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Humeral Shaft Fracture Fixation (Plating vs Nailing)

Operative SurgeryTrauma
TraumaIntermediateCore Procedure

Humeral Shaft Fracture Fixation (Plating vs Nailing)

Surgical technique guide for humeral shaft fracture fixation - operative versus conservative (Sarmiento bracing) decision-making, anterolateral/posterior/MIPO approaches, radial nerve protection, and compression plating versus intramedullary nailing

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Peer-reviewed Β· 2026-06-20
High-yield overview

Operative versus functional bracing, and compression plating versus intramedullary nailing for diaphyseal humeral fractures

traumaSubspecialty
about 90%Brace union
radial n.Key danger
60-90 minTypical duration
Critical Must-Knows
  • Most humeral shaft fractures heal non-operatively in a functional (Sarmiento) brace. Acceptable alignment is generous because of shoulder and elbow compensation and the surrounding soft-tissue sleeve: up to about 20 degrees anterior angulation, 30 degrees varus or valgus angulation, and 3 cm shortening are well tolerated cosmetically and functionally.
  • The radial nerve is the central theme. It runs in the spiral groove on the posterior humerus, crosses from the medial to the lateral side at roughly the middle-to-distal third junction, and pierces the lateral intermuscular septum about 10 cm proximal to the lateral epicondyle. A distal-third spiral fracture (Holstein-Lewis) is the pattern classically associated with radial nerve palsy.
  • Most primary radial nerve palsies are neuropraxia and recover spontaneously β€” around 90 percent by 3 to 4 months. The default is observation with a baseline and serial examination and EMG/NCS at about 6 weeks and 3 months. Early exploration is reserved for an open fracture, penetrating trauma, or a palsy that develops after closed reduction or manipulation.
  • Compression plating through an open approach is the long-standing reference standard with low nonunion and shoulder-sparing outcomes; intramedullary nailing competes on biology and load-sharing but antegrade nailing risks rotator-cuff and shoulder morbidity. Meta-analyses favour plating for shoulder function and lower reoperation.
Clinical Pearls
  • β€œ
    Operative indications: open fracture, vascular injury, polytrauma or floating elbow, bilateral humeral fractures, pathological or impending fracture, segmental fracture, failure to maintain acceptable reduction in a brace, and selected radial nerve palsies (open injury, post-penetrating trauma, or palsy after manipulation equals explore).
  • β€œ
    Radial nerve palsy present at injury (primary) in a closed fracture equals observe; palsy that appears after you reduce or manipulate (secondary) equals explore β€” the nerve may be entrapped or transected by the manoeuvre.
  • β€œ
    Approach by fracture level: anterolateral (Henry-type extension) for proximal and mid shaft; posterior (triceps-splitting or paratricipital) for the distal third where you must identify the radial nerve; MIPO anterolateral keeps an extraperiosteal plane and protects the nerve.
  • β€œ
    Nailing earns its place in pathological, segmental, and osteopenic fractures (load-sharing, less soft-tissue stripping); plating wins for primary radial nerve palsies needing exploration, distal-third fractures, and when shoulder function is paramount.

When & Why


The central decision. The default for an isolated, closed humeral shaft fracture with acceptable alignment is non-operative treatment in a functional (Sarmiento) brace. The humerus is a non-weight-bearing bone surrounded by generous soft tissue, and the shoulder and elbow compensate for residual deformity, so union rates with bracing are high (commonly quoted around 90 percent in classic series) with good functional outcomes. The FISH randomised trial confirmed that bracing and plating give similar 12-month function in closed fractures, though bracing carries a higher secondary-surgery rate for nonunion. Acceptable alignment (the limits in a brace). Deformity within these limits is cosmetically and functionally acceptable, and it is failure to maintain these limits β€” not minor in-range angulation β€” that triggers operative conversion.

