Excision Arthroplasty | Salvage Procedure | Definitive or Staging
- Primary indication: Periprosthetic joint infection (PJI) not suitable for DAIR
- Named after Gathorne Robert Girdlestone (1881-1950)
- Results in significant LLD (4-6cm) and functional limitation
- Can be definitive or interim (2-stage revision)
- Harris hip score improves with reimplantation
- “Trendelenburg gait expected post-procedure
- “Hip abductors critical for stability of pseudarthrosis
- “Spacer preferred for interim if reimplantation planned
- “Higher success rate when combined with adequate antibiotics
Periprosthetic joint infection where DAIR has failed or is contraindicated. Patient must be medically fit for surgery and able to tolerate prolonged antibiotics. Can be definitive (permanent) or interim (before reimplantation).
Significant disability expected: 4-6cm limb length discrepancy, Trendelenburg gait, need for walking aids. Pain relief usually achieved. 50-60% ambulatory with aids. Better than ongoing sepsis or repeated failed surgery.
Complete removal of infected prosthesis, cement, and devitalized tissue. Aggressive debridement is key to infection eradication. Preserve abductor mechanism when possible for pseudarthrosis stability.
Antibiotic-loaded articulating spacer preferred for staging if reimplantation planned. Spacer maintains soft tissue tension and improves functional outcome during treatment. Static spacer or excision for definitive cases.
- Fitness for Revision
- Yes
- Microorganism
- Sensitive, identifiable
- Recommendation
- 2-stage with spacer preferred
- Fitness for Revision
- Limited
- Microorganism
- Resistant/fungal
- Recommendation
- Girdlestone (possibly definitive)
- Fitness for Revision
- Exhausted options
- Microorganism
- Any
- Recommendation
- Definitive Girdlestone
- Fitness for Revision
- No
- Microorganism
- Any
- Recommendation
- Definitive Girdlestone + suppression
RECLAIMKey Steps
Hook:RECLAIM the hip from infection!
SPACEGirdlestone vs Spacer
Hook:Use SPACE (spacer) if reimplantation planned!
Overview and Epidemiology
The Girdlestone procedure (excision arthroplasty) involves resection of the femoral head and neck without replacement. Originally described by Gathorne Robert Girdlestone for tuberculosis of the hip, it is now primarily used as a salvage procedure for periprosthetic joint infection (PJI) when other options have failed or are contraindicated.
G.R. Girdlestone (1881-1950) described excision arthroplasty in 1943 for tuberculosis of the hip. Pre-antibiotic era, it was the primary treatment for septic hip. Now reserved for salvage of infected arthroplasty or when patient is not a candidate for replacement.
- PJI: Failed DAIR or 2-stage
- Recurrent deep infection
- Not fit for revision surgery
- Resistant/difficult organisms
- Severe bone loss precluding reimplantation
- Native hip septic arthritis (failed treatment)
- Tuberculosis (historical, rare now)
- Severe avascular necrosis (not suitable for THR)
- Certain malignancies (palliation)
Indications and Contraindications
When to Consider Girdlestone
- Context
- Early infection, debridement insufficient
- Type
- Staging or definitive
- Context
- Recurrent infection despite reimplantation
- Type
- Definitive
- Context
- Fungal, MDR bacteria
- Type
- Definitive or long-term antibiotic
- Context
- High surgical risk, poor functional reserve
- Type
- Definitive
- Context
- Insufficient stock for reconstruction
- Type
- Definitive
- Context
- Unable to complete antibiotic course
- Type
- Definitive with suppression
DAIR (Debridement, Antibiotics, Implant Retention) failure is an indication. Failure criteria include: persistent positive cultures, sinus tract persistence, ongoing clinical infection, or CRP/ESR non-normalization despite adequate course.
Patient selection is critical - discuss functional expectations thoroughly.
RESCUEIndications for Girdlestone
Hook:When patient needs RESCUE from failed hip, consider Girdlestone!
Preoperative Planning
Preoperative Workup
Confirm diagnosis: Aspiration with culture (extend hold time for slow-growing organisms), inflammatory markers (CRP, ESR), imaging (XR, CT for bone loss). Apply MSIS criteria for PJI diagnosis.
ID the pathogen: Determines antibiotic selection and duration. Consider resistant organisms, fungi, or mycobacteria in refractory cases. Liaise with microbiology/ID early.
