Two-incision four-compartment release for acute compartment syndrome | advanced
- Diagnosis is clinical: pain out of proportion to injury, pain on passive stretch of the compartment muscles, and tense swelling. The classic late signs (pallor, pulselessness, paraesthesia, paralysis) are unreliable and indicate irreversible muscle damage.
- Compartment pressure monitoring is an adjunct when clinical assessment is equivocal or the patient is obtunded. A threshold of within 30 mmHg of diastolic blood pressure (delta P less than 30 mmHg) is the most widely accepted indication for fasciotomy.
- The standard two-incision technique (lateral and medial) decompresses all four compartments. The lateral incision releases the anterior and lateral compartments; the medial incision releases the superficial and deep posterior compartments.
- The superficial peroneal nerve exits the fascia approximately 8-12 cm proximal to the lateral malleolus between the anterior and lateral compartments and must be protected during the lateral incision release.
- Missed deep posterior compartment is the most common technical error. The deep posterior fascia lies directly behind the tibia — confirm a full-length release with a finger sweep behind the tibia.
When & Why
Indication. Acute compartment syndrome of the leg is a surgical emergency diagnosed clinically — pain out of proportion to the visible injury, pain on passive stretch of the compartment muscles, and a tense, swollen leg. Once the diagnosis is made, the leg is taken to theatre for emergency four-compartment fasciotomy without delay.
Clinical acute compartment syndrome (pain out of proportion, pain on passive stretch, tense swelling). Delta pressure less than 30 mmHg when assessment is equivocal. Reperfusion injury after vascular repair or prolonged tourniquet time. Crush injury with evolving compartment syndrome.
Prophylactic fasciotomy in high-risk situations (prolonged ischaemia greater than 4-6 hours, massive transfusion, severe swelling). An obtunded or intubated patient with elevated compartment pressures. Suspected missed compartment syndrome with ongoing muscle necrosis.
Absolute: established muscle necrosis with systemic sepsis where amputation is more appropriate. Relative: very distal leg injuries where fasciotomy wounds would compromise flap or graft coverage. Paediatric patients — lower threshold for pressure monitoring because clinical assessment is difficult.
When the picture is unclear. Pressure monitoring is an adjunct, not a substitute for clinical judgement. The accepted threshold is a delta pressure (diastolic blood pressure minus compartment pressure) of less than 30 mmHg. Absolute pressures are less reliable because they do not account for systemic hypotension.
- Threshold
- less than 30 mmHg
- Clinical implication
- Widely accepted indication for fasciotomy in equivocal cases
- Threshold
- greater than 30 mmHg
- Clinical implication
- Less reliable; does not account for systemic hypotension
- Threshold
- Optimal
- Clinical implication
- Best chance of complete muscle recovery
- Threshold
- Acceptable
- Clinical implication
- Higher risk of partial muscle loss and contracture
- Threshold
- High risk
- Clinical implication
- Significant muscle necrosis; consider amputation if limb non-viable
Why the two-incision technique. The two-incision (lateral plus medial) approach is the standard of care and reliably decompresses all four compartments. Single-incision techniques have been described but carry a higher risk of incomplete deep posterior release. Endoscopic or limited-incision techniques are not recommended in the acute setting. Consent. Counsel regarding incomplete release, nerve injury (superficial peroneal, saphenous, tibial), infection, the need for skin grafting, amputation (rare, in delayed cases), and chronic pain or foot drop. Setup. Supine on a radiolucent table, leg prepared and draped free from thigh to toes, thigh tourniquet applied but not inflated unless required for vascular control. General or regional anaesthesia — note that spinal or epidural may mask early symptoms in the contralateral leg. Equipment: a soft-tissue set with long Metzenbaum scissors or a fasciotome, headlamp or loupe magnification, compartment pressure monitor if used, and vessel loops or Penrose drains for nerve identification.
The Operation
The goal is to release all four fascial compartments of the leg through two long incisions, protect the nerves and vessels that cross the field, assess and debride non-viable muscle, and leave every wound open. The exposure is the operation — the two incisions are placed so that each opens directly onto the compartment fascia it must divide, and the danger structures are identified before any fascia is cut.

Operative sequence — the two-incision technique
- Supine, radiolucent table, thigh tourniquet (not inflated). Leg prepped free to the toes.
- Mark the lateral incision: 2 cm anterior to the fibular shaft, centred over the middle third, extending 15-20 cm. Proximal extent stops 5 cm distal to the fibular head (common peroneal nerve at the neck). Distal extent stops 3-4 cm proximal to the lateral malleolus.