  • Up to about 20 degrees anterior angulation
  • Up to about 30 degrees varus or valgus angulation
  • Up to about 3 cm shortening
  • Rotational malalignment is also generally well tolerated Functional bracing protocol (Sarmiento).
  • Initial management in a coaptation (U-slab) splint or hanging cast for 1 to 2 weeks to settle pain and swelling
  • Transition to a prefabricated functional brace once acute swelling subsides
  • The brace works by soft-tissue compression (the hydraulic effect) maintaining alignment while gravity provides traction; early shoulder pendulum and elbow motion are encouraged
  • Weekly radiographs initially to confirm alignment stays within acceptable limits
  • Brace continued until clinical and radiographic union (typically 8 to 12 weeks) Operative indications β€” patient and injury factors that mandate or favour surgery.
  • Open fracture (debridement plus stabilisation)
  • Vascular injury requiring repair β€” stabilise the bone to protect the vascular reconstruction
  • Polytrauma β€” fixation permits early mobilisation, frees the limb for weight-bearing through aids, and aids nursing
  • Floating elbow (ipsilateral humeral and forearm fracture)
  • Bilateral humeral shaft fractures (bracing both is impractical)
  • Pathological or impending pathological fracture
  • Segmental fracture
  • Failure to maintain acceptable reduction in a brace (loss of position beyond the limits above)
  • Inability to tolerate or comply with bracing (for example large body habitus, significant soft-tissue interposition, cognitive or social factors)
  • Selected radial nerve palsies β€” open injury, after penetrating trauma, or a palsy that develops after closed reduction or manipulation (explore) Radial nerve palsy β€” the decision logic.
  • Primary palsy in a closed fracture: observe. About 90 percent are neuropraxia or axonotmesis that recover spontaneously by 3 to 4 months. Document a baseline examination, splint the wrist and fingers to prevent contracture, and obtain EMG/NCS at around 6 weeks and 3 months to track recovery.
  • Secondary palsy (after reduction or manipulation): explore β€” the nerve may be entrapped in the fracture or have been injured by the manoeuvre.
  • Open fracture or penetrating trauma with palsy: explore the nerve at the time of debridement and fixation.
Typical candidate
Functional brace (Sarmiento)
Isolated closed fracture, acceptable alignment, compliant patient
Operative fixation
Open / vascular / polytrauma / segmental / pathological / unacceptable alignment
Union rate
Functional brace (Sarmiento)
High (around 90% in classic series)
Operative fixation
High with appropriate technique (plate or nail)
Acceptable deformity
Functional brace (Sarmiento)
Up to about 20 deg anterior, 30 deg varus, 3 cm short
Operative fixation
Anatomical or near-anatomical restoration aimed for
Shoulder and elbow
Functional brace (Sarmiento)
Early motion encouraged; usually good
Operative fixation
Plate spares shoulder; antegrade nail risks shoulder pain
Main drawback
Functional brace (Sarmiento)
Brace intolerance, malunion, needs compliance
Operative fixation
Surgical risks: radial nerve, infection, nonunion at a gap
Radial nerve palsy
Functional brace (Sarmiento)
Observe a primary closed palsy
Operative fixation
Explore for open injury, penetrating trauma, or post-manipulation palsy
Operative versus conservative management β€” decision summary
FactorFunctional brace (Sarmiento)Operative fixation
Typical candidateIsolated closed fracture, acceptable alignment, compliant patientOpen / vascular / polytrauma / segmental / pathological / unacceptable alignment
Union rateHigh (around 90% in classic series)High with appropriate technique (plate or nail)
Acceptable deformityUp to about 20 deg anterior, 30 deg varus, 3 cm shortAnatomical or near-anatomical restoration aimed for
Shoulder and elbowEarly motion encouraged; usually goodPlate spares shoulder; antegrade nail risks shoulder pain
Main drawbackBrace intolerance, malunion, needs complianceSurgical risks: radial nerve, infection, nonunion at a gap
Radial nerve palsyObserve a primary closed palsyExplore for open injury, penetrating trauma, or post-manipulation palsy
Pathological or impending fracture β€” never fix without a diagnosis

A fracture through a lytic or blastic lesion, or any low-energy fracture in a known cancer or myeloma patient, must be staged and, if the primary is unknown, biopsied before fixation. A solitary destructive lesion could be a primary bone sarcoma, and inappropriate intramedullary nailing of a sarcoma contaminates the entire medullary canal β€” a disaster. Image the whole bone, stage with CT chest/abdomen/pelvis and a bone scan, biopsy if uncertain, and discuss at the orthopaedic oncology MDT. For an impending (not yet fractured) lesion, apply a scoring tool such as Mirels to decide on prophylactic fixation.

The Operation


The goal is to expose the relevant level of the shaft, identify and protect the radial nerve, reduce the fracture, and apply stable fixation β€” plating for the reference-standard open technique that also allows nerve exploration, or nailing where its biology and load-sharing are advantageous. The exposure defines the operation: the radial nerve runs in the spiral groove, crosses to lateral at the middle-to-distal third, and pierces the lateral intermuscular septum 10 cm above the lateral epicondyle, so the approach is chosen by fracture level and the nerve is protected in every posterior and distal-third exposure.

Humeral shaft plating
Humeral shaft fracture fixed with a compression plate.Credit: OrthoVellum surgical illustration

Operative sequence (anterolateral plating is shown; nailing is the alternative at Step 8)