Optimize patient: Nutrition (albumin greater than 3g/dL, total lymphocyte count), glycemic control (HbA1c under 8%), smoking cessation. Address cardiac, renal comorbidities.
Plan approach: Review previous incisions. Assess bone loss on imaging. Discuss with patient: realistic functional expectations, need for aids, LLD. Consider if spacer or definitive.
Major criteria (1 = positive): Sinus communicating with prosthesis, OR same organism on 2 separate cultures. Minor criteria (3+ = positive): Elevated ESR/CRP, elevated synovial WCC, elevated synovial PMN%, positive histology, positive single culture. Be familiar with these criteria for diagnosis.
- CRP and ESR: Baseline, follow response
- Synovial fluid: WCC, differential, culture
- Blood cultures: If systemic symptoms
- Albumin/prealbumin: Nutrition status
- HbA1c: Glycemic control
- XR: Component loosening, bone loss
- CT: Bone defects, cement location
- MRI: Soft tissue collection (rare)
- Nuclear medicine: If diagnosis uncertain
Pathophysiology and Mechanisms
The abductor mechanism (gluteus medius/minimus inserting on greater trochanter) must be preserved for pseudarthrosis stability. Excessive bone resection results in proximal migration and worse function. The sciatic nerve is at risk and must be protected during posterior dissection.
- Preserve/Remove
- PRESERVE
- Rationale
- Abductor attachment crucial for stability
- Preserve/Remove
- REMOVE
- Rationale
- Source of infection, resect to healthy bone
- Preserve/Remove
- REMOVE
- Rationale
- Biofilm eradication requires complete removal
- Preserve/Remove
- PRESERVE
- Rationale
- Trendelenburg gait worsens if lost
- Preserve/Remove
- VARIABLE
- Rationale
- May help contain pseudarthrosis
After Girdlestone, a fibrous pseudarthrosis develops. The proximal femur migrates superiorly until it articulates with the ischium/ilium. Abductor function determines stability - if preserved, patient may achieve limited ambulation. LLD of 4-6cm is typical.
- Proximal femoral stump
- Fibrous pseudarthrosis
- Proximal migration (4-6cm)
- Acetabulum becomes defunctioned
- Weight bearing through ischium
- Positive Trendelenburg sign
- Marked limp
- Need for walking aids (cane or walker)
- Sitting tolerance usually preserved
- Severe restriction of activity
Classification Systems
Periprosthetic Joint Infection Classification
- Timing
- Less than 4 weeks post-op
- Typical Organism
- S. aureus, gram-negatives
- Management
- DAIR often successful
- Timing
- Greater than 4 weeks, less than 12 months
- Typical Organism
- S. epidermidis, low virulence
- Management
- DAIR may work, often 2-stage
- Timing
- Any time, acute onset
- Typical Organism
- S. aureus, streptococcus
- Management
- DAIR if less than 3 weeks symptoms
- Timing
- Established infection
- Typical Organism
- Any organism
- Management
- 2-stage or Girdlestone
DAIR success factors: Acute infection (less than 4 weeks), sensitive organism, well-fixed prosthesis, healthy host. Girdlestone indications: Failed DAIR, chronic infection, resistant organisms, poor host status.
Classification helps predict treatment success and guides surgical planning.
Clinical Assessment
- Presenting symptoms: Pain, swelling, sinus drainage
- Timeline: Acute vs chronic symptoms
- Previous surgeries: Number of revisions, organisms
- Antibiotic history: Previous treatments, allergies
- Comorbidities: Diabetes, immunosuppression
- Wound inspection: Sinus tract, drainage, erythema
- Joint assessment: Warmth, effusion, ROM
- Neurovascular: Sciatic nerve function
- Limb length: Current discrepancy
- Gait: Ambulatory status
- Significance
- Definitive for PJI
- Action Required
- No further testing needed for diagnosis
- Significance
- Highly suspicious
- Action Required
- Aspiration and imaging
- Significance
- Suggestive
- Action Required
- Full workup needed
- Significance
- Supportive evidence
- Action Required
- Correlate with clinical picture
A sinus tract communicating with the prosthesis is pathognomonic for periprosthetic joint infection. No further diagnostic tests are required - proceed directly to treatment planning.
Investigations
Diagnostic Workup
Inflammatory markers: CRP (most sensitive), ESR. Serial values help monitor treatment response. WCC often normal in chronic infection.
