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OPLL (Ossification of Posterior Longitudinal Ligament)

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OPLL (Ossification of Posterior Longitudinal Ligament)

Detailed guide to cervical OPLL, including K-Line classification and surgical decision making.

complete
Updated: 2026-01-02
High Yield Overview

OPLL (Ossification of Posterior Longitudinal Ligament)

Hyperostosis of the Ligament Causing Stenosis | Prevalence in East Asian Populations

2-4%Japanese Population
2:1Male:Female
50%Have DISH Association
20%Dural Tear Risk (Ant Surgery)

OPLL Classification (Tsuyama)

Continuous
PatternOssification extends over multiple vertebrae and discs
TreatmentHigh Risk
Segmental
PatternOssification behind vertebral bodies only (Discs spared)
TreatmentSafest for ACDF
Mixed
PatternCombination of Continuous and Segmental
TreatmentMost Common
Localized
PatternFocal ossification at intervertebral level
TreatmentRare

Critical Must-Knows

  • OPLL is a genetic disorder of heterotopic ossification (COL6A1, COL11A2 genes).
  • Strongly associated with DISH (Diffuse Idiopathic Skeletal Hyperostosis).
  • The 'Double Layer Sign' on CT suggests Dural Ossification (High risk of CSF leak).
  • The 'K-Line' (Kyphosis Line) determines if Posterior Surgery (Laminoplasty) is viable.
  • Major risk of surgery is C5 Palsy and Dural Tear.

Examiner's Pearls

  • "
    Always look for the 'Double Layer Sign' on CT before attempting Anterior Surgery.
  • "
    If K-Line is NEGATIVE (Ossification crosses line), Laminoplasty will FAIL (Need Fusion or Corpectomy).
  • "
    Beware of 'Floating Island' technique for dural adherence.
  • "
    Differential: AS (Ankylosing Spondylitis) - but AS affects discs/annulus, OPLL affects ligament.

Critical Surgical Decisions

At a Glance

Surgical Approach Selection

FactorAnterior (Corpectomy/ACDF)Posterior (Laminoplasty)Posterior (Laminectomy + Fusion)
K-Line StatusCan treat K-Line (-)Requires K-Line (+)Can treat K-Line (-) if corrected
Dural Tear RiskHigh (10-30%)Low (less than 1%)Low (less than 1%)
DecompressionDirect (Removes mass)Indirect (Drift back)Indirect + Realignment
C5 Palsy RiskLowModerateHigh

Mnemonics

Mnemonic

JAPANOPLL Associations

J
Japanese
Highest prevalence ethics group
A
Axial
Axial pain is minimal (unlike normal spondylosis)
P
Posterior
Posterior Longitudinal Ligament only
A
Age
Older onset (over 50)
N
Non-Insulin
Diabetes (NIDDM) is a strong risk factor

Memory Hook:Key demographic factors.

Mnemonic

SCMLTypes of OPLL

S
Segmental
Behind vertebral body only
C
Continuous
Spans multiple segments
M
Mixed
Both types
L
Localized
Single level (rare)

Memory Hook:Classification system.

Mnemonic

DOUBLECT Signs of Risk

D
Double
Double Layer Sign (Dural adherence)
O
Ossified
Ossified Dura
U
Unsafe
Unsafe to resect
B
Bleed
Bleeding (Epidural veins)
L
Leak
CSF Leak Risk
E
Eggshell
Leave eggshell bone (Floating Island)

Memory Hook:Surgical danger signs.

Overview and Epidemiology

Definition OPLL is a hyperostotic condition characterized by calcification and ossification of the posterior longitudinal ligament. It results in spinal canal stenosis and myelopathy.

Etiology

  • Genetic: Strong familial inheritance. Associated with collagen genes (COL11A2, COL6A1).
  • Metabolic: Associated with Diabetes (NIDDM), Obesity, and DISH.
  • Mechanical: Stress on the ligament may trigger osteogenesis.

Pathology

  • Begins as hypertrophy of the ligament.
  • Progresses to cartilaginous proliferation.
  • Ends in enchondral ossification.
  • Can penetrate the dura mater ("Dural Ossification"), making surgical separation impossible without dural resection.

