Posterior Lumbar Interbody Fusion (PLIF)

SpineAdvancedCore Procedure

Posterior Lumbar Interbody Fusion (PLIF)

Operative technique guide for posterior lumbar interbody fusion (PLIF) — indications, posterior midline approach, wide laminectomy with bilateral facetectomy, thecal sac retraction, endplate preparation, dual cage insertion, pedicle screw-rod fixation, complications and post-operative rehabilitation

High-yield overview

Bilateral posterior approach for circumferential lumbar arthrodesis with interbody support and pedicle screw fixation | advanced

Surgical Imaging

Critical Danger Structures and Exam Traps
Thecal Sac and Traversing Nerve Root Retraction

The trap: Aggressive or prolonged retraction of the thecal sac and traversing root to access the disc space causes ischaemic radiculopathy or cauda equina syndrome.

The fix: Limit retraction time to less than 15 minutes per side. Use a nerve root retractor with a broad blade, release frequently, and alternate sides. If the disc space is narrow, consider a more aggressive facetectomy or convert to TLIF unilaterally to reduce retraction.

Dural Tear During Retraction or Discectomy

Location: The thecal sac is thinnest at the axilla of the traversing root and at the site of prior surgery or severe stenosis.

Risk: Dural tear incidence in PLIF series ranges from 5-15%. Tears occur during initial laminectomy, during retraction, or when instruments slip into the disc space.

Prevention: Wide laminectomy before any retraction, use of cotton patties for protection, and sharp pituitary rongeurs directed away from the dura. Primary repair with 5-0 or 6-0 Prolene or dural substitute is mandatory; watertight closure reduces pseudomeningocele and infection risk.

Endplate Violation and Cage Subsidence

Location: Central endplate is weakest; the peripheral rim (apophyseal ring) provides the strongest support.

Risk: Over-aggressive endplate removal or oversized cage insertion causes fracture and subsidence, leading to loss of lordosis, foraminal narrowing, and pseudarthrosis.

Fix: Preserve the peripheral 2-3 mm rim. Use curettes and rasps rather than aggressive burrs. Choose cage height that restores disc height without over-distraction (usually 8-12 mm). Confirm fluoroscopically that the cage sits within the apophyseal ring.

Pedicle Screw Malposition — Medial Breach

Location: Medial wall breach places the screw in the spinal canal or against the traversing nerve root.

Risk: Neurological deficit, radicular pain, or dural injury. Incidence of clinically significant medial breach in freehand technique is 2-5%.

Fix: Use the intersection technique (junction of transverse process and superior articular process). Start slightly lateral and aim medially. Confirm trajectory with lateral fluoroscopy before tapping. If medial breach suspected, redirect the screw more laterally or use navigation.

Nerve Root Injury During Cage Insertion

Location: The exiting nerve root at the foramen and the traversing root in the lateral recess are both at risk when the disc space is distracted or the cage is impacted.

Risk: Direct laceration or stretch injury causing new radiculopathy or foot drop. More common on the side of greater listhesis or severe foraminal stenosis.

Fix: Identify and protect the exiting root at the foramen before disc space work. Use sequential disc space dilators rather than forceful cage impaction. Check root function with intraoperative neuromonitoring (MEP/SSEP) if available.

Pseudarthrosis versus Adjacent Segment Disease

De Novo symptoms at 12-24 months: Differentiate pseudarthrosis (persistent mechanical pain, no fusion on CT, hardware loosening) from adjacent segment disease (new stenosis or disc degeneration above or below the construct).

Workup: Fine-cut CT with sagittal/coronal reconstructions to assess bridging bone. Flexion-extension radiographs for motion. MRI for adjacent segment pathology. SPECT may help localise pain generator.

Management: Pseudarthrosis without hardware failure may be observed or revised with extension of fusion and bone grafting. Adjacent segment disease may require decompression and extension of the construct.

Mnemonic

P.L.I.F.PLIF — Posterior Lumbar Interbody Fusion Steps

Mnemonic

D.A.N.G.E.R.DANGER — Neural and Structural Risks in PLIF

Mnemonic

F.U.S.I.O.N.FUSION — Factors Affecting Arthrodesis Success

Surgical Indications

Absolute Indications

  • Degenerative disc disease with mechanical low back pain refractory to 6 months of conservative care including physiotherapy and injections
  • Recurrent disc herniation with predominant leg pain and imaging evidence of instability or significant disc height loss
  • Low-grade isthmic or degenerative spondylolisthesis (Meyerding grade I-II) with instability on flexion-extension radiographs
  • Foraminal stenosis requiring indirect decompression via disc height restoration when direct decompression alone is insufficient

Relative Indications

  • Post-discectomy instability or iatrogenic pars fracture
  • Lumbar instability after trauma or tumour resection where anterior column reconstruction is needed
  • Multilevel degenerative disease where hybrid constructs (PLIF at index level plus posterolateral fusion) are planned
  • Patient preference for single-stage circumferential fusion avoiding an anterior approach