Synovial fluid analysis: WCC (greater than 3000/μL), PMN% (greater than 80%), culture (hold 14 days). Alpha-defensin if available.
Radiographs: Component loosening, periosteal reaction. CT: Bone loss assessment, cement location. Nuclear medicine: If diagnosis uncertain.
- Criteria
- Sinus tract OR 2+ cultures same organism
- Interpretation
- Definitive diagnosis
- Criteria
- Elevated ESR/CRP
- Interpretation
- Supportive evidence
- Criteria
- Elevated synovial WCC (greater than 3000)
- Interpretation
- Supportive evidence
- Criteria
- Elevated synovial PMN% (greater than 80%)
- Interpretation
- Supportive evidence
- Criteria
- Positive histology (greater than 5 PMN/HPF)
- Interpretation
- Supportive evidence
- Criteria
- Positive single culture
- Interpretation
- Supportive evidence
Extended culture (14 days) improves detection of slow-growing organisms like Propionibacterium acnes. Take samples BEFORE antibiotics. Minimum 5 tissue samples from different locations for optimal sensitivity.
Differential Diagnosis
A painful or failing hip arthroplasty is not always infected. Distinguishing PJI from aseptic causes is the pivotal decision before resection — an unnecessary Girdlestone for aseptic loosening is a catastrophic error.
- Discriminating Features
- Sinus, rest pain, raised CRP/ESR, early loosening
- Key Test
- Aspiration (synovial WCC/PMN%, culture), MSIS score
- Why It Matters
- Mandates debridement/resection, not simple revision
- Discriminating Features
- Activity-related pain, normal inflammatory markers
- Key Test
- Serial radiographs (lucency, migration), normal aspirate
- Why It Matters
- Treated by revision, NOT resection
- Discriminating Features
- Metal bearing, pseudotumour, rising cobalt/chromium
- Key Test
- Metal ions, MARS-MRI
- Why It Matters
- Revision of bearing, not infection pathway
- Discriminating Features
- Trauma, acute pain, deformity
- Key Test
- Radiographs, Vancouver classification
- Why It Matters
- Fixation/revision, not excision
- Discriminating Features
- Spinal stenosis, GTPS, hernia, vascular claudication
- Key Test
- Targeted exam, imaging, diagnostic injection
- Why It Matters
- Avoids unnecessary hip surgery
- Discriminating Features
- Mechanical clunk, recurrent subluxation
- Key Test
- Component-position CT, dynamic exam
- Why It Matters
- Component revision, not resection
Always exclude aseptic loosening, ALTR and extra-articular pain before committing to excision arthroplasty. A negative aspirate, normal CRP/ESR and no sinus point away from infection. Resection arthroplasty for a misdiagnosed aseptic hip needlessly inflicts permanent shortening and aid-dependence.
What Makes a 'Good' vs a 'Poor' Girdlestone: the Biomechanics of the Pseudarthrosis
The topic states that "abductor function determines stability", that "excessive bone resection results in proximal migration and worse function", and that only 50-60% are ambulatory - but never explains what the surgeon controls that separates a stable, walkable pseudarthrosis from a flail, painful, non-ambulatory one. This is the high-yield "why" behind the outcome figures.
- Resection level is the single biggest surgeon-controlled variable. The femur is resected only as far distal as infection/removal demands - conserving length keeps the femoral stump abutting the ischium/ilium rather than riding high. A high resection (short stump) allows greater proximal migration, worsens the lever arm and produces a longer, more unstable limb-shortening; a more distal, length-preserving resection (consistent with clearing the infection) gives a shorter migration and a more stable articulation. The 4-6 cm shortening is the price; making it worse than necessary is avoidable.
- The abductor lever arm is what powers gait. A pseudarthrosis is stabilised dynamically, not by bone - so an intact abductor complex on a preserved greater trochanter lets the patient generate a functional (if Trendelenburg) gait, whereas a detached/non-viable trochanter or a deficient abductor mass produces a flail hip, a lurching or non-functional gait and aid-dependence or wheelchair use. Preserving the trochanter and its attachment whenever it is viable is therefore a functional imperative, not a cosmetic one.
- Soft-tissue interposition and scar create the fibrous articulation. A broad, well-vascularised soft-tissue envelope between the proximal femur and pelvis (capsule remnants, vastus/glutei, sometimes a formal muscle interposition) matures into a stable fibrous pseudarthrosis and cushions the bone-on-bone contact that causes pain; extensive dead space or a bare femoral stump against pelvis gives instability and pain.
