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Evidence. Clarity. Practice.

© 2026 OrthoVellum. For educational purposes only.

Not medical advice. Verify clinically important information against current local guidance.

Back to Research
Level VMust KnowHand & Upper LimbExpert Opinion

Evidence brief

Nerve Repair Evidence

Peripheral Nerve Repair Principles

Authors
Mackinnon SE, Dellon AL
Journal
Surgery of the Peripheral Nerve
Year
1988

Key Findings

  • 1

    Tension-free repair essential

  • 2

    Primary repair preferred when possible

  • 3

    Nerve regeneration ~1mm/day

  • 4

    Proximal injuries have better outcomes

  • 5

    Nerve grafting for gaps >3-4cm

Clinical Implications

Fundamental principles of nerve repair guide management of traumatic nerve injuries. Tension-free coaptation with proper alignment is critical for optimal regeneration.

Teaching Note

Classic teaching: repair without tension, epineural vs grouped fascicular repair, timing (primary if possible, delayed if contaminated). Know Sunderland classification. Regeneration rate 1mm/day. Calculate expected recovery time. Discuss conduits and grafts for gaps.

Citation

Mackinnon SE, Dellon AL. Surgery of the Peripheral Nerve. New York: Thieme; 1988.

Evidence Level

V

Level V

Expert opinion or mechanism-based reasoning

Topics

nerve repairmicrosurgeryregenerationprinciples

Related Topics

  • Peripheral Nerve Injury
  • Nerve Grafting
  • Brachial Plexus

External Links

Related Papers

V

Tendon Transfer Principles

Brand PW (1985)

IV

Replantation Indications

Tamai S (1993)

I

Carpal Tunnel Release Evidence

Shi Q (2011)

III

Zone II Flexor Tendon Repair

Strickland JW (1980)