Pathophysiology and Anatomy

The Posterior Longitudinal Ligament (PLL)

  • Runs along the posterior aspect of the vertebral bodies (within the canal).
  • Acts to prevent hyperflexion.
  • In OPLL, it becomes a space-occupying lesion anterior to the cord.

The K-Line (Kyphosis Line)

  • A virtual line drawn on a lateral Neutral X-ray.
  • Start: Midpoint of C2 Spinal Canal.
  • End: Midpoint of C7 Spinal Canal.
  • Significance: Defines the anterior limit of the spinal canal.
  • K-Line Positive: The OPLL mass lies ANTERIOR to the line. (Good for posterior surgery).
  • K-Line Negative: The OPLL mass CROSSES the line. (Posterior surgery will fail as cord cannot drift back past the mass).

Classification Systems

Tsuyama Classification (Based on Lateral X-ray/CT)

  1. Continuous Type (27%): A long lesion extending over several vertebrae. Most difficult to treat.
  2. Segmental Type (39%): Lesions located behind each vertebral body, not crossing the disc. (Safest for ACDF/Corpectomy as discs are clear).
  3. Mixed Type (29%): Combination of above. Most common.
  4. Localized Type (5%): Circumscribed lesion at disc level.

CT Signs of Dural Penetration

If present, anterior surgery has 100% risk of leak if resection attempted.

  1. Double Layer Sign: Anterior rim of ossification separated from posterior rim by a radiolucent line.
  2. C-Sign: Curved shape of the mass.

Clinical Assessment

Presentation

  • Similar to CSM but often more severe/rapid once symptomatic.
  • Myelopathy: Hands (clumsy), Gait (ataxic), Bladder (late).
  • Radiculopathy: Can occur if lateral extension involves roots.
  • Trauma: Acute quadriplegia after minor fall is a classic presentation (stiff spine + stenosis).

Examination

  • UMN signs (Hyperreflexia, Clonus, Hoffman's).
  • Limited ROM (Stiff neck - often has DISH).

DISH Co-morbidity

50% of OPLL patients have DISH. Check the rest of the spine (Thoracic/Lumbar) for ankylosis. Rigid spines are prone to "Chalk stick fractures".

Imaging and Investigations

Workup Protocol

CT ScanEssential
  • Mandatory for OPLL. MRI allows visualization but CT defines the bony anatomy.
  • Assess:
    • Thickness of ossification (greater than 50% canal occupancy = bad prognosis).
    • Shape (Beak/Hill/Mushroom).
    • Double Layer Sign (Dural involvement).
MRICord Status
  • T2 Signal: Check for myelomalacia.
  • Effacement: CSF signal loss.
X-RayDynamics
  • Lateral: Draw the K-Line. Measure C2-C7 angle.
  • Flex/Ext: Usually stiff, but check for instability.

Management Algorithm

📊 Management Algorithm
OPLL Management Algorithm
Click to expand
Strategic decision making for OPLL based on K-Line and Symptoms.
Clinical Algorithm— OPLL Management
Loading flowchart...

Non-Operative Management

Observation

  • Many patients have OPLL incidentally.
  • Progression rate is slow but steady.
  • Contraindications to observation: Progressive myelopathy (mJOA score dropping), acute onset.
  • Advice: Avoid contact sports, fall prevention, collar for comfort only.

Surgical Technique

Laminoplasty (Preferred)

  • Indication: Multilevel OPLL (C3-C7) with K-Line (+).
  • Rationale: Expanding the canal posteriorly allows the cord to "drift back" away from the anterior OPLL mass.
  • Technique: "Open Door" (Hirabayashi) or "French Door" (Kurokawa).
  • Plate Fixation: Use mini-plates to keep the lamina open.
  • Advantages: Preserves motion (vs fusion), lower complication rate than anterior.
  • Risks: C5 palsy (tethering from drift back), Axial neck pain.

Step-by-Step (Double Door / French Door):

  1. Positioning: Prone, Mayfield head clamp. Neck flexed slightly (military tuck).
  2. Exposure: Midline approach. Subperiosteal dissection to the lateral masses. Preserve the Semispinalis Cervicis attachment to C2 (reduces post-op kyphosis/pain).
  3. Spinous Process: Removed.
  4. Troughs:
    • Midline Trough: Created through the junction of the lamina (roof). Full thickness cut.
    • Lateral Troughs: Created at the lamina-facet junction bilaterally. Thin the outer cortex but leave the inner cortex intact (Greenstick fracture).
  5. Opening: The split lamina are opened like a book ("French Door") laterally.
  6. Fixation: Ceramic spacers or mini-plates bridge the gap and hold the door open.
  7. Closure: Deep closure over a drain.

