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Jefferson Fracture

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Jefferson Fracture

Burst fracture of the C1 ring from axial loading - comprehensive guide covering biomechanics, classification, stability assessment, and management strategies for Orthopaedic examination

complete
Updated: 2024-12-16
High Yield Overview

JEFFERSON FRACTURE - C1 BURST INJURY

Axial Load | TAL Integrity Determines Stability | Rule of Spence Screening

6.9mmRule of Spence threshold
40-50%Associated C2 fractures
10%Neurological injury rate
8-12wkCollar duration if stable

TAL-BASED STABILITY CLASSIFICATION

Stable
PatternTAL intact (LMD under 6.9mm)
TreatmentRigid collar 8-12 weeks
Unstable
PatternTAL ruptured (LMD over 6.9mm)
TreatmentHalo vest or C1-C2 fusion
Dickman I
PatternMidsubstance TAL tear
TreatmentSurgery (cannot heal)
Dickman II
PatternBony avulsion
TreatmentMay heal with immobilization

Critical Must-Knows

  • Rule of Spence: Combined lateral mass displacement over 6.9mm suggests TAL rupture
  • MRI is gold standard for TAL integrity assessment - not just Rule of Spence
  • 40-50% have associated C2 fractures - always assess entire cervical spine
  • Steel's Rule of Thirds: Canal expansion explains low neurological injury rate
  • Midsubstance TAL rupture (Dickman I) cannot heal - requires surgical stabilization

Examiner's Pearls

  • "
    Jefferson expands the canal (low neuro injury) vs Hangman's translates (higher risk)
  • "
    ADI over 3mm in adults indicates atlantoaxial instability
  • "
    Goel-Harms technique is current gold standard for C1-C2 fusion
  • "
    Original 6.9mm threshold has magnification limitations - use clinical judgment

Critical Jefferson Fracture Exam Points

Rule of Spence

Combined LMD over 6.9mm suggests TAL rupture. But remember: original threshold based on cadaveric studies with magnification. Use as screening tool, not definitive diagnosis.

TAL Assessment

MRI is gold standard for TAL integrity. Dickman Type I (midsubstance) cannot heal = surgery. Type II (bony avulsion) may heal with immobilization.

Associated Injuries

40-50% have C2 fractures. Always CT entire cervical spine. Check for odontoid and Hangman's fractures. Consider CTA if transverse foramen involved.

Low Neuro Injury

Steel's Rule of Thirds: Canal expands with Jefferson fracture. Only 10% neurological injury rate. Compare to translation injuries which compress the canal.

Quick Decision Guide

Clinical ScenarioKey FindingStabilityTreatment
LMD under 6.9mm, MRI intact TALADI under 3mm, isolated C1StableRigid collar 8-12 weeks
LMD over 6.9mm, bony avulsionDickman Type II on MRIPotentially stableHalo vest 8-12 weeks (may heal)
LMD over 6.9mm, midsubstance tearDickman Type I on MRIUnstableC1-C2 fusion (Goel-Harms)
Associated C2 fractureCombined C1-C2 injuryVariableManage as worst injury dictates
Mnemonic

ATLAS

A
Axial load mechanism
vertex compression
T
Transverse ligament integrity
determines stability
L
Lateral mass displacement
measured on open-mouth view
A
ADI
atlanto-dental interval) on lateral radiograph
S
Six point nine
6.9mm) Rule of Spence threshold

Memory Hook:ATLAS helps you remember C1 (Atlas) fracture assessment - Axial load, TAL, Lateral mass, ADI, Six-nine rule

Mnemonic

BURST

B
Bilateral arch fractures
anterior and posterior
U
Understand TAL integrity
is key
R
Rule of Spence
for screening
S
Six point nine
mm combined displacement threshold
T
Treatment based on
stability

Memory Hook:BURST fracture assessment - Bilateral, Understand TAL, Rule of Spence, Six-nine, Treatment

Mnemonic

EXAMINE

E
Evaluate mechanism
axial load to vertex
X
X-ray initially, CT
definitive
A
Associated injuries
check C2, occipital condyles
M
Measure lateral mass
displacement
I
Integrity of TAL
MRI if unstable
N
Neurological examination
usually intact
E
Evaluate for vertebral
artery injury