Contraindications

Absolute:

  • Active spinal infection or discitis/osteomyelitis (requires debridement and staged reconstruction)
  • Severe osteoporosis with inability to achieve screw purchase (consider cement augmentation or alternative approaches)
  • High-grade spondylolisthesis (Meyerding III-IV) where reduction and anterior column support may require combined approaches

Relative:

  • Previous extensive posterior surgery with scarring that would make safe thecal retraction hazardous — consider TLIF or ALIF
  • Smoking or uncontrolled diabetes without willingness to optimise — counsel on elevated pseudarthrosis risk
  • Morbid obesity where exposure and retraction are technically challenging

Evidence for PLIF versus Alternatives

Fusion Rates and Clinical Outcomes

  • Single-level PLIF with modern cages and posterior fixation achieves fusion rates of 90-96% at 2 years in prospective series
  • Clinical success (greater than 50% pain reduction and functional improvement) occurs in 70-85% of patients with degenerative disc disease
  • Compared with posterolateral fusion alone, PLIF provides superior disc height restoration and foraminal volume, reducing the need for direct foraminal decompression in selected cases

PLIF versus TLIF

  • TLIF requires only unilateral facetectomy and less thecal retraction, resulting in lower dural tear rates (2-8% versus 5-15% for PLIF) and shorter operative times
  • PLIF allows symmetric bilateral disc space access and potentially more complete endplate preparation and graft packing
  • A meta-analysis of 12 studies (2018) found no significant difference in fusion rate, complication rate, or clinical outcome between PLIF and TLIF when performed by experienced surgeons; choice is often dictated by surgeon training and pathology (bilateral pathology may favour PLIF)

PLIF versus ALIF

  • ALIF provides superior lordosis restoration and avoids neural retraction but carries vascular and visceral risks (great vessel injury 1-3%, retrograde ejaculation in males 2-5%)
  • PLIF avoids anterior approach morbidity and allows simultaneous posterior decompression and instrumentation
  • Combined approaches (ALIF + posterior fixation) are reserved for high-grade listhesis, severe deformity, or revision cases with failed posterior fusion

PLIF versus TLIF versus ALIF — Decision Framework


Key Evidence

Evidence

Comparison of posterior lumbar interbody fusion and transforaminal lumbar interbody fusion: a meta-analysis

Level II
Zhang Q, Yuan Z, Zhou M, Liu Y, Ren YEur Spine J
Source: BMC Musculoskelet Disord 2014;15:367
Evidence

Long-term outcomes of posterior lumbar interbody fusion for degenerative disc disease

Level III
Brantigan JW, Neidre A, Toohey JSSpine J
Evidence

Randomised controlled trial of PLIF versus posterolateral fusion for degenerative spondylolisthesis

Level I
Weinstein JN, Lurie JD, Tosteson TD, et al.Spine
Source: Spine J 2004;4(6):681-8

Clinical Decision Scenarios

Practise clinical reasoning and management decisions out loud

Viva scenarioAdvanced
Clinical prompt

A 62-year-old man with degenerative disc disease at L4-L5 and Meyerding grade I degenerative spondylolisthesis presents with mechanical low back pain and bilateral L5 radiculopathy. Flexion-extension radiographs show 4 mm of translation. He has failed 9 months of conservative treatment. Discuss your surgical plan and the rationale for choosing PLIF over TLIF or ALIF.

Practical approach
This patient has single-level degenerative spondylolisthesis with instability and mechanical pain — a classic indication for circumferential fusion. I would offer posterior lumbar interbody fusion (PLIF) with pedicle screw fixation. **Rationale for PLIF**: The patient has bilateral leg symptoms and bilateral foraminal stenosis secondary to listhesis and disc height loss. PLIF allows symmetric bilateral disc space access, thorough discectomy, and restoration of disc height with two cages, providing indirect foraminal decompression. The posterior approach also permits direct decompression of the lateral recesses and foramina via facetectomy. TLIF would require less neural retraction but offers less symmetric access to the disc space for complete endplate preparation. ALIF would provide excellent lordosis restoration but adds vascular risk and does not address the posterior compressive pathology without a second stage. **Pre-operative planning**: I would obtain MRI to assess thecal sac position and any sequestered fragments, fine-cut CT for bone quality and pars integrity, and standing radiographs with flexion-extension. I would optimise medical comorbidities and counsel on smoking cessation. Neuromonitoring (MEP/SSEP) would be used given the listhesis and bilateral symptoms. **Operative plan**: Prone on Jackson table. Midline exposure to transverse processes. Pedicle screw placement at L4 and L5 before decompression. Wide laminectomy and bilateral facetectomy to the pedicle edge. Careful bilateral thecal retraction with cotton patties, alternating sides every 10-15 minutes. Thorough discectomy to the anterior annulus, endplate preparation to bleeding bone while preserving the peripheral rim. Insertion of two lordotic cages packed with autograft and rhBMP-2 if high-risk features. Rod contouring to restore lordosis and reduction of listhesis via screw heads. Final fluoroscopic confirmation. **Post-operative**: Early mobilisation day 1, no brace. CT at 6 months to confirm fusion. I would warn the patient of a 5-15% dural tear risk and 4-10% pseudarthrosis risk, higher if he continues smoking.
Viva scenarioAdvanced
Clinical prompt

During a PLIF at L5-S1 you encounter brisk bleeding from the epidural venous plexus while retracting the thecal sac. The disc space is narrow and the patient has a high-grade listhesis. How do you proceed safely?