Anterior Decompression (ACDF / Corpectomy)

  • Indication: K-Line (-) (Kyphosis), or massive focal compression greater than 60%.
  • Technique:
    • Radical Corpectomy of involved bodies.
    • Floating Island Method: If dura is ossified, DO NOT remove the last layer of OPLL. Thin it down with a diamond burr until it floats on the dura ("Floating Method"). This prevents CSF leak.
  • Risks:
    • CSF Leak: Very high (up to 30%).
    • Construct Failure: Long strut grafts kick out. Need posterior supplemental fixation often.

Step-by-Step (Corpectomy):

  1. Approach: Standard anterior Smith-Robinson. Extended to expose vertebral bodies.
  2. Discectomy: Performed at the levels above and below the OPLL.
  3. Corpectomy:
    • Leksell rongeurs remove the anterior vertebral body.
    • High speed burr creates a trough (15-20mm wide).
    • Lateral wall preserved to protect Vertebral Arteries.
  4. OPLL Resection:
    • The ossified ligament is thinned with a diamond burr.
    • It is carefully detached from the lateral dural margins with a micro-curette.
    • Floating: If adherent, the thinned island is left.
  5. Reconstruction:
    • Expandable cage or Fibula strut graft.
    • Anterior plating (locking screws).
    • If greater than 2 levels removed, add Posterior Instrumentation (360 fusion) to prevent graft kick-out.

Laminectomy + Fusion

  • Indication: K-Line (-) where Anterior surgery is too dangerous (dural ossification).
  • Technique: Wide laminectomy followed by instrumented fusion (Lateral mass / Pedicle screws).
  • Goal: Force correction of kyphosis into lordosis to create space.
  • Risks: High C5 palsy rate (aggressive shifting of cord).

Step-by-Step (Laminectomy + Fusion):

  1. Exposure: Midline posterior approach to C3-C7. Expose out to lateral masses.
  2. Instrumentation:
    • Lateral Mass Screws (C3-C6): Magerl or Roy-Camille technique. Start point 1mm medial to center of lateral mass. Drill 14mm, trajectory 25 deg lateral, 35 deg cephalad.
    • Pedicle Screws (C7/T1): Stronger fixation distally.
  3. Laminectomy:
    • High speed burr to create bilateral troughs at the lamina-facet junction.
    • En-bloc removal of the posterior arch (lamina and spinous processes).
    • Ensure the cord is free.
  4. Correction:
    • Rods are contoured into Lordosis.
    • Reduction and compression performed to restore cervical alignment.
    • This "pulls" the cord posteriorly away from the OPLL mass.
  5. Fusion: Decorticate lateral masses, place bone graft (autograft/allograft).

Complications

ComplicationAnt RatePost RateManagement
CSF LeakHigh (20%)LowLumbar drain, bed rest, fibrin glue. Do NOT repair primarily (tissue too thin).
C5 Palsy5%10-15%Observation. Usually recovers. Due to 'tethering' effect.
ProgressionLowMediumOPLL can grow post-surgery. Laminoplasty allows continued growth.
Implant FailureHigh (Corpectomy)LowUse supplemental posterior fixation for multilevel corpectomy.

Postoperative Care

  • CSF Leak Protocol: If leak suspected/confirmed: Flat bed rest 24-48hrs. Acetazolamide. Lumbar Drain if persistent.
  • Collar: Aspen collar 6 weeks (especially if fusion).
  • Neuro Rehab: Intensive gait training.

Outcomes and Prognosis

  • Surgical Outcome: Generally good if K-Line respected.
  • Recurrence: OPLL mass continues to grow in 20% of cases, especially with Laminoplasty (motion preserved). Fusion arrests growth.
  • Poor Prognostic Factors:
    • Diagnosis over 60 years.
    • Myelopathy duration over 1 year.
    • Massive canal occupancy (greater than 60%).
    • Trauma-induced onset.
    • High intramedullary signal intensity on T2 MRI.
    • Diabetes Mellitus (Poor wound healing, infection risk).