- Host and disease factors set the ceiling. Even with perfect technique, bilateral disease, poor abductors from prior surgery, neuromuscular disease, uncontrolled pain and low functional reserve cap the achievable result - which is why the honest counselling figure is "50-60% walk, with aids".
Q: What does the surgeon control that determines whether a Girdlestone hip is stable and walkable? A: Three things. (1) Resection level - resect only as far as infection clearance requires; a length-preserving resection keeps the stump against the pelvis and limits proximal migration, whereas a high/short stump gives more migration, more shortening and instability. (2) The abductor lever arm - a preserved, viable greater trochanter with intact abductors gives a functional Trendelenburg gait; a detached/deficient abductor mass gives a flail, non-ambulatory hip. (3) Soft-tissue interposition - a broad vascularised muscle/capsule envelope matures into a stable, less painful fibrous pseudarthrosis. Host factors (bilateral disease, neuromuscular status, reserve) then set the ceiling.
Converting a Girdlestone Back to a Hip: Delayed Reimplantation
The topic repeatedly frames the procedure as "interim" before reimplantation and contrasts "definitive" with "staged", but never describes the conversion operation itself - taking a healed excision arthroplasty back to a THA is a distinct, difficult undertaking that examiners probe, and its difficulty is exactly why definitive Girdlestone is sometimes accepted.
- When it is done, and the prerequisites. Conversion is considered once the infection is truly eradicated (normalised inflammatory markers, negative aspirate/intra-operative samples, an interval off antibiotics) in a host now fit and motivated for a major reconstruction. It is the "second stage" that a spacer was meant to facilitate - and the longer the hip has been left as a bare Girdlestone (no spacer), the harder it becomes.
- The soft tissues are the enemy. After months of a shortened, migrated hip the abductors and capsule contract and scar, the femur sits proximal, and restoring length re-tensions a chronically shortened neurovascular envelope - so conversion carries a real risk of sciatic/femoral nerve traction injury when length is regained, and full LLD correction is often not achievable in one sitting. Heterotopic bone and dense scar further obscure planes.
- Bone stock and fixation are compromised. Repeated debridements and the original resection leave deficient femoral and acetabular bone, frequently needing revision/reconstruction implants (long stems, cup-cage/augments, sometimes a proximal femoral replacement) rather than a primary THA.
- Abductor deficiency drives instability - the dominant complication. The scarred, shortened, often-deficient abductor mechanism makes the converted hip prone to dislocation, so constrained or dual-mobility bearings are frequently used; overall complication, dislocation and re-infection rates are markedly higher, and functional outcomes poorer, than a primary THA - though still usually better than a retained Girdlestone in a suitable host.
Q: What are the specific challenges of converting a healed Girdlestone to a THA? A: Only after confirmed infection eradication in a fit host. Expect contracted, scarred, deficient abductors and capsule (high dislocation risk - consider dual-mobility/constrained), proximal femoral migration so that regaining length risks sciatic/femoral nerve traction injury and full LLD correction is often incomplete, deficient femoral/acetabular bone stock needing revision implants (long stems, cup-cage/augments, sometimes proximal femoral replacement), and heterotopic bone/scar. Complication, dislocation and re-infection rates exceed a primary THA and function is poorer - which is part of why a definitive Girdlestone is accepted in the unfit or unreconstructable host.
Management Algorithm

Treatment Algorithm
Step 1: Confirm PJI Diagnosis
- Apply MSIS criteria
- Identify organism if possible
Step 2: Assess Patient Factors
- Medical fitness for surgery
- Bone stock quality
- Social support and compliance
- Functional expectations
Step 3: Treatment Selection
- Recommended Treatment
- DAIR first
- Rationale
- High success rate, preserves function
- Recommended Treatment
- 2-stage with spacer
- Rationale
- Good outcomes, aims for reimplantation
- Recommended Treatment
- Girdlestone (definitive)
- Rationale
- Prioritizes infection control
- Recommended Treatment
- Chronic suppression
- Rationale
- Palliative approach
Articulating spacer if reimplantation planned - maintains soft tissue tension, improves interim function. No spacer (Girdlestone) for definitive cases or when spacer stability is not achievable.
Multidisciplinary discussion with ID, microbiology, and patient is essential.