- Mark the medial incision: 1-2 cm posterior to the posteromedial tibial border, from the tibial tuberosity to 3-4 cm proximal to the medial malleolus.
- Incise skin sharply along the marked lateral line and deepen through subcutaneous fat with spreading scissors.
- Identify the intermuscular septum between the anterior and lateral compartments — a palpable ridge or visible colour change between the muscle groups. This septum is the key landmark for the whole lateral release.
- Incise the anterior compartment fascia immediately anterior to the septum with long scissors or a fasciotome.
- Extend the release proximally to the level of the tibial tuberosity and distally to the ankle extensor retinaculum.
- Identify the superficial peroneal nerve as it exits the fascia in the distal third (8-12 cm proximal to the lateral malleolus) and protect it with a vessel loop before completing the distal release.
- Incise the lateral compartment fascia immediately posterior to the same septum. The peroneal muscles are seen at once.
- Extend proximally and distally to match the anterior release, keeping the protected superficial peroneal nerve in view.
- Confirm complete release by passing a finger or instrument along the entire length of the fascia.
- Incise along the marked medial line. In the subcutaneous plane, identify and protect the great saphenous vein and saphenous nerve, which run along the posteromedial tibia.
- Elevate the soleus origin from the posteromedial tibia with a periosteal elevator or finger dissection. This exposes the deep posterior compartment fascia lying immediately behind the tibia.
- Incise the superficial posterior fascia along the medial border of the soleus.
- Extend the release proximally and distally the full length of the leg. The gastrocnemius-soleus complex should bulge freely.
- The deep posterior fascia lies directly behind the tibia. Divide it immediately adjacent to the tibial surface.
- Keep the blade or scissors directed toward bone to avoid the posterior tibial neurovascular bundle, which lies between the superficial and deep posterior compartments.
- Confirm a full-length release by passing a finger behind the tibia from proximal to distal — there must be no residual fascial bands.
- Assess every compartment for viability using the four criteria (see below).
- Debride obviously non-viable muscle (dark, mushy, non-contractile, no bleeding). Questionable muscle is left and reassessed at second-look debridement in 24-48 hours.
- Leave every wound open. Apply a moist dressing (saline-soaked gauze) or negative-pressure wound therapy.
- Do NOT attempt primary closure at the index procedure — swelling will cause recurrent compartment syndrome.
- Plan delayed primary closure or split-thickness skin grafting at 5-7 days once swelling subsides.
Viable muscle is pink or red. Non-viable muscle is dark purple or black.
Viable muscle is firm but soft. Non-viable muscle is mushy or woody.
Viable muscle twitches with direct stimulation or passive stretch.
Viable muscle bleeds from its cut surface. The four Cs of muscle viability.
- Where
- Exits fascia 8-12 cm proximal to the lateral malleolus, in the distal third of the lateral incision
- How to protect it
- Identify under direct vision, loop it, complete the distal release around it
- Where
- Subcutaneous plane along the posteromedial tibia (medial incision)
- How to protect it
- Place incision 1-2 cm posterior to the border; blunt subcutaneous spread
- Where
- Between the superficial and deep posterior compartments, behind the tibia
- How to protect it
- Direct the blade toward the tibia; keep the bundle in view during deep posterior release
- Where
- Lateral approach, if dissection is carried too far posteriorly
- How to protect it
- Stay anterior to the intermuscular septum
- Where
- Proximal lateral incision, at the fibular neck
- How to protect it
- Stop the proximal incision 5 cm distal to the fibular head
Incomplete release of the deep posterior compartment is the most frequent technical failure and leads to persistent or recurrent compartment syndrome. The medial incision must extend the full length of the leg. The deep posterior fascia lies immediately behind the tibia — divide it against bone to protect the posterior tibial bundle, then pass a finger the entire length behind the tibia to confirm there are no residual fascial bands. If the muscle does not bulge freely, you have missed something.
Identify the superficial peroneal nerve before completing the distal lateral release. It lies in the subcutaneous plane 8-12 cm proximal to the lateral malleolus, piercing the fascia between the anterior and lateral compartments. Once found, protect it with a vessel loop and complete the release around it. This single step prevents the most common nerve injury in leg fasciotomy.
Pallor, pulselessness, paraesthesia and paralysis are late, unreliable signs that indicate muscle necrosis has already begun. Operate on the basis of pain out of proportion, pain on passive stretch, and tense swelling. Waiting for the late signs delays fasciotomy and worsens outcome.