Progression Rates:

  • Longitudinal studies show OPLL grows 2mm/year in 10% of patients.
  • Anterior fusion stops this growth in the fused segments, but adjacent segment disease is accelerated.
  • Laminoplasty allows continued growth, but usually the canal expansion is sufficient to accommodate it.

Evidence Base

K-Line Classification

Fujiyoshi et al • Spine (2008)
Key Findings:
  • Introduced the concept of K-Line for deciding surgical approach.
  • K-Line (+) group had significantly better JOA recovery with Laminoplasty.
  • K-Line (-) group had POOR results with Laminoplasty (insufficient drift back).
  • Recommendation: K-Line (-) needs Anterior surgery or correcting fusion.
Clinical Implication: The K-Line is the single most important decision tool for OPLL.

Prospective Multicenter Study (Japan)

JSSR (Japanese Society) • J Ortho Sci (2015)
Key Findings:
  • 400+ patients with OPLL.
  • Anterior surgery had higher recovery rate (JOA) but higher complication rate.
  • Posterior surgery safer but slightly less recovery.
  • Dural tear rate in Anterior surgery: 15%.
Clinical Implication: Safety vs Efficacy trade-off. Start with Posterior if possible.

Surgical Complications of OPLL

Epstein • Surg Neurol (2012)
Key Findings:
  • Review of ossified dura management.
  • Floating Island technique significantly reduces CSF leak vs resection.
  • C5 palsy incidence up to 18% in posterior fusion groups.
Clinical Implication: Do NOT try to resect OPLL adherent to dura.

Genetics of OPLL

Karou et al • Am J Hum Genet (2013)
Key Findings:
  • Identified 6 susceptibility loci for OPLL.
  • Highlighted the role of COL6A1 and COL11A2.
  • Confirmed the strong genetic component independent of obesity/diabetes.
Clinical Implication: Genetic counselling may be relevant for families with severe disease.

Natural History of OPLL

Matsunaga et al • JBJS Br (1994)
Key Findings:
  • Followed 450 patients for over 10 years.
  • Patients with greater than 60% canal stenosis invariably developed myelopathy.
  • Trauma was the trigger in 20% of acute deteriorating cases.
  • Asymptomatic patients with less than 60% stenosis rarely progressed.
Clinical Implication: Prophylactic surgery only indicated for severe stenosis (greater than 60%) even if asymptomatic.

Viva Scenarios

Exam Viva Scenarios

Practice these scenarios to excel in your viva examination

VIVA SCENARIOStandard

Dural Ossification

EXAMINER

"You are performing an Anterior Corpectomy for OPLL. You reach the posterior cortex and drill it down. You see a white, hard layer that looks like dura but is bone. What is this and what do you do?"

EXCEPTIONAL ANSWER
This is likely **Dural Ossification**, indicated pre-operatively by the 'Double Layer Sign' or 'C-Sign'. **Action**: STOP drilling through it. **Technique**: Even thin islands of OPLL should be left floating on the dura (**Floating Method**). 1. Thin the ossified mass with a diamond burr until it is eggshell thin. 2. Detach it from the surrounding bone laterally. 3. Allow it to float forward with the dura (decompression) rather than resecting it. **Risk**: If I resect it, I will create a large dural defect which cannot be sewn (dura is calcified/absent). This leads to fistula, meningitis, and pseudomeningocele.
KEY POINTS TO SCORE
Recognize Dural Ossification pre-op (Double Layer Sign)
Floating Island Technique
Avoid resection of adherent bone
Manage CSF leak aggressively if it occurs
COMMON TRAPS
✗Trying to pick away the bone 'one last piece'
✗Ignoring the pre-op CT signs
VIVA SCENARIOStandard

K-Line Decision

EXAMINER

"60M with C3-C7 OPLL. Myelopathic. Lateral X-ray shows the OPLL mass crosses the K-Line. Lordosis is lost. Plan?"