Surgical Technique
Setup and Approach
Positioning Steps
General or regional anesthesia. Prepare for potentially lengthy procedure. Adequate IV access and invasive monitoring if indicated. Administer antibiotics AFTER intraoperative cultures taken.
Lateral decubitus position is most common. Allows access to acetabulum and femur. Alternative: supine on fracture table if combined procedure. Secure pelvis with supports.
Standard prep and drape. Expose entire limb for length assessment. Mark previous incisions. Plan extensile approach if needed for cement removal.
Do not give antibiotics until intraoperative cultures taken. Collect minimum 5 tissue samples from different areas (synovium, capsule, bone-implant interface). Send for aerobic, anaerobic, and fungal cultures. Extended culture (14 days) for slow-growing organisms.
Prepare for extensile approach if cemented prosthesis with aggressive cement removal needed.
Complications
- Incidence
- 10-30%
- Prevention/Management
- Adequate debridement, appropriate antibiotics, suppression if needed
- Incidence
- 15-25%
- Prevention/Management
- Optimize nutrition, meticulous closure, manage dead space
- Incidence
- Common (inherent)
- Prevention/Management
- Expected outcome - brace/abduction pillow initially
- Incidence
- 5-10%
- Prevention/Management
- Careful technique, prophylactic fixation if needed
- Incidence
- 1-3%
- Prevention/Management
- Careful dissection, identify and protect nerve
- Incidence
- Variable
- Prevention/Management
- Chemical and mechanical prophylaxis
10-30% may have persistent infection despite adequate surgery. Risk factors: resistant organisms, inadequate debridement, retained cement/foreign material, immunocompromise. Options: repeat debridement, long-term suppression, or accept chronic wound.
If infection persists: (1) Confirm adequate initial debridement, (2) Review antibiotic sensitivity and compliance, (3) Consider repeat surgery for retained material, (4) Long-term oral antibiotic suppression may control but not eradicate infection.
Postoperative Care
Postoperative Protocol
Ward care: Pain management, wound monitoring. Begin DVT prophylaxis. Drain management. Hip abduction pillow or brace for comfort. IV antibiotics continue (based on cultures).
Mobilization: Sit out of bed day 1-2. Protected weight bearing with frame/crutches. Physiotherapy - maintain muscle function. Wound inspection. Staple removal 2 weeks.
Ongoing care: Continue IV antibiotics (typically 6 weeks minimum). Transition to oral antibiotics if appropriate. Progressive mobilization. Address LLD with shoe raise.
Recovery phase: Complete antibiotic course. Monitor inflammatory markers (CRP should normalize). Consider reimplantation if staged procedure. Finalize walking aids, orthotics.
Minimum 6 weeks IV antibiotics followed by oral therapy. Duration depends on organism, response, and whether reimplantation planned. Consult infectious diseases for regimen. Monitor for drug toxicity (aminoglycosides - renal/ototoxicity, rifampicin - hepatic).
- WBAT with aids - walker or crutches
- Hip abduction strengthening
- Gait training for LLD
- Shoe raise 3-5cm for LLD
- Progress to single cane over months
- CRP weekly initially, then monthly
- Wound assessment at each visit
- Imaging if concern for retained material
- Monitor antibiotic side effects
- Assess function and pain
Outcomes and Prognosis
- Girdlestone (Definitive)
- 70-80%
- 2-Stage with Reimplantation
- 75-85%
- Girdlestone (Definitive)
- 40-50
- 2-Stage with Reimplantation
- 70-85
- Girdlestone (Definitive)
- 50-60% (with aids)
- 2-Stage with Reimplantation
- 85-95%
- Girdlestone (Definitive)
- Variable
- 2-Stage with Reimplantation
- Higher
- Girdlestone (Definitive)
- 4-6cm
- 2-Stage with Reimplantation
- 1-2cm (correctable)
Definitive Girdlestone = significant disability. Most patients need walking aids permanently, have marked limp (Trendelenburg), and 4-6cm LLD. Pain relief is usually achieved. Sitting tolerance preserved. Better than ongoing sepsis but substantially worse than successful reimplantation.