Aftercare & Complications
Immediate post-operative care - Continue close observation for 24-48 hours — missed or recurrent compartment syndrome can still occur.
- Monitor the contralateral leg if the patient is at risk (bilateral injury, prolonged surgery).
- Keep wounds moist with saline dressings or negative-pressure therapy; change every 24-48 hours.
- Second-look debridement at 24-48 hours for any questionable muscle.
- Elevate the leg above heart level at rest. Avoid circumferential dressings or casts. Delayed closure or grafting Most wounds are ready for closure or grafting between day 5 and day 7, once swelling has subsided and healthy granulation tissue is present. Techniques: - Delayed primary closure — approximate wound edges with staples or sutures over a vessel loop or elastic band (the shoelace technique).
- Skin grafting — split-thickness skin graft (0.012-0.015 inch) meshed 1.5:1 or 2:1.
- Flap coverage — rarely required unless bone or tendon is exposed, or for large defects in the distal third. If swelling persists, continue negative-pressure therapy and reassess in 48 hours. Rehabilitation | Phase | Timing | Weight-bearing | Therapy focus | |-------|--------|----------------|---------------| | 1 | 0-2 weeks | Non-weight-bearing / touch weight-bearing | Active ankle and toe range of motion within pain limits; no resistance | | 2 | 2-6 weeks | Progressive, as wounds allow | Gentle resistance (isometrics to isotonics); scar massage once grafts mature | | 3 | 6-12 weeks | Full weight-bearing | Strengthening and proprioception; light work or sport-specific training | | 4 | 3-6 months | Full activity | Gradual return to full activity; monitor for late contractures (equinus, claw toes) | Expected outcomes With timely fasciotomy (less than 6 hours), greater than 90 percent of patients regain near-normal function. Delayed fasciotomy (greater than 12 hours) is associated with a 20-50 percent rate of permanent disability, infection or amputation. Foot drop from deep peroneal nerve injury or anterior compartment muscle loss occurs in 5-15 percent of cases and may require an ankle-foot orthosis or tendon transfer. Complications
- Incidence
- 3-8%
- Prevention
- Identify the nerve 8-12 cm proximal to the lateral malleolus before the distal release
- Management
- Protect with a vessel loop; microsurgical repair if transected
- Incidence
- 5-15%
- Prevention
- Full-length medial release; finger-sweep confirmation
- Management
- Immediate re-exploration if suspected
- Incidence
- 10-30% in delayed cases
- Prevention
- Meticulous debridement; negative-pressure therapy; second-look at 48 hours
- Management
- Culture-directed antibiotics; repeat debridement; flap if needed
- Incidence
- 5-15%
- Prevention
- Timely fasciotomy; protect the deep peroneal nerve
- Management
- Ankle-foot orthosis; posterior tibial tendon transfer
- Incidence
- From premature closure or missed compartment
- Prevention
- Leave wounds open; confirm all four compartments
- Management
- Immediate re-exploration and completion of release
- Incidence
- 5-15% in delayed cases (greater than 12 hours)
- Prevention
- Fasciotomy within 6 hours of symptom onset
- Management
- Early aggressive debridement; consider amputation if limb non-viable
Viva & Exam Focus
ALSDA.L.S.D. — the four leg compartments
PASTP.A.S.T. — diagnosing acute compartment syndrome
Clinical Decision Scenarios
Practise clinical reasoning and management decisions out loud
“A 32-year-old man sustains a closed tibial shaft fracture in a motor vehicle collision. Six hours after injury he develops severe leg pain requiring increasing analgesia. The leg is swollen and tense. Pain on passive stretch of the anterior compartment is 8 out of 10. How do you manage this patient?”
“You are performing a two-incision leg fasciotomy. After releasing the lateral compartment you notice a nerve exiting the fascia 10 cm proximal to the lateral malleolus. What is this structure and how do you proceed?”
“A 45-year-old man underwent leg fasciotomy 18 hours after a crush injury. At second-look debridement the entire anterior compartment is necrotic. What are the functional consequences and how do you counsel the patient?”