Memory Hook:EXAMINE the Jefferson fracture patient systematically

Mnemonic

COLLAR

C
Check TAL integrity
with MRI
O
Open-mouth view for
lateral mass displacement
L
Less than 6.9mm
suggests stable
L
Look for associated
C2 fractures
A
ADI should be
less than 3mm
R
Rigid collar for
stable, surgery for unstable

Memory Hook:COLLAR reminds you of treatment for stable Jefferson fractures

Overview and Clinical Significance

The C1 Burst Fracture

Jefferson fracture, first described by Sir Geoffrey Jefferson in 1920, is a burst fracture of the atlas (C1) vertebra resulting from axial compression. The unique ring structure of C1, with its thin anterior and posterior arches, makes it susceptible to fracture when compressed between the skull and C2.

Epidemiology

2-13% of cervical spine fractures, 25% of C1 fractures, Peak age 20-40 years (trauma), Associated C2 fractures in 40-50%, Neurological injury rare (10%)

Mechanism

Axial load to vertex, Diving into shallow water, Fall onto top of head, Head-first motor vehicle accident, Objects falling onto head

Key Anatomy

C1 ring: anterior arch, posterior arch, Lateral masses articulate with C0 and C2, No vertebral body or disc, TAL connects lateral masses posteriorly, Dens held against anterior arch by TAL

Why Neurological Injury is Rare

The classic Jefferson fracture causes lateral displacement of the lateral masses, which actually increases the space available for the spinal cord. This is in contrast to translational injuries where the canal is compromised. The rule "Jefferson expands, Hangman's translates" helps explain the low neurological injury rate.

Exam Pearl

"Steel's Rule of Thirds": At C1 level, the spinal canal is divided into thirds - 1/3 dens, 1/3 cord, 1/3 space. A pure Jefferson fracture with lateral expansion increases the space available for the cord, explaining low neurological injury rates.

Differential Diagnosis and Associated Injuries

C1 Fracture Types

Not all C1 fractures are Jefferson fractures. Understanding the spectrum is important:

C1 Fracture Differential

Fracture TypeMechanismPatternStability
Jefferson (Burst)Axial loadBilateral anterior and posterior archDepends on TAL
Posterior Arch FractureExtensionIsolated posterior archStable
Anterior Arch FractureExtension with rotationIsolated anterior archUsually stable
Lateral Mass FractureAxial with lateral bendThrough lateral massUsually stable
Occipital Condyle FractureAxial or rotationAt craniocervical junctionVariable

Associated Cervical Injuries

Jefferson fractures commonly occur with other injuries - always evaluate the entire cervical spine:

Sagittal CT showing Jefferson fracture with associated odontoid (dens) fracture and posterior skull displacement
Click to expand
Sagittal CT demonstrating Jefferson fracture with associated Type II odontoid fracture and posterior displacement of skull - illustrating high rate (40-50%) of combined C1-C2 injuriesCredit: Gassend JL et al. Forensic Sci Med Pathol 2021. CC BY 4.0. PMC8119263

C2 Fractures (40-50%)

Odontoid fractures (Type II most common), Hangman's fractures (C2 pars), Combined C1-C2 instability, May alter management significantly, CT entire cervical spine mandatory

Occipital Condyle Fractures

Type I: Comminuted (stable), Type II: Basilar skull extension, Type III: Avulsion (unstable), CT skull base included, MRI for ligamentous injury

Vertebral Artery Injury

Risk with displaced fractures, Foramen transversarium involvement, CTA screening indicated, May be asymptomatic initially, Stroke risk if unrecognized

In polytrauma patients with Jefferson fracture, always assume there are associated injuries until proven otherwise. Complete cervical spine CT and thorough assessment of craniocervical junction are mandatory. Consider CTA if fractures involve the transverse foramen.