- Pain control achieved
- Infection eradicated
- Independent in ADLs
- Ambulatory with aids
- Satisfied with outcome given alternatives
- Persistent infection
- Chronic wound/sinus
- Non-ambulatory
- Intractable pain
- Poor quality of life
Guidelines, Registries & Global Practice
Hip PJI affects roughly 1-2% of primary and up to 4-5% of revision total hip replacements worldwide. As arthroplasty volumes rise, the absolute burden of PJI is growing, and resection arthroplasty persists as the salvage of last resort across all health systems.
- Diagnostic Framework
- MSIS 2011 + 2018 validated weighted scoring; ICM consensus
- Position on Resection Arthroplasty
- Salvage for unreconstructable or multiply-failed PJI; spacer preferred if reimplantation feasible
- Diagnostic Framework
- Two-test screening (ESR + CRP), then aspiration; aligns with MSIS
- Position on Resection Arthroplasty
- Resection acceptable when host/limb cannot tolerate reconstruction
- Diagnostic Framework
- Multidisciplinary PJI MDT; aspiration before empirical antibiotics
- Position on Resection Arthroplasty
- Single- or two-stage favoured (INFORM RCT); resection reserved for non-reconstructable hips
- Diagnostic Framework
- EBJIS definition (confirmed/likely/unlikely PJI)
- Position on Resection Arthroplasty
- Resection or definitive Girdlestone for refractory infection or unfit host
- National registries (NJR England/Wales, AOANJRR, SHAR/Swedish, AJRR US, NZJR) track revision-for-infection rates
- Infection is a leading cause of early hip revision in all major registries
- Resection/excision is recorded but represents a small minority of revision outcomes
- Registry data confirm rising absolute PJI burden with increasing arthroplasty volume
- High-resource: 2-stage with antibiotic spacer, OPAT, alpha-defensin/D-dimer, specialist PJI MDT
- Limited-resource: Girdlestone often used as definitive primary salvage (no spacer, limited microbiology)
- TB and chronic septic native hip still managed by primary excision in endemic regions
- Prolonged IV antibiotics may be replaced by early oral therapy (OVIVA-supported) where OPAT unavailable
Examiners worldwide (FRCS, FRACS, EBOT, ABOS, DNB/MS) will expect: PJI diagnosis by MSIS/EBJIS criteria, the indication hierarchy (DAIR → single/two-stage → resection), surgical steps with the tissue-sampling protocol, antibiotic principles, and honest counselling of functional outcomes (shortening, Trendelenburg, aid-dependence).
Controversies & Areas of Uncertainty
With megaprostheses, cup-cage constructs and single-stage revision now feasible, the threshold for definitive excision keeps rising. Debate centres on whether borderline hosts are better served by a complex reconstruction attempt or by accepting a stable, infection-free pseudarthrosis.
Articulating spacers improve interim function and soft-tissue tension, but no high-level RCT proves superior infection eradication over a true Girdlestone. Spacer-related complications (dislocation, fracture, mechanical failure) are real, especially with major bone loss.
The INFORM RCT found no medium-term difference in patient-reported outcome between single- and two-stage hip revision, with single-stage offering faster recovery and lower cost. This narrows, but does not abolish, the role of staged management and resection.
Traditional 6-week IV courses are challenged by trial evidence (e.g. OVIVA) supporting early oral switch for bone and joint infection. Optimal duration after resection, and the value of lifelong suppression, remain unresolved.
MCQ Practice Points
Q: What is the most common indication for Girdlestone excision arthroplasty today? A: Periprosthetic joint infection (PJI) where DAIR has failed or is contraindicated, or as interim/definitive salvage for multiply recurrent infection. It was originally described for tuberculosis of the hip.
Q: What leg length discrepancy is typically expected after Girdlestone procedure? A: 4-6cm shortening - The proximal femur migrates superiorly until it articulates with the pelvis at a pseudarthrosis. This results in significant shortening requiring shoe raise and walking aids.
Q: How many tissue samples should be obtained during revision for PJI? A: Minimum 5 tissue samples from different locations (membrane, capsule, acetabulum, femoral canal, collections). Take BEFORE antibiotics. Send for aerobic, anaerobic, and extended culture.
Q: What is the main advantage of an articulating antibiotic spacer over Girdlestone as interim procedure? A: Maintains soft tissue tension - Preserves abductor length, improves interim function, and facilitates subsequent reimplantation by keeping soft tissues at appropriate tension and length.
Q: What are the major criteria for PJI diagnosis according to MSIS? A: Two major criteria: (1) Sinus tract communicating with the prosthesis, OR (2) Same organism isolated on 2 or more separate tissue/fluid samples. Either one confirms PJI.