Step 1Position and choose the approach by fracture level
  • Decide by level: anterolateral (Henry-type, extensile) for proximal and middle third; posterior (triceps-splitting or paratricipital) for the distal third where the radial nerve must be identified; MIPO anterolateral for proximal and middle third where biology preservation matters.
  • Position accordingly: supine with the arm on a hand table for anterolateral and MIPO approaches; lateral decubitus or prone over a bolster for the posterior approach.
  • Apply a tourniquet (sterile if needed) and position fluoroscopy to give reliable AP and lateral views of the shaft.
Step 2Landmarks and incision
  • Anterolateral: an incision along the lateral border of biceps and brachialis over the fracture, extensile proximally into the deltoid-pectoralis interval and distally as a Henry approach.
  • Posterior: a longitudinal midline posterior incision over the fracture and distal shaft.
  • MIPO: short proximal and distal windows away from the fracture itself, so the fracture haematoma and biology are preserved.
Step 3Know the radial nerve before you cut β€” the structure that defines the operation
  • The radial nerve is the continuation of the posterior cord of the brachial plexus; it enters the posterior compartment and descends in the spiral (radial) groove on the posterior humerus with the profunda brachii artery, between the lateral and medial heads of triceps.
  • It crosses from medial to lateral at roughly the middle-to-distal third junction.
  • It then pierces the lateral intermuscular septum about 10 cm proximal to the lateral epicondyle, entering the anterior compartment between brachialis and brachioradialis.
  • Surgical relevance: it lies directly against bone in the groove (the posterior-approach hazard) and is tented over the lateral septum distally (the Holstein-Lewis hazard).
Step 4Expose and protect the radial nerve
  • In every posterior and distal-third exposure, identify and mobilise the nerve before applying a plate or drilling any screw.
  • Anterolateral: identify the nerve distally where it crosses laterally as you split brachialis, and protect it.
  • Posterior triceps-splitting: find it in the spiral groove proximally; proximal extension is limited because the nerve crosses the field.
  • Posterior paratricipital: work around the medial and lateral borders of triceps, mobilising the nerve to allow more proximal extension without splitting the muscle.
  • MIPO: respect the distal window β€” the nerve crosses laterally here and is the structure at risk.
  • Pass a vessel loop and keep the nerve clear of the plate edge throughout.
Step 5Deep dissection to the shaft (internervous planes)
  • Anterolateral: split brachialis β€” the lateral half is supplied by the radial nerve and the medial half by the musculocutaneous nerve, so this dual innervation protects against complete denervation; proximally the plane is between deltoid (axillary) and pectoralis major.
  • Posterior: split between or through the triceps heads, or go paratricipital around the muscle borders.
  • MIPO: an extraperiosteal submuscular plane along the anterior humerus, deep to brachialis.
  • The brachial artery and median and ulnar nerves lie medially in the neurovascular bundle (a medial approach is rarely used); the musculocutaneous nerve supplying biceps and brachialis lies anteriorly and is protected by working lateral to brachialis.
Step 6Reduce the fracture
  • Restore length, alignment and rotation.
  • For a simple oblique or spiral pattern, place a lag screw across the fracture.
  • For a comminuted or segmental pattern, bridge without disturbing the fracture biology (relative stability).
  • Avoid distraction at the fracture site β€” over-lengthening from a brace, a gap left at plating, or a nail that distracts is a leading cause of nonunion.
Step 7Apply the compression plate (the reference standard)
  • Use a 4.5 mm broad or narrow LC-DCP or a locking compression plate.
  • Aim for absolute stability in simple (transverse, short oblique) patterns β€” anatomical reduction with interfragmentary compression (a lag screw plus a neutralisation plate, or dynamic compression through the plate).
  • Aim for relative stability (bridge plating) in comminuted or segmental patterns β€” restore length, alignment and rotation while preserving fracture-site biology.
  • Minimum fixation: aim for at least 6 cortices (3 bicortical screws) on each side of the fracture, more in osteopenic or comminuted bone.
  • Confirm reduction, alignment, rotation and hardware position on fluoroscopy and re-check that the radial nerve is free and uninjured before closure.
Step 8Alternative: intramedullary nailing (when biology and load-sharing win)
  • A load-sharing intramedullary device, placed with limited fracture-site exposure β€” best for pathological, impending, segmental and osteopenic fractures and the polytrauma patient.
  • Antegrade entry is at the medial edge of the supraspinatus footprint just off the articular margin; its chief drawback is rotator-cuff and shoulder pain, so a correct entry, a buried nail and a meticulous cuff repair are essential.
  • Retrograde entry is through the posterior distal humerus proximal to the olecranon fossa; it avoids the shoulder but risks a supracondylar fracture or distal-cortex blow-out at the entry site and is unsuitable for very distal fractures.
  • Locking screws proximally and distally control length and rotation; the radial nerve is not exposed, so iatrogenic risk is at open reduction or distal locking rather than during plating.
Step 9Closure and confirm nerve function
  • Close in layers; ensure the radial nerve is not kinked over the plate edge.
  • Document radial nerve function in recovery β€” a new post-operative deficit must be distinguished from a pre-existing one and prompts early exploration.
Anterolateral
Best fracture level
Proximal and middle third
Internervous / plane
Deltoid/pectoralis proximally; split brachialis distally
Radial nerve handling
Identify distally where it crosses lateral; protect during the brachialis split
Posterior (triceps-splitting)
Best fracture level
Distal third and distal humerus
Internervous / plane
Through the triceps heads
Radial nerve handling
MUST identify and protect in the spiral groove; it crosses the field
Posterior (paratricipital)
Best fracture level
Distal third needing proximal extension
Internervous / plane
Around the medial and lateral triceps borders
Radial nerve handling
Mobilise the nerve; allows more proximal extension
MIPO anterolateral
Best fracture level
Proximal and middle third
Internervous / plane
Extraperiosteal, submuscular, anterior
Radial nerve handling
Protect at the distal window; less direct dissection
Anteromedial / medial
Best fracture level
Selected (e.g. with vascular repair)
Internervous / plane
Medial
Radial nerve handling
Avoid the neurovascular bundle (brachial artery, median/ulnar nerves)
Surgical approaches by fracture level
ApproachBest fracture levelInternervous / planeRadial nerve handling
AnterolateralProximal and middle thirdDeltoid/pectoralis proximally; split brachialis distallyIdentify distally where it crosses lateral; protect during the brachialis split
Posterior (triceps-splitting)Distal third and distal humerusThrough the triceps headsMUST identify and protect in the spiral groove; it crosses the field
Posterior (paratricipital)Distal third needing proximal extensionAround the medial and lateral triceps bordersMobilise the nerve; allows more proximal extension
MIPO anterolateralProximal and middle thirdExtraperiosteal, submuscular, anteriorProtect at the distal window; less direct dissection
Anteromedial / medialSelected (e.g. with vascular repair)MedialAvoid the neurovascular bundle (brachial artery, median/ulnar nerves)
Plate when...