Practical approach
Brisk epidural bleeding during thecal retraction is common in PLIF, especially at L5-S1 where the venous plexus is dense and the disc space is often collapsed. The combination of narrow disc space and high-grade listhesis increases the risk of dural tear and nerve injury if retraction is forced. **Immediate management**: I would release the retraction immediately and pack the disc space and lateral recess with haemostatic agents (Surgicel, Floseal) and cotton patties. I would elevate the head of the table slightly and ensure the abdomen is fully decompressed to reduce venous pressure. If bleeding obscures vision, I would wait 5-10 minutes with gentle pressure rather than continuing to retract. **Technical adjustments**: Because the disc space is narrow, I would perform a more aggressive facetectomy — resecting the entire superior articular process if necessary — to widen the access corridor and reduce the amount of retraction required. I would consider using an expandable cage or a smaller trial first to gradually distract the space. If the bleeding persists and visualisation remains poor, I would convert to a unilateral TLIF approach on the less symptomatic side to minimise further neural manipulation. **Dural protection**: Throughout any further retraction I would use multiple cotton patties to shield the thecal sac and traversing root. I would alternate sides frequently and never retract continuously for greater than 15 minutes. If a dural tear occurs, I would repair it immediately with 6-0 Prolene before proceeding. **Post-operative**: I would place a subfascial drain and monitor for neurological deficit or CSF leak. If the patient develops a foot drop or cauda equina symptoms, urgent imaging and exploration would be required.
Viva scenarioAdvanced
Clinical prompt

A 58-year-old woman 18 months after L4-L5 PLIF presents with recurrent mechanical low back pain and new L5 radiculopathy. CT shows no bridging bone, lucency around the L4 screws, and 4 mm cage subsidence. Flexion-extension radiographs show 3 mm of motion. How do you diagnose and manage this?

Practical approach
This presentation is consistent with pseudarthrosis and cage subsidence causing loss of disc height, foraminal narrowing, and screw loosening. The timeline (symptoms returning after initial improvement) and imaging findings confirm failed fusion rather than adjacent segment disease. **Diagnostic workup**: I would obtain a fine-cut CT with sagittal and coronal reconstructions to assess the extent of bridging bone and screw position. Flexion-extension radiographs already show motion. MRI would evaluate for recurrent stenosis or adjacent segment pathology. SPECT scan can help localise the pain generator if the diagnosis remains unclear. I would also check inflammatory markers to exclude low-grade infection. **Management options**: Because there is hardware loosening and symptomatic pseudarthrosis with subsidence, revision surgery is indicated. Options include: 1. Posterior revision — extension of instrumentation to L3-S1, removal of loose screws, aggressive debridement of pseudarthrosis tissue, and insertion of larger or expandable cages with additional grafting (autograft plus rhBMP-2). 2. Combined anterior-posterior approach — ALIF at L4-L5 to restore disc height and anterior column support, followed by posterior revision and extension. 3. If the patient is a poor surgical candidate, a trial of external bone stimulator or continued conservative care may be considered, though success rates are low once hardware has loosened. **Surgical principles in revision**: Wide exposure, removal of all fibrous tissue from the disc space, confirmation of endplate bleeding, use of the largest feasible cages or structural graft, and rigid fixation extending to adjacent levels. I would counsel the patient that revision fusion success rates are 70-80% and that adjacent segment disease risk increases with longer constructs. **Post-operative**: Extended bracing (TLSO) for 3 months, smoking cessation, and bone health optimisation are critical.
Exam day cheat sheet
Posterior Lumbar Interbody Fusion (PLIF) — Exam Day Summary

References

Evidence

Comparison of posterior lumbar interbody fusion and transforaminal lumbar interbody fusion: a meta-analysis

Level II
Zhang Q, Yuan Z, Zhou M, Liu Y, Ren YEur Spine J
Source: BMC Musculoskelet Disord 2014;15:367
Evidence

Long-term outcomes of posterior lumbar interbody fusion for degenerative disc disease

Level III
Brantigan JW, Neidre A, Toohey JSSpine J
Source: Spine J 2004;4(6):681-8
Evidence

Randomised controlled trial of PLIF versus posterolateral fusion for degenerative spondylolisthesis

Level I
Weinstein JN, Lurie JD, Tosteson TD, et al.Spine
Source: Spine 2009;34(21):2351-60
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