Exam Viva Scenarios
Practise clinical reasoning and management decisions out loud
“A 72-year-old diabetic man has had 2 previous revisions for infected THA over 5 years. He now presents with recurrent infection (MRSA), draining sinus, and HbA1c of 9.5%. He is a widower living alone with minimal family support.”
“A 58-year-old otherwise healthy woman presents with infected THA (Staphylococcus epidermidis, susceptible) 2 years post primary. DAIR failed after 6 weeks. She is motivated for best functional outcome and wants to return to golf.”
“During first stage of 2-stage revision for PJI, you encounter severe acetabular bone loss with a cavitary defect and pelvic discontinuity. The femur has reasonable stock. What do you do?”
“Culture from hip aspiration grows Candida albicans in a 65-year-old immunocompetent patient with painful THA. No previous surgery. What is your management?”
Core Concepts
- Excision arthroplasty = SALVAGE for infected THA
- Named after GR Girdlestone (TB of hip, 1943)
- Can be DEFINITIVE or INTERIM (2-stage)
- Spacer preferred if reimplantation planned
Indications (RESCUE)
- Failed DAIR or 2-stage revision
- Resistant/difficult organisms (MDR, fungal)
- Medical comorbidities precluding revision
- Severe bone loss preventing reconstruction
Surgical Pearls
- 5+ tissue samples BEFORE antibiotics
- Remove ALL cement (biofilm reservoir)
- Preserve ABDUCTORS (stability of pseudarthrosis)
- Copious lavage (minimum 9L)
Outcomes
- Infection eradication: 70-80%
- LLD: 4-6cm (need shoe raise)
- 50-60% ambulatory with aids
- Harris Hip Score ~40-50 (vs 70-85 with reimplantation)
Exam Pearls
- MSIS criteria for PJI diagnosis
- Minimum 6 weeks IV antibiotics
- Trendelenburg gait expected
- Better than ongoing sepsis
Evidence Base
- Single-centre series of 88 patients (91 hips) with refractory PJI. Infection eradicated in 65/91 (71%). Mean limb shortening 5.7cm; mean walking distance 175m; mean Merle d'Aubigné-Postel score 9.3/18. Corticosteroid use (HR 6), preoperative fever (HR 4.1) and polymicrobial infection (HR 2.5) were independent predictors of failure. Infection-related mortality 7%.
- 28 hips in 26 patients treated by Girdlestone resection (mixed septic, tubercular, post-traumatic and CP indications). Pain relief in 84%; all patients required walking aids and all had a positive Trendelenburg sign. Mean limb shortening 3.8cm (range 1.5-6.5cm). Mean Harris Hip Score 64 (range 25-83); no excellent outcomes. 74% satisfied given alternatives.
- 25 knees treated with resection arthroplasty for recalcitrant PJI after a mean of 5 prior operations. 84% free of infection at mean 4-year follow-up; only 1 amputation. 45% community ambulators, 35% household, 20% transfer-only — all required bracing and assistive devices.
- Pragmatic multicentre RCT of 140 patients with hip PJI. No difference in WOMAC at 18 months between single- and two-stage revision; single-stage was better at 3 months, had fewer intraoperative complications (8% vs 27%) and was cost-effective. Markers of possible ongoing infection were similar (14% vs 11%).
- Original standardized MSIS definition of PJI. Major criteria: sinus tract communicating with prosthesis, OR same organism on 2 separate cultures. Minor criteria (4 of 6): elevated ESR/CRP, elevated synovial WCC, elevated synovial PMN%, positive histology, single positive culture, purulence.
- Evidence-based, externally validated scoring system. Major criteria (sinus tract or 2 positive cultures) remain diagnostic. Weighted minor criteria: serum CRP/D-dimer/ESR and synovial WCC, alpha-defensin, leukocyte esterase, PMN%, synovial CRP; aggregate score of 6 or more = infected. Sensitivity 97.7% vs 79.3% for the 2011 MSIS criteria.
- 489 joints across 24 studies. Candida albicans was the commonest organism (41.5%); 50.5% had concurrent bacterial coinfection. Recurrence by strategy: DAIR 81.4%, resection arthroplasty 53.1%, two-stage 47.7%. Mean systemic antifungal duration 12.8 weeks (fluconazole commonest); amphotericin B was the dominant cement additive.