The fracture is in the distal third, the patient has a primary radial nerve palsy that needs exploration, the shoulder is functionally critical, or you need absolute stability for a simple pattern. Plating spares the shoulder and allows direct nerve handling.

Nail when...

The fracture is pathological, impending, segmental or osteopenic, or the patient is polytraumatised. The nail is load-sharing, protects the whole bone length (which may harbour further deposits), and allows immediate use with smaller incisions.

MIPO when...

A proximal or middle-third fracture needs plating but biology preservation matters. An extraperiosteal submuscular plate through proximal and distal windows gives plating's stability with reduced biological insult and avoids shoulder violation β€” provided the distal window respects the radial nerve.

Biomechanics
Compression plate (ORIF)
Absolute or relative stability; acts as a tension band on the lateral cortex
Intramedullary nail
Load-sharing intramedullary splint
Soft tissue / biology
Compression plate (ORIF)
More exposure (less with MIPO)
Intramedullary nail
Less fracture-site stripping
Radial nerve
Compression plate (ORIF)
Allows direct exploration and protection
Intramedullary nail
Not exposed; iatrogenic risk at open reduction or locking
Shoulder
Compression plate (ORIF)
Spared
Intramedullary nail
Antegrade: cuff injury and impingement pain
Nonunion / reoperation
Compression plate (ORIF)
Lower in pooled data
Intramedullary nail
Higher reoperation and shoulder complications
Best indications
Compression plate (ORIF)
Distal third, primary nerve palsy needing exploration, shoulder-critical patient
Intramedullary nail
Pathological, segmental, osteopenic, polytrauma
Compression plating versus intramedullary nailing
FeatureCompression plate (ORIF)Intramedullary nail
BiomechanicsAbsolute or relative stability; acts as a tension band on the lateral cortexLoad-sharing intramedullary splint
Soft tissue / biologyMore exposure (less with MIPO)Less fracture-site stripping
Radial nerveAllows direct exploration and protectionNot exposed; iatrogenic risk at open reduction or locking
ShoulderSparedAntegrade: cuff injury and impingement pain
Nonunion / reoperationLower in pooled dataHigher reoperation and shoulder complications
Best indicationsDistal third, primary nerve palsy needing exploration, shoulder-critical patientPathological, segmental, osteopenic, polytrauma
Radial nerve β€” the critical safety step

Before any plating or drilling in a posterior or distal-third exposure, identify and mobilise the radial nerve along its course, pass a vessel loop, and keep it clear of the plate edge. The nerve lies directly against bone in the spiral groove and is tented over the lateral intermuscular septum 10 cm above the lateral epicondyle β€” never drill or place screws blindly against the posterior cortex. A new post-operative or post-manipulation palsy means the nerve may be entrapped or kinked, and mandates exploration.

Holstein-Lewis β€” the classic palsy pattern

A spiral fracture of the distal third can tent, entrap or lacerate the radial nerve as it pierces the lateral intermuscular septum. A palsy in this pattern is usually still a neuropraxia that recovers, but a palsy appearing after manipulation, or in an open or penetrating injury, mandates exploration.

Why meta-analyses favour plating for the shoulder

Antegrade nailing passes through or near the supraspinatus footprint and articular cartilage. Poor entry or proud hardware causes persistent shoulder pain and impingement β€” the commonest morbidity of antegrade nailing (up to about 30 percent). Use a correct medial entry just off the articular margin, bury the nail beneath the cartilage, and meticulously repair the rotator cuff.

Aftercare & Complications


Rehabilitation | Phase | Timing | Immobilisation / activity | Therapy focus | |-------|--------|---------------------------|---------------| | 1 | Day 0 to 14 | Sling for comfort after fixation; functional brace for non-operative cases | Early controlled shoulder and elbow motion as stability permits; wound check | | 2 | 2 to 6 weeks | Removable sling / brace; protect the shoulder after antegrade nailing while the cuff heals | Active-assisted shoulder and elbow ROM; maintain reduction on weekly films (braced cases) | | 3 | 6 to 8 weeks | Brace until union (8 to 12 weeks) for non-operative cases | Progressive active ROM; begin strengthening as union progresses | | 4 | 8 to 16 weeks | Union expected; night splint only if needed | Strengthening; graded return to function; contact or manual work once radiographically united | Most patients return to light activity early; heavier loading and contact or manual work are deferred until radiographic union (commonly 10 to 16 weeks). Radial nerve palsy rehabilitation. Fit a dynamic or static wrist and finger extension (cock-up) splint to prevent a flexion contracture while awaiting recovery, maintain passive ROM of the wrist and fingers, and monitor with serial examination β€” an advancing Tinel's sign down the forearm signals regeneration. EMG/NCS at about 6 weeks and 3 months tracks reinnervation; the first sign of recovery is usually return of brachioradialis and wrist extension, then finger and thumb extension. If there is no recovery by 3 to 4 months or EMG shows no reinnervation, explore; if the nerve is not reconstructable, plan tendon transfers (for example PT to ECRB, FCR or FCU to EDC, and PL to EPL).