Pathophysiology and Mechanisms

C1 Vertebral Anatomy

The atlas is unique among cervical vertebrae:

C1 Structural Features

FeatureDescriptionClinical Relevance
Anterior archThin bone, articulates with dens via facetFractures under axial load at weakest point
Posterior archThin bone, vertebral artery grooveCommon fracture site, vertebral artery at risk
Lateral massesBear weight from skull, articulate C0 and C2Lateral displacement measured for stability
Transverse foramenContains vertebral arteryArtery injury possible with displaced fractures
No vertebral bodyRing structure onlyUnique biomechanics, no disc above or below
No spinous processPosterior tubercle onlyPalpation landmark (C1 not palpable)

Transverse Atlantal Ligament (TAL)

The TAL is the most important structure for C1-C2 stability:

TAL Anatomy

Strong band connecting lateral masses, Passes posterior to dens, Holds dens against anterior arch, Primary restraint to anterior translation, Part of cruciform ligament complex

TAL Function

Prevents C1 anterior translation, Allows rotation (C1 pivots around dens), Normal ADI less than 3mm adults, Rupture allows ADI increase, Intact TAL = stable injury

TAL Assessment

Rule of Spence on radiograph, ADI on lateral view, MRI gold standard, Direct visualization of ligament, Bone avulsion vs midsubstance tear

Biomechanics of Injury

When axial load is applied to the vertex:

  1. Force transmitted through occipital condyles to C1 lateral masses
  2. Wedge-shaped lateral masses forced apart
  3. C1 ring fractures at weakest points (anterior and posterior arches)
  4. Lateral masses displace outward
  5. TAL may rupture or avulse if displacement severe

Classification Systems

Levine-Edwards Classification

Based on fracture location within C1 ring:

Levine-Edwards C1 Fracture Classification

TypeDescriptionStabilityManagement
Type IPosterior arch fracture onlyStableCollar
Type IILateral mass fractureVariableAssess TAL
Type IIIAnterior arch fracture onlyStableCollar
Burst (Jefferson)Bilateral anterior and posterior arch fracturesDepends on TALAssess TAL integrity

Stability Classification

Based on TAL integrity (most clinically relevant):

Stable (TAL Intact)

Combined LMD less than 6.9mm, ADI less than 3mm, MRI shows intact TAL, Normal atlantoaxial relationship, Treatment: rigid collar

Unstable (TAL Incompetent)

Combined LMD greater than 6.9mm, ADI greater than 3mm (adults), MRI shows TAL rupture/avulsion, C1-C2 instability present, Treatment: halo or surgery

Dickman Classification of TAL Injuries

Dickman TAL Injury Classification

TypeDescriptionTreatmentPrognosis
Type IMidsubstance ruptureSurgery (cannot heal)Poor healing potential
Type IIBony avulsion from lateral massMay heal with immobilizationBetter healing potential

Exam Pearl

Dickman Type I (midsubstance TAL rupture) cannot heal and typically requires surgical stabilization. Type II (bony avulsion) may heal with rigid immobilization as bone-to-bone healing is possible.

Clinical Assessment

History

Key mechanism features:

  • Diving injury: Shallow water, head-first impact
  • Fall: Onto top of head (axial load)
  • MVA: Head-first collision, vertex impact
  • Falling object: Weight landing on head

Associated symptoms:

  • Neck pain (occipital, suboccipital)
  • Headache
  • Limited range of motion
  • Neurological symptoms (rare with isolated Jefferson)

Physical Examination

Maintain cervical spine immobilization until cleared. High association with other cervical fractures (40-50% have C2 injury). Complete ATLS primary survey before focused spine examination.

Examination findings:

  • Inspection: Cervical collar in place, head position
  • Palpation: Posterior midline tenderness (C1 not directly palpable)
  • Neurological: Full motor/sensory exam, cranial nerves
  • Vascular: Vertebral artery injury assessment if displaced fracture

Canadian C-Spine Rules Application

Jefferson fractures typically present with:

  • Dangerous mechanism (diving, fall from height)
  • Neck pain and tenderness
  • Unable to actively rotate neck 45 degrees
  • Therefore: imaging indicated

Investigations

Plain Radiographs

Open-Mouth (Odontoid) View:

  • Essential for measuring lateral mass displacement
  • Combined overhang of lateral masses measured
  • Compare C1 lateral mass edges to C2 lateral masses
  • Rule of Spence: greater than 6.9mm suggests TAL rupture

