Skip to main content
OrthoVellumOrthopaedic Exam Prep
Pricing
About OrthoVellum
OrthoVellum
A living orthopaedic atlas

Exam-focused orthopaedic references, a question bank, viva practice, and spaced-repetition revision — with every clinical claim traceable to its source. Content is educational only and is not a substitute for local supervision, clinical judgement, or institutional policy.


Library

  • Clinical Topics
  • Blog
  • Site Updates
  • Content Methodology

Company

  • About Us
  • Authors & Disclosure
  • Editorial Team
  • Editorial Policy
  • Advertising Policy

Legal

  • Terms of Service
  • Privacy Policy
  • Cookie Policy
  • Medical Disclaimer
  • Copyright & DMCA

Support

  • Support OrthoVellum
  • Help Center
  • Contact
  • Accessibility
Evidence. Clarity. Practice.

© 2026 OrthoVellum. For educational purposes only.

Not medical advice. Verify clinically important information against current local guidance.

Back to Research
Level IMust KnowTraumaRandomised Controlled Trial

Evidence brief

SPRINT:SPRINT Trial

Reamed Intramedullary Nailing versus Unreamed Intramedullary Nailing for Open and Closed Tibial Fractures

Authors
Study to Prospectively Evaluate Reamed Intramedullary Nails in Patients with Tibial Fractures Investigators
Journal
J Bone Joint Surg Am
Year
2008
Sample
n=1,319
Follow-up
12 months

Key Findings

  • 1

    Reamed nailing reduced reoperation risk in closed tibial fractures (RR 0.67)

  • 2

    No significant difference in open tibial fractures

  • 3

    Primary outcome: reoperation within 12 months

  • 4

    1,319 patients randomized across 29 centers

  • 5

    Subgroup analysis showed reaming benefit mainly in closed fractures

Clinical Implications

The SPRINT trial established that reamed intramedullary nailing is superior to unreamed nailing for closed tibial shaft fractures, reducing the need for reoperation. For open fractures, the difference was not significant, supporting either approach.

Teaching Note

Key viva question: 'Do you ream for tibial shaft fractures?' Answer: Yes for closed fractures (SPRINT trial showed reduced reoperations). For open fractures, both acceptable. Know the relative risk reduction (33% fewer reoperations with reaming in closed fractures).

Citation

SPRINT Investigators. Reamed versus unreamed intramedullary nailing of the tibia. J Bone Joint Surg Am. 2008;90(12):2567-2578.

PubMedDOI

Evidence Level

I

Level I

Systematic review of RCTs or high-quality RCT

Topics

tibial fractureintramedullary nailingreamedunreamedRCT

Related Topics

  • Tibial Shaft Fractures
  • Intramedullary Nailing
  • Open Fractures

External Links

View on PubMedView via DOI

Related Papers

I

FLOW Trial

FLOW Investigators (2015)

I

FAITH Trial

FAITH Investigators (2017)

I

HEALTH Trial

HEALTH Investigators (2019)

I

INSITE Trial

Metsemakers WJ (2022)