneous and lateral antebrachial cutaneous nerves at risk medially
- Cephalic vein in the deltopectoral groove
Reduction and fixation
- Indirect reduction: restore length, alignment and rotation
- Traction, percutaneous clamps, blocking screws, plate as template
- Long bridge plate with low screw density (elastic construct)
- At least three bicortical screws proximal and distal, spread along the plate
Closure and pitfalls
- No deep closure β muscle falls back over the plate
- Close fascia, subcutaneous tissue and skin in layers
- Early gentle shoulder and elbow movement once stable
- Watch for radial nerve palsy β document pre- and post-operative function
References
Guidelines, registries and global practice. Humeral shaft fractures are managed worldwide, and operative decision-making converges across examination systems. The majority of closed shaft fractures can be managed non-operatively with functional bracing; operative fixation is reserved for unacceptable alignment, open fractures, polytrauma, bilateral injuries, vascular compromise and pathology. MIPO bridge plating is a recognised biological option alongside intramedullary nailing and open plating. Side-by-side principles (where guidance converges):
| Body | Position on humeral shaft fixation |
|---|---|
| AO Foundation | Biological plating with long plates, low screw density and indirect reduction; respect the soft tissues; bridge comminution rather than compress it |
| BOA / BOAST | Early soft-tissue assessment; definitive fixation once conditions permit; documented neurovascular status including radial nerve function |
| AAOS / OTA | Operative fixation for open fractures, polytrauma, vascular injury, unacceptable alignment and pathological fractures; restore length, alignment and rotation |
Registry and population evidence: - Humeral shaft fractures represent a small fraction of long-bone fractures, with an incidence of roughly 13 to 15 per 100,000 per year and a bimodal distribution (high-energy in young adults, low-energy falls in older patients).
- Functional bracing remains the benchmark non-operative comparator, with high union rates reported in large cohorts; operative series for MIPO and nailing report broadly comparable union with technique-specific complications. Global practice variation. In high-resource settings, pre-contoured locking anterior humeral plates and full intra-operative fluoroscopy are standard. In resource-limited settings, the same biological principles are achieved with standard large-fragment plates contoured intra-operatively, and functional bracing retains a larger role. Consent (globally applicable): discuss iatrogenic radial nerve palsy (the principal neurological risk), infection (low with small incisions), nonunion and malunion, hardware irritation, and the possibility of revision surgery.
Describe the anterior MIPO corridor systematically: supine positioning and fluoroscopy, the proximal deltopectoral and distal anterolateral windows, the brachialis split that protects the radial nerve, the submuscular tunnel, indirect reduction, and the principles of biological bridge plating.
Minimally Invasive Plate Osteosynthesis (MIPO) of the Humeral Shaft Fracture: Is It Possible?
- Cadaveric and preliminary clinical study establishing that a long plate can be delivered to the anterior humeral shaft through proximal and distal windows without exposing the fracture
- Demonstrated that the brachialis can be split to create the distal part of the tunnel while keeping a lateral muscular cuff over the radial nerve
- Showed the feasibility of the two-incision anterior MIPO technique and its biological rationale
- Formed the technical foundation for subsequent clinical MIPO series of humeral shaft fractures
Guidelines for the Clinical Application of the LCP
- Defined the principles of locked plating including bridge plating for comminuted fractures
- Recommended long plates with widely spaced screws to create flexible, biology-preserving constructs
- Emphasised low screw density to distribute strain and avoid stress concentration
- Provided the conceptual basis for the long bridge plate construct used in MIPO
Fractures of the Humerus with Radial-Nerve Paralysis
- Described the distal-third oblique and spiral humeral shaft fracture pattern associated with radial nerve injury
- Showed that the radial nerve is tethered where it pierces the lateral intermuscular septum, making it vulnerable at this level
- Established the anatomical rationale for why the distal third is the danger zone for the radial nerve
- Remains the eponymous reference for understanding radial nerve risk in humeral shaft fractures
Functional Bracing of Fractures of the Shaft of the Humerus
- Landmark report establishing functional bracing as the non-operative standard for closed humeral shaft fractures
- Reported high union rates with bracing across a large cohort of shaft fractures
- Defined acceptable alignment parameters that guide the decision to operate or to continue non-operative care
- Provides the benchmark against which operative methods including MIPO are compared