Lateral Cervical Radiograph:

  • Atlanto-dental interval (ADI)
  • Normal: less than 3mm in adults, less than 5mm in children
  • Prevertebral soft tissue swelling
  • C1-C2 alignment

CT Imaging

Gold standard for fracture delineation:

CT imaging demonstrating C1 anterior arch Jefferson fracture
Click to expand
Three-panel CT imaging of C1 anterior arch fracture. Panel a shows 3D reconstruction of cervical spine clearly demonstrating the fracture line. Panels b and c show axial CT slices through the C1 (atlas) ring revealing fracture of the anterior arch. This represents a Jefferson fracture pattern, though isolated to the anterior arch rather than the classic four-point burst pattern. The axial views are essential for assessing lateral mass displacement and ruling out associated posterior arch fractures.Credit: Hirano Y et al. via Surg Neurol Int via Open-i (NIH) (Open Access (CC BY))
Axial CT scan showing Jefferson fracture with fractures of both anterior and posterior arches of the atlas (C1)
Click to expand
Axial CT demonstrating classic Jefferson fracture pattern with fractures of both the anterior and posterior arches of C1Credit: Gassend JL et al. Forensic Sci Med Pathol 2021. CC BY 4.0. PMC8119263

CT Findings

Fracture pattern (bilateral arch fractures), Number and location of fractures, Lateral mass displacement (more accurate than radiograph), Associated fractures (C2, occipital condyles), Bone avulsion from TAL insertion

CT Limitations

Cannot directly visualize TAL, Ligamentous injury not assessed, Must correlate with clinical exam, May miss subtle instability, MRI needed for TAL assessment

MRI Assessment

Indications for MRI:

  • Combined LMD approaching or exceeding 6.9mm
  • ADI greater than 3mm
  • Any concern for ligamentous instability
  • Neurological deficit
  • Planning for definitive management

MRI TAL Assessment

FindingTAL StatusImplication
Intact low signal bandIntactStable injury, collar treatment
High signal within ligamentPartial injuryClose monitoring, consider halo
Discontinuous ligamentComplete rupture (Type I)Unstable, surgery likely
Bone fragment at lateral massAvulsion (Type II)May heal with immobilization

Rule of Spence - Detailed Application

Coronal CT and open-mouth radiograph showing lateral mass displacement measurement in Jefferson fracture
Click to expand
Lateral mass displacement (LMD) measurement: X-ray and coronal CT views demonstrating C1 lateral mass overhang beyond C2. Combined LMD over 6.9mm (Rule of Spence) suggests TAL incompetenceCredit: Tu Q et al. BMC Musculoskelet Disord 2021. CC BY 4.0. PMC8406960

Rule of Spence Limitations

The Rule of Spence (6.9mm) was derived from cadaveric studies using plain radiographs with inherent magnification. Modern CT measurements may be more accurate. Many centers use 7mm or consider any significant displacement as indication for MRI. The rule is a screening tool, not definitive for TAL rupture.

Measuring lateral mass displacement:

  1. On open-mouth or coronal CT
  2. Measure overhang of C1 lateral mass beyond C2 on each side
  3. Add both measurements = combined LMD
  4. Greater than 6.9mm (or 7mm): TAL likely incompetent
  5. Less than 6.9mm: does not exclude TAL injury, clinical correlation needed

Management Algorithm

📊 Management Algorithm
jefferson fracture management algorithm
Click to expand
Management algorithm for jefferson fractureCredit: OrthoVellum

Management Algorithm

Jefferson Fracture Identified
          │
          ▼
    Assess Stability
          │
    ┌─────┴─────┐
    │           │
    ▼           ▼
 Stable      Unstable
(TAL intact) (TAL ruptured)
    │           │
    ▼           ▼
  Collar     Halo vest
8-12 weeks   OR Surgery
    │           │
    ▼           ▼
 Flexion-    C1-C2 fusion
extension   (if halo fails
 at 12wk    or not tolerated)

Non-Operative Management

Indications:

  • Isolated Jefferson fracture with intact TAL
  • Combined LMD less than 6.9mm with MRI-confirmed intact TAL
  • Dickman Type II (bony avulsion) in select cases