Radial nerve injury (primary)
Incidence
About 12% of shaft fractures
Recognition
Wrist drop, loss of finger and thumb MCP extension, sensory loss over the first dorsal web space at presentation
Prevention and management
Document a baseline exam before and after reduction. If a closed fracture with a primary palsy, observe (about 90% recover by 3 to 4 months); splint to prevent contracture; EMG/NCS at 6 weeks and 3 months; explore only if no recovery by 3 to 4 months or per indications
Radial nerve injury (iatrogenic / secondary)
Incidence
Plating about 5 to 10% transient; secondary palsy after manipulation variable
Recognition
A new deficit after reduction or manipulation, or after surgery, that was not present pre-operatively
Prevention and management
Identify and protect the nerve in posterior and distal-third approaches; respect the MIPO distal window. Explore a new post-manipulation or post-operative palsy (the nerve may be entrapped or kinked over the plate); repair or decompress as required
Nonunion
Incidence
Brace about 2 to 10%; surgery about 2 to 15% (higher distal third, transverse, distraction)
Recognition
Persistent pain and motion at the fracture site beyond expected union time; no bridging callus on serial radiographs
Prevention and management
Avoid distraction (compress transverse patterns; avoid over-distraction with a nail or brace); preserve biology. Gold-standard treatment is revision ORIF with compression plating plus autologous bone graft; exclude infection first
Infection
Incidence
ORIF about 1 to 5%; higher in open fractures
Recognition
Erythema, warmth, discharge, raised inflammatory markers, persistent pain, loosening on imaging
Prevention and management
Prophylactic antibiotics, meticulous technique, thorough debridement of open fractures. Debridement with culture-directed antibiotics; retain stable implants if union is progressing (DAIR), revise or remove if loose or established deep infection
Shoulder pain / impingement (antegrade nail)
Incidence
Up to about 30% with antegrade nailing
Recognition
Anterolateral shoulder pain, painful arc, restricted abduction and forward flexion after an antegrade nail
Prevention and management
Correct medial entry off the articular margin, bury the nail beneath cartilage, repair the rotator cuff. Physiotherapy; subacromial injection; nail removal once united if symptoms persist
Elbow / shoulder stiffness
Incidence
Variable; more with prolonged immobilisation
Recognition
Loss of elbow flexion or extension or shoulder ROM at follow-up despite union
Prevention and management
Early protected motion of shoulder and elbow; avoid unnecessary immobilisation. Structured physiotherapy; rarely arthrolysis for an established refractory contracture
Distal cortex blow-out / supracondylar fracture (retrograde nail)
Incidence
1 to 5% at retrograde entry
Recognition
Iatrogenic fracture propagation at the posterior distal entry portal seen intra-operatively or on post-op films
Prevention and management
Adequate entry portal size, correct trajectory, avoid forceful nail insertion. Supplementary fixation of the distal fragment; convert to plating if comminuted
Hardware prominence / failure
Incidence
Variable
Recognition
Pain over the plate, screw back-out, plate fracture in delayed or nonunion; broken locking bolts on a nail
Prevention and management
Adequate fixation length and screw number; address nonunion early before hardware fatigue. Implant removal once united; revision fixation plus grafting if failure occurs before union
Complications β€” recognition, prevention and management
ComplicationIncidenceRecognitionPrevention and management
Radial nerve injury (primary)About 12% of shaft fracturesWrist drop, loss of finger and thumb MCP extension, sensory loss over the first dorsal web space at presentationDocument a baseline exam before and after reduction. If a closed fracture with a primary palsy, observe (about 90% recover by 3 to 4 months); splint to prevent contracture; EMG/NCS at 6 weeks and 3 months; explore only if no recovery by 3 to 4 months or per indications
Radial nerve injury (iatrogenic / secondary)Plating about 5 to 10% transient; secondary palsy after manipulation variableA new deficit after reduction or manipulation, or after surgery, that was not present pre-operativelyIdentify and protect the nerve in posterior and distal-third approaches; respect the MIPO distal window. Explore a new post-manipulation or post-operative palsy (the nerve may be entrapped or kinked over the plate); repair or decompress as required
NonunionBrace about 2 to 10%; surgery about 2 to 15% (higher distal third, transverse, distraction)Persistent pain and motion at the fracture site beyond expected union time; no bridging callus on serial radiographsAvoid distraction (compress transverse patterns; avoid over-distraction with a nail or brace); preserve biology. Gold-standard treatment is revision ORIF with compression plating plus autologous bone graft; exclude infection first
InfectionORIF about 1 to 5%; higher in open fracturesErythema, warmth, discharge, raised inflammatory markers, persistent pain, loosening on imagingProphylactic antibiotics, meticulous technique, thorough debridement of open fractures. Debridement with culture-directed antibiotics; retain stable implants if union is progressing (DAIR), revise or remove if loose or established deep infection
Shoulder pain / impingement (antegrade nail)Up to about 30% with antegrade nailingAnterolateral shoulder pain, painful arc, restricted abduction and forward flexion after an antegrade nailCorrect medial entry off the articular margin, bury the nail beneath cartilage, repair the rotator cuff. Physiotherapy; subacromial injection; nail removal once united if symptoms persist
Elbow / shoulder stiffnessVariable; more with prolonged immobilisationLoss of elbow flexion or extension or shoulder ROM at follow-up despite unionEarly protected motion of shoulder and elbow; avoid unnecessary immobilisation. Structured physiotherapy; rarely arthrolysis for an established refractory contracture
Distal cortex blow-out / supracondylar fracture (retrograde nail)1 to 5% at retrograde entryIatrogenic fracture propagation at the posterior distal entry portal seen intra-operatively or on post-op filmsAdequate entry portal size, correct trajectory, avoid forceful nail insertion. Supplementary fixation of the distal fragment; convert to plating if comminuted
Hardware prominence / failureVariablePain over the plate, screw back-out, plate fracture in delayed or nonunion; broken locking bolts on a nailAdequate fixation length and screw number; address nonunion early before hardware fatigue. Implant removal once united; revision fixation plus grafting if failure occurs before union
Nonunion β€” the classic pattern and the fix