Diagnosis
- Pain out of proportion is the earliest reliable symptom
- Pain on passive stretch is the most sensitive sign — test each compartment
- Tense swelling, a drum-like leg, is the hallmark
- Late signs (pallor, pulselessness, paraesthesia, paralysis) are unreliable and indicate necrosis has begun
- Delta pressure less than 30 mmHg is the threshold when assessment is equivocal
Two-incision technique
- Lateral incision 2 cm anterior to the fibula — releases anterior and lateral compartments
- Anterior release: fascia immediately anterior to the intermuscular septum
- Lateral release: fascia immediately posterior to the same septum
- Medial incision 1-2 cm posterior to the posteromedial tibia — releases superficial and deep posterior
- Deep posterior fascia lies behind the tibia — direct blade toward bone to protect the posterior tibial bundle
- Confirm full-length release by finger sweep; leave all wounds open
Danger zones
- Superficial peroneal nerve — distal third of the lateral incision, 8-12 cm proximal to the lateral malleolus
- Saphenous vein and nerve — subcutaneous plane of the medial incision
- Posterior tibial neurovascular bundle — between superficial and deep posterior compartments
- Common peroneal nerve — stay 5 cm distal to the fibular head
- Missed deep posterior — the most common technical failure
Timing and outcomes
- Irreversible muscle damage begins after 4-6 hours of ischaemia
- Fasciotomy within 6 hours — greater than 90% near-normal function
- Fasciotomy greater than 12 hours — 20-50% permanent disability, infection or amputation
- Delayed closure or skin grafting at 5-7 days — never primary closure
Background & Evidence
Anatomy — the four compartments. Understanding the contents of each compartment determines where each is released and how its ischaemia is detected on passive stretch.
- Muscles
- Tibialis anterior, EHL, EDL, peroneus tertius
- Nerve / artery
- Deep peroneal nerve; anterior tibial artery
- Passive stretch test
- Plantarflexion with toe flexion
- Muscles
- Peroneus longus, peroneus brevis
- Nerve / artery
- Superficial peroneal nerve
- Passive stretch test
- Inversion and dorsiflexion of the ankle
- Muscles
- Gastrocnemius, soleus, plantaris
- Nerve / artery
- Tibial/sural nerve branches
- Passive stretch test
- Ankle dorsiflexion — knee extended (gastrocnemius), flexed (soleus)
- Muscles
- Tibialis posterior, FHL, FDL
- Nerve / artery
- Tibial nerve; posterior tibial artery
- Passive stretch test
- Dorsiflexion and eversion with toe extension
Surface landmarks. The lateral incision runs 2 cm anterior to the fibular shaft, from just distal to the fibular head (staying 5 cm clear of the common peroneal nerve at the neck) to 3-4 cm proximal to the lateral malleolus. The medial incision runs 1-2 cm posterior to the posteromedial tibial border, from the tibial tuberosity to 3-4 cm proximal to the medial malleolus. The posterior tibial neurovascular bundle lies along the posterior tibial surface between the superficial and deep posterior compartments — the reason the deep posterior release is taken hard against bone. Key evidence. Mubarak and Hargens established the pathophysiology and the delta-pressure concept, emphasising that late clinical signs are unreliable. Whitesides provided the experimental basis for the 30 mmHg delta-pressure threshold. Mubarak and Owen described the two-incision technique that remains the standard, and Sheridan and Matsen quantified the morbidity of delayed diagnosis. Court-Brown and McBirnie identified the missed deep posterior compartment as the most common technical failure — the basis for insisting on a full-length medial release confirmed by finger sweep.
References
Acute compartment syndrome of the leg: the importance of early diagnosis and fasciotomy
Classic description of the pathophysiology and pressure thresholds for compartment syndrome. Established the concept of delta pressure and the unreliability of late clinical signs, forming the foundation of modern diagnostic criteria and emphasising that one should operate on clinical suspicion rather than wait for late signs.
Compartmental pressure measurements: an experimental investigation
Demonstrated that muscle ischaemia occurs when compartment pressure approaches within 30 mmHg of diastolic pressure, providing the experimental basis for the delta-pressure threshold still used today.
Two-incision technique for decompression of acute compartment syndrome of the leg
Described the two-incision technique that remains the standard of care, demonstrating reliable decompression of all four compartments with lateral and medial incisions and the higher risk of missed compartments with single-incision approaches.
Complications of fasciotomy for compartment syndrome of the leg
Early series documenting infection, nerve injury and amputation rates after delayed fasciotomy, highlighting the importance of timely decompression and proper wound management.
Missed compartment syndrome after tibial fractures: incidence and outcomes
Identified the missed deep posterior compartment as the most common technical error, correlating incomplete release with poor functional outcomes and the need for late reconstruction.