Non-Operative Treatment Options

MethodDurationIndicationsConsiderations
Rigid cervical collar8-12 weeksStable fracture, TAL intactMost common, patient-friendly
Halo vest8-12 weeksUnstable pattern, TAL avulsionBetter immobilization, patient tolerance issues
Soft collarNot recommendedNone for acute fractureInsufficient immobilization

Surgical Management

Indications:

  • TAL midsubstance rupture (Dickman Type I)
  • Halo not tolerated or contraindicated
  • Associated unstable C2 fracture
  • Failed non-operative treatment
  • Persistent instability at follow-up

Surgical Options:

C1-C2 Fusion

Gallie, Brooks, or Magerl techniques, Eliminates C1-C2 rotation (50% of cervical rotation), High fusion rates, Accepted standard for unstable injury

Occipitocervical Fusion

If associated occipital condyle fracture, Basilar invagination present, Severely comminuted lateral masses, Greater loss of motion

C1 Lateral Mass Screws

Newer technique, May preserve motion if combined with TAL healing, Technically demanding, Not widely adopted

Special Considerations

Associated C2 Fractures (40-50%):

  • Must assess for odontoid fractures
  • Hangman's fracture common association
  • Combined injury may require more extensive fusion
  • Overall management dictated by most unstable injury

Pediatric Considerations: ADI up to 5mm may be normal. Synchondroses can mimic fractures. Higher proportion have TAL injuries. Consider MRI more liberally.

Surgical Techniques - C1-C2 Fusion

C1-C2 Fusion Techniques

TechniqueMethodAdvantagesDisadvantages
GalliePosterior wiring + sublaminar cable + graftSimple, familiarRequires supplemental halo, rotational instability
Brooks-JenkinsBilateral sublaminar cables + bone graftsBetter rotational control than GallieRisk to neural elements with cable passage
Magerl (Transarticular screws)C1-C2 transarticular screws + posterior fusionRigid fixation, high fusion rateVertebral artery at risk, technically demanding
Goel-HarmsC1 lateral mass + C2 pedicle screws + rodsAvoids vertebral artery with C2 screws, modularTechnically demanding, C2 nerve root at risk
Wright (C2 pars screws)C1 lateral mass + C2 pars interarticularis screwsAlternative to pedicle screwsShorter screw purchase

Goel-Harms Technique (Current gold standard):

  1. C1 lateral mass screws placed in inferior aspect of lateral mass
  2. C2 pedicle or pars screws with careful attention to vertebral artery
  3. Rods connected between C1 and C2 screws
  4. Posterior fusion with bone graft
  5. Allows intraoperative reduction if needed

Exam Pearl

The Goel-Harms technique has largely replaced traditional wiring techniques for C1-C2 fusion. It provides rigid segmental fixation without requiring supplemental halo immobilization and allows for intraoperative reduction of atlantoaxial subluxation.

Surgical Technique

Preoperative Planning

Imaging Review

CT with thin cuts through C1-C2, MRI to confirm TAL rupture, CTA to map vertebral artery course, Assess bone quality for screw placement, Plan trajectory to avoid vertebral artery

Patient Positioning

Supine with head in Mayfield pins, Gentle extension to open posterior space, Fluoroscopy available (AP and lateral), Neuromonitoring (SSEPs, MEPs), Ensure safe airway with cervical instability

Goel-Harms Technique (C1 Lateral Mass to C2 Pedicle Screws)

Post-operative MRI showing C1-C2 posterior fusion with polyaxial screw-rod construct
Click to expand
Two-panel sagittal MRI demonstrating successful C1-C2 posterior fusion using polyaxial screw-rod fixation. The construct employs lateral mass screws at C1 and pedicle screws at C2, connected by bilateral rods - the Goel-Harms technique. This represents definitive surgical treatment for unstable Jefferson fractures with TAL rupture (Dickman Type I midsubstance tears that cannot heal). Note the posterior approach preserves the anterior structures and achieves rigid atlantoaxial arthrodesis.Credit: Muthukumar N et al. via J Korean Neurosurg Soc via Open-i (NIH) (Open Access (CC BY))