The distal-third transverse fracture is the classic humeral nonunion, and distraction is a leading cause. Confirm or exclude infection first (inflammatory markers, consider deep sampling), then revise with compression plating to correct any distraction and achieve absolute stability, adding autologous (iliac crest) bone graft for atrophic patterns. Exchange a failed nail for a compression plate where the nail has not controlled the nonunion.

Viva & Exam Focus


Mnemonic

OPERATEOPERATE β€” Indications for surgical fixation

O
Open fracture or vascular injury
Debride and stabilise; fix the bone to protect the vascular repair
P
Polytrauma or floating elbow
Ipsilateral forearm fracture β€” fixation allows mobilisation and frees the limb
E
Extra (bilateral) or pathological
Bilateral humeral fractures, or a pathological or impending fracture β€” bracing is impractical or unsafe
R
Radial nerve palsy to explore
Open injury, after penetrating trauma, or a palsy appearing after manipulation
A
Alignment unacceptable
Failure to maintain reduction in a brace (beyond 20 deg anterior, 30 deg varus, 3 cm short)
T
Transverse or segmental high-risk pattern
Or inability to tolerate or comply with a brace (obesity, large soft-tissue interposition, dependency)
E
Extension into joint or associated injuries
Articular extension or associated injuries best served by stable internal fixation
Mnemonic

RADIALRADIAL β€” Managing the radial nerve

R
Record a baseline exam
Motor and sensory, before and after any reduction β€” wrist, finger and thumb extension and first dorsal web sensation
A
Anatomy
Spiral groove posteriorly; crosses to lateral at the middle-to-distal third; pierces the lateral intermuscular septum about 10 cm above the lateral epicondyle
D
Distal-third spiral (Holstein-Lewis)
The classic palsy pattern β€” examine carefully and document
I
Identify and protect
In every posterior approach and at distal-third plating, before drilling
A
After manipulation a new palsy equals explore
An open or penetrating injury also equals explore
L
Leave most primary closed palsies
Observe β€” about 90% recover by 3 to 4 months; EMG/NCS at 6 weeks and 3 months

Clinical Decision Scenarios

Practise clinical reasoning and management decisions out loud

Viva scenarioStandard
Clinical prompt

β€œA 35-year-old man falls and sustains a closed mid-shaft humeral fracture. He has a complete wrist drop with loss of finger and thumb extension and numbness over the first dorsal web space. Radiographs show a spiral mid-to-distal-third fracture in acceptable alignment. How do you manage him?”

Viva scenarioStandard
Clinical prompt

β€œYou have decided to operate on a distal-third humeral shaft fracture in a 50-year-old woman who has unacceptable alignment in a brace and intact radial nerve function. Would you plate or nail this fracture, and how do you protect the radial nerve?”

Viva scenarioStandard
Clinical prompt

β€œA 68-year-old woman with known breast cancer presents with a mid-shaft humeral fracture after minimal trauma. Radiographs show a lytic lesion at the fracture site. How does your management differ from a routine fracture, and what fixation would you choose?”

Exam day cheat sheet
Humeral shaft fracture fixation β€” exam-day essentials

The central decision

  • Default for an isolated closed fracture with acceptable alignment is a functional (Sarmiento) brace; union around 90%
  • Acceptable alignment: up to about 20 deg anterior, 30 deg varus or valgus, 3 cm shortening
  • The brace works by soft-tissue compression plus gravity traction; early shoulder and elbow motion; union 8 to 12 weeks
  • It is failure to maintain these limits β€” not minor in-range deformity β€” that triggers surgery
  • FISH trial: similar 12-month function for brace versus plate in closed fractures; bracing has a higher secondary-surgery rate

Operative indications

  • Open fracture; vascular injury requiring repair
  • Polytrauma; floating elbow; bilateral humeral fractures
  • Pathological or impending fracture; segmental fracture
  • Failure to maintain acceptable reduction in a brace; brace intolerance or non-compliance
  • Selected radial nerve palsies: open injury, penetrating trauma, or a palsy after manipulation