EXCEPTIONAL ANSWER
This is a **K-Line Negative** case. **Reasoning**: - The mass is anterior to the K-Line essentially, but because of kyphosis/size, the cord is draped over it. - If I do a Laminoplasty (Posterior), the cord cannot drift back because the spine is straight/kyphotic and the mass is huge. The compression will remain. **Plan**: - **Option A (Anterior)**: Multilevel Anterior Decompression (Corpectomy/ACDF). *Pros*: Removes mass. *Cons*: High risk dural tear, implant failure. - **Option B (Posterior Fusion)**: Laminectomy + Instrumented Fusion. *Pros*: Safer for dura. *Cons*: Must use rods to force the neck into extension (correction) to pull the cord away. **My Choice**: Posterior Laminectomy and Fusion with correction, as anterior surgery for multilevel OPLL carries unacceptable dural tear risks in my hands.
KEY POINTS TO SCORE
Define K-Line (-)
Explain why Laminoplasty fails (No drift back)
Weigh risks of Anterior vs Posterior-Fusion
COMMON TRAPS
✗Offering Laminoplasty (It won't work)
✗Ignoring the alignment
VIVA SCENARIOStandard

Post-op Deterioration

EXAMINER

"Reviewing a post-op Laminoplasty patient on Day 1. He says he cannot lift his arms (Shoulders). Legs are fine."

EXCEPTIONAL ANSWER
This is a **C5 Palsy**. **Assessment**: - Check Deltoids (C5) and Biceps (C5/6). - Check sensation (Regimental badge). - Rule out Hematoma (Is there leg weakness? If legs fine, hematoma unlikely). **Mechanism**: Tethering of the C5 root as the cord drifts back. **Management**: - Reassurance (it usually recovers). - MRI to rule out hematoma/foraminal stenosis. - Physiotherapy to prevent frozen shoulder. - Recovery takes months.
KEY POINTS TO SCORE
Classic complication of Laminoplasty
Dissociated motor loss (Arms bad, Legs good)
Tethering mechanism
Good prognosis generally
COMMON TRAPS
✗Panicking and taking back to theatre without imaging
✗Missing a hematoma (check the legs!)

MCQ Practice Points

Genetics

Q: Which gene is most strongly associated with OPLL? A: COL6A1. (Collagen Type 6).

Association

Q: What is the most common concomitant spinal disorder in OPLL patients? A: DISH (Diffuse Idiopathic Skeletal Hyperostosis). Look for flowing osteophytes.

Imaging Sign

Q: Converting continuous OPLL to segmental type surgery has what sign on CT? A: Double Layer Sign. It indicates dural ossification.

Complication

Q: What is the most common neurological complication after posterior decompression for OPLL? A: C5 Palsy.

K-Line

Q: A 'Negative K-Line' implies what deformity? A: Kyphosis. The OPLL mass sits posterior to the line connecting C2 and C7 canal midpoints.

Australian Context

Incidence

  • While rare in Caucasians (0.1%), Australia has a significant Asian population where incidence approaches 2-3%.
  • Should be on the differential for any Asian patient presenting with myelopathy.

WorkCover

  • Often presents after minor trauma at work.
  • The pre-existing condition (OPLL) is the major cause, but the trauma is the "aggravating factor".

Exam Day Cheat Sheet

OPLL Summary

High-Yield Exam Summary

Key Concepts

  • •Ectopic Ossification (PLL)
  • •Japanese/Asian (greater than 2%)
  • •DISH Association
  • •Myelopathy over Radiculopathy

Classification

  • •Continuous vs Segmental
  • •K-Line (+) = Laminoplasty OK
  • •K-Line (-) = Anterior or Fusion
  • •Double Layer Sign = Dural Tear Risk

Surgery

  • •Posterior preferred (Safety)
  • •Anterior (Corpectomy) for K-Line (-)
  • •Floating Island Technique
  • •Instrumented Fusion for Correction

Risks

  • •C5 Palsy (Tethering)
  • •CSF Leak (Anterior)
  • •Progression (Recurrence)
  • •Pseudoarthrosis

Image Manifest

  • [opll-ct-sagittal-continuous.jpg]: CT sagittal showing continuous ossified strip behind bodies
    • [opll-mri-t2-cord-compression.jpg]: MRI showing cord compression by low signal mass
    • [opll-ct-axial-double-layer.jpg]: Axial CT showing double layer sign
Quick Stats
Reading Time56 min
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