Step 1: Exposure

  • Midline posterior incision C1-C2
  • Subperiosteal dissection exposing C1 posterior arch and C2 lamina/spinous process
  • Expose lateral masses of C1 bilaterally
  • Preserve C2 nerve roots (can be mobilized if needed)
  • Expose C1-C2 facet joints

Step 2: C1 Lateral Mass Screw Placement

  • Entry point: midpoint of posterior surface of C1 lateral mass
  • 10-15 degrees medial angulation to stay in lateral mass
  • 10 degrees cephalad angulation
  • Drill depth 18-20mm typically
  • Tap and place 3.5mm or 4.0mm polyaxial screw
  • Confirm position with fluoroscopy (lateral view shows screw anterior to posterior arch)

Vertebral Artery Danger: At C1, the vertebral artery passes superolateral to the lateral mass in the groove on the posterior arch. Stay within the lateral mass boundaries and use 10-15 degrees medial angulation to avoid lateral breach.

Step 3: C2 Pedicle Screw Placement

  • Entry point: 2-3mm cranial and 2-3mm lateral to medial border of C2 pars/facet junction
  • Trajectory: 20-25 degrees medial, 15-20 degrees cephalad
  • Palpate medial wall of pedicle with blunt probe
  • Drill depth 16-20mm into C2 body
  • Fluoroscopy confirms position (lateral: anterior cortex of C2 body, AP: medial to lateral mass)
  • Alternative: C2 pars screws (less medial angulation, shorter length)

Step 4: Rod Placement and Reduction

  • Contour rods to match lordotic curve
  • Place rods connecting C1 and C2 screw heads
  • Tighten set screws to lock rods in place
  • Can perform reduction maneuver if atlantoaxial subluxation present
  • Final tightening after confirming alignment

Step 5: Posterior Fusion

  • Decorticate posterior elements of C1 and C2
  • Apply morselized autograft (iliac crest) or allograft
  • Place between C1 posterior arch and C2 lamina
  • Consider local bone graft from spinous processes
  • Ensure good bone contact for fusion

Step 6: Closure

Irrigate copiously. Perform layered closure over drain. Apply rigid cervical collar postoperatively.

Alternative Techniques - Brief Overview

C1-C2 Fusion Technique Selection

ScenarioPreferred TechniqueRationale
Standard TAL ruptureGoel-HarmsRigid fixation, no halo needed, modular
Anomalous vertebral arteryModified technique with navigationAvoid vertebral artery injury
Poor C2 bone qualityOccipitocervical fusionExtend fixation for purchase
Posterior arch fracture preventing C1 screwsTransarticular or occipitocervicalCannot place C1 lateral mass screws

Exam Pearl

Goel-Harms technique offers advantages over traditional wiring (Gallie/Brooks) and transarticular screws (Magerl): it provides rigid segmental fixation without supplemental halo, allows intraoperative reduction, and avoids passing the vertebral artery with C2 screws when proper trajectory is used.

Complications

Jefferson Fracture Complications

ComplicationIncidenceRisk FactorsManagement
Non-union5-10%Severe displacement, inadequate immobilizationExtended immobilization or surgery
Chronic instabilityVariableMissed TAL injury, insufficient treatmentLate C1-C2 fusion
Vertebral artery injuryRareDisplaced fracture through foramenCTA screening, observation or intervention
Late C1-C2 arthritisUncommonMalunion, chronic instabilityUsually asymptomatic, fusion if symptomatic
Loss of rotationWith fusionC1-C2 fusion performedExpected, usually well-tolerated

Surgical Complications

Specific to C1-C2 fusion procedures:

Vertebral Artery Injury

2-4% risk with screw placement, Higher risk with C2 transarticular screws, Lower risk with Goel-Harms technique, Preoperative CTA essential, May require intraoperative vascular surgery

C5 Nerve Root Palsy

Shoulder abduction weakness, Typically transient, Mechanism unclear (traction vs cord shift), Physical therapy for recovery, Most recover by 6-12 months

Infection

1-3% deep wound infection, Higher risk in polytrauma, Prolonged antibiotics, May require hardware removal if chronic, Fusion can still occur

Hardware Failure

Screw loosening or breakage, Usually related to non-union, May require revision surgery, Prevention: ensure good bone quality, Augmentation options available

Vertebral artery injury during C1-C2 instrumentation can be catastrophic. Always obtain preoperative CTA to map vertebral artery anatomy. Consider navigation guidance for complex anatomy. Have vascular surgery backup available for high-risk cases.

Postoperative Care

Immediate Postoperative Management

First 24-48 Hours

ICU or step-down unit monitoring, Neurological checks every 2-4 hours, Maintain cervical collar (even after fusion), Drain management (remove at 24 hours), Early mobilization with PT/OT

Pain Management

Multimodal analgesia approach, Avoid NSAIDs first 6 weeks (fusion healing), Opioids as needed initially, Transition to non-opioid agents, Neuropathic pain medications if needed

DVT Prophylaxis

Sequential compression devices, Early mobilization, Chemical prophylaxis per trauma protocol, Balance bleeding risk with DVT risk, Continue until fully ambulatory

Immobilization Protocol

After C1-C2 Fusion:

  • Rigid cervical collar for 6-8 weeks
  • Collar provides additional support during fusion
  • Not primary immobilization (instrumentation provides stability)
  • Patient comfort and protection from inadvertent movement

After Collar Treatment (Stable Fracture):

  • Rigid collar for 8-12 weeks continuously
  • 24/7 wear except for bathing (with supervision)
  • Proper fit checked at each visit
  • Skin care to prevent breakdown
  • Compliance critical for healing

Follow-up Schedule

Follow-up Protocol by Treatment

Time PointNon-operative (Collar)Operative (Fusion)
2 weeksClinical exam, collar checkWound check, remove sutures, clinical exam
6 weeksRadiographs (AP/lateral), assess healingRadiographs, assess fusion, collar weaning
12 weeksCT to confirm union, flexion-extension XRCT to assess fusion, begin gentle ROM
6 monthsFinal stability check, return to activity clearanceConfirm solid fusion, full activity clearance
1 yearDischarge if stable and healedFinal fusion assessment, long-term follow-up

Rehabilitation Phases

Phase 1 (0-6 weeks): Immobilization

  • Maintain collar continuously
  • Avoid neck movement
  • Upper extremity ROM exercises
  • Gentle walking as tolerated
  • No lifting, bending, twisting

Phase 2 (6-12 weeks): Protected Mobilization

  • Continue collar if non-operative
  • Wean collar if operative and fusion progressing
  • Begin gentle isometric neck exercises
  • Gradual increase in daily activities
  • No contact sports or high-risk activities

Phase 3 (3-6 months): Active Rehabilitation

  • Full ROM exercises once stability confirmed
  • Strengthening program for neck/shoulder girdle
  • Proprioception training
  • Gradual return to work/sport
  • Supervised progression

Return to Activity Guidelines

Sedentary Work

Can work while in collar (non-operative), 2-4 weeks after surgery (operative), Ergonomic workstation setup, Frequent position changes, Avoid prolonged neck flexion

Driving

Not while in collar (neck rotation limited), After collar weaned and ROM restored, Must be able to check blind spots safely, Off narcotic pain medications, Typically 3-4 months post-injury

Contact Sports

Minimum 6 months post-injury, Confirmed solid fusion or healed fracture, Full ROM and strength restored, Individual risk assessment, Consider long-term risk with fusion (50% rotation loss)

Patients with C1-C2 fusion lose approximately 50% of cervical rotation. This has implications for driving, sports, and occupational activities. Counsel patients preoperatively about these functional limitations.

Complications to Monitor

During follow-up, watch for:

  • Non-union or malunion: Persistent pain, motion on flexion-extension
  • Hardware failure: Screw loosening or breakage (if operative)
  • Infection: Wound issues, fever, elevated inflammatory markers
  • C5 nerve root palsy: Shoulder weakness (rare but recognized complication)
  • Chronic pain: May require pain management referral
  • Adjacent segment degeneration: Long-term concern after fusion

Outcomes and Prognosis

Non-Operative Management Outcomes

Stable Jefferson Fractures (TAL Intact