Radial nerve

  • Runs in the spiral groove with the profunda brachii; crosses medial-to-lateral at the middle-to-distal third
  • Pierces the lateral intermuscular septum about 10 cm proximal to the lateral epicondyle
  • Holstein-Lewis distal-third spiral fracture is the classic palsy pattern
  • Primary palsy in a closed fracture equals observe (about 90% recover by 3 to 4 months); EMG/NCS at 6 weeks and 3 months
  • Secondary palsy (after manipulation), open injury, or penetrating trauma equals EXPLORE

Surgical approaches

  • Anterolateral: proximal and middle third; split brachialis (radial n. lateral, musculocutaneous n. medial)
  • Posterior triceps-splitting: distal third β€” MUST identify the radial nerve in the spiral groove
  • Posterior paratricipital: more proximal extension by mobilising the nerve around triceps
  • MIPO anterolateral: extraperiosteal submuscular plate; protect the radial nerve at the distal window
  • Identify and protect the radial nerve in every posterior and distal-third exposure before drilling

Plating versus nailing

  • Plating is the reference standard: absolute stability for simple, bridge plate for comminuted; about 6 cortices each side
  • Plating advantages: lower reoperation, spares the shoulder, allows nerve exploration, best for the distal third
  • Nailing: load-sharing; antegrade (cuff and shoulder pain) or retrograde (distal blow-out risk)
  • Nailing is best for pathological, segmental, osteopenic and polytrauma fractures
  • Meta-analyses favour plating for shoulder function and lower reoperation; nailing has more shoulder problems

Complications

  • Radial nerve palsy about 12% (primary) β€” observe in a closed fracture; explore secondary, open or penetrating cases
  • Iatrogenic radial palsy with plating about 5 to 10% transient β€” protect the nerve at exposure
  • Nonunion: distal third, transverse pattern and distraction are high risk; the classic is the distal-third transverse
  • Antegrade-nail shoulder pain or impingement up to about 30%; correct entry, bury the nail, repair the cuff
  • Nonunion treatment of choice: compression plate plus autologous bone graft

Special cases

  • Pathological: stage and biopsy if the diagnosis is uncertain (exclude sarcoma); MDT before fixing
  • Pathological fixation: a nail (load-sharing, whole-bone) with or without cement plus post-op radiotherapy; goal is durable function
  • Impending fracture: use the Mirels score to decide on prophylactic fixation
  • Nonunion: revision compression plating plus iliac crest autograft; exclude infection first
  • No radial nerve recovery by 3 to 4 months: explore; if not reconstructable, tendon transfers (PT-ECRB, FCR or FCU-EDC, PL-EPL)

Background & Evidence


How humeral shaft fractures are described. The diaphysis is the segment between the proximal and distal metaphyses, and fractures are classified first by anatomic level (proximal, middle, or distal third) and by pattern (transverse, oblique, spiral, comminuted, or segmental). The AO/OTA alphanumeric system (a 12- prefix) is used principally for research and registry coding. Two patterns carry disproportionate exam weight because of their relationship to the radial nerve: the Holstein-Lewis distal-third spiral fracture (classically associated with radial nerve palsy as the nerve pierces the lateral intermuscular septum) and the distal-third transverse fracture (the classic nonunion pattern). The humerus is a non-weight-bearing bone surrounded by a generous soft-tissue sleeve, which is why functional bracing works so well and why substantial residual angulation is tolerated.

Transverse (mid or distal third)
Key features
At risk of distraction and nonunion
Fixation implication
Compress at plating; the classic nonunion pattern
Spiral distal third (Holstein-Lewis)
Key features
The distal fragment tents the radial nerve at the septum
Fixation implication
Classically associated with radial nerve palsy; explore if open or post-manipulation
Comminuted or segmental
Key features
Loss of cortical continuity
Fixation implication
Bridge plate (relative stability) or a load-sharing nail
Pathological or impending
Key features
A lytic or blastic lesion from low-energy trauma
Fixation implication
Stage and biopsy if the primary is unknown; prefer a nail
Open
Key features
The fracture communicates with the environment
Fixation implication
Debridement plus fixation; explore the nerve
Fracture pattern and level β€” fixation implications
Pattern or levelKey featuresFixation implication
Transverse (mid or distal third)At risk of distraction and nonunionCompress at plating; the classic nonunion pattern
Spiral distal third (Holstein-Lewis)The distal fragment tents the radial nerve at the septumClassically associated with radial nerve palsy; explore if open or post-manipulation
Comminuted or segmentalLoss of cortical continuityBridge plate (relative stability) or a load-sharing nail
Pathological or impendingA lytic or blastic lesion from low-energy traumaStage and biopsy if the primary is unknown; prefer a nail
OpenThe fracture communicates with the environmentDebridement plus fixation; explore the nerve

Key evidence. Sarmiento's large series established functional bracing as the standard non-operative treatment with high union rates and acceptable residual deformity, and the FISH randomised trial confirmed that bracing and plating give similar 12-month function in closed fractures (with a higher secondary-surgery rate for bracing). For radial nerve palsy, Shao's systematic review of over a thousand palsies found an overall prevalence of about 11.8 percent and no benefit to routine early exploration over expectant management for closed fractures. For the implant debate, the Heineman and Ouyang meta-analyses of randomised trials found fewer shoulder complications and lower reoperation with plating, and a higher rate of transient iatrogenic radial nerve palsy at open plating β€” so the device is matched to the fracture and patient. The An series showed that anterolateral MIPO with an extraperiosteal submuscular plate gives a high union rate with low radial nerve injury when the distal window is respected.

References


Evidence

Functional bracing for the treatment of fractures of the humeral diaphysis

Level IV
Sarmiento A, Zagorski JB, Zych GA, Latta LL, Capps CA β€’ J Bone Joint Surg Am (2000)
Key Findings:
  • Large series of 620 patients with humeral shaft fractures treated with functional bracing
  • Nonunion in only about 2 to 3% of closed fractures; the great majority united with good alignment
  • Residual angulation was generally within acceptable cosmetic and functional limits (commonly less than 16 degrees varus and less than 16 degrees anterior)
Clinical implication: Functional bracing is an effective default for most isolated closed humeral shaft fractures, with high union rates and acceptable residual deformity.
Verify on PubMed (PMID 10761938)
Evidence

Nonoperative compared with operative treatment of acute humeral diaphyseal fractures (FISH trial)

Level I
Ramo L, Sumrein BO, Lepola V, et al. β€’ JAMA (2020)
Key Findings:
  • Randomised trial comparing functional bracing with open reduction and plate fixation in closed humeral shaft fractures
  • No clinically important difference in DASH score at 12 months between operative and nonoperative groups
  • Bracing carried a higher nonunion and secondary-surgery rate; surgery carried procedure-specific risks including transient radial nerve palsy
Clinical implication: For closed isolated fractures, functional outcomes are similar at one year; bracing is a reasonable first line but a proportion require later surgery for nonunion.
Verify source (DOI)
Evidence

Radial nerve palsy associated with fractures of the shaft of the humerus: a systematic review

Level IV
Shao YC, Harwood P, Grotz MRW, Limb D, Giannoudis PV β€’ J Bone Joint Surg Br (2005)
Key Findings:
  • Systematic review of over 1000 radial nerve palsies associated with humeral shaft fractures
  • Overall radial nerve palsy prevalence about 11.8%; spontaneous recovery in around 70 to 90% of cases managed expectantly
  • No significant difference in final recovery between early exploration and expectant management for closed fractures
Clinical implication: Expectant management is appropriate for a primary radial nerve palsy in a closed fracture; exploration is reserved for open injuries, penetrating trauma, or palsy after manipulation.
Verify source (DOI)
Evidence

Plate fixation versus intramedullary nailing of humeral shaft fractures: meta-analysis

Level I
Heineman DJ, Bhandari M, Poolman RW β€’ Acta Orthop (2010)
Key Findings:
  • Meta-analysis of randomised controlled trials comparing dynamic compression plating with intramedullary nailing
  • Plating was associated with significantly fewer shoulder complications and lower reoperation rates
  • No significant difference in nonunion or infection between plate and nail in pooled data, but nailing trended to more shoulder problems
Clinical implication: In suitable diaphyseal fractures, plating better preserves shoulder function and reduces reoperation; nailing is reserved for indications where its biology and load-sharing are advantageous.
Verify source (DOI)
Evidence

Comparison of intramedullary nailing and plate fixation for humeral shaft fractures: meta-analysis of RCTs

Level I
Ouyang H, Xiong J, Xiang P, Cui Z, Chen L, Yu B β€’ J Shoulder Elbow Surg (2013)
Key Findings:
  • Meta-analysis of randomised controlled trials of nailing versus plating for humeral shaft fractures
  • Intramedullary nailing was associated with higher rates of shoulder impingement and restriction of shoulder motion
  • Plate fixation was associated with a higher rate of transient iatrogenic radial nerve palsy at the time of open exposure
Clinical implication: Technique choice trades shoulder morbidity (higher with antegrade nails) against the radial nerve handling and exposure of plating β€” match the device to the fracture and patient.
Verify source (DOI)
Evidence

Minimally invasive plate osteosynthesis (MIPO) for humeral shaft fractures

Level II
An Z, Zeng B, He X, Chen Q, Hu S β€’ Int Orthop (2010)
Key Findings:
  • Series of humeral shaft fractures treated with anterolateral MIPO using an extraperiosteal submuscular plate
  • High union rate with preservation of fracture-site biology and low radial nerve injury when the distal window is respected
  • Good shoulder and elbow function with minimal soft-tissue disruption
Clinical implication: MIPO offers plating's stability with a reduced biological insult and avoids shoulder violation; the distal window must respect the radial nerve as it crosses laterally.
Verify source (DOI)
Evidence

Fractures of the humerus with radial-nerve paralysis

Level V
Holstein A, Lewis GB β€’ J Bone Joint Surg Am (1963)
Key Findings:
  • The original description of the distal-third spiral fracture of the humeral shaft associated with radial nerve palsy
  • Explained the mechanism by which the nerve is injured as it pierces the lateral intermuscular septum
  • Established the eponymous pattern that still guides nerve-injury decision-making
Clinical implication: The Holstein-Lewis pattern is the classic association with radial nerve palsy; a palsy here is usually a recovering neuropraxia, but exploration is mandated for open, penetrating, or post-manipulation injuries.
Editorially reviewed β€” transparent references and correction processPublished by OrthoVellum Medical Education TeamEditorial boardMethodologyReview policy
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SURGICAL APPROACHES USED
Anterior Approach to Humeral Shaft (Henry)Posterior Approach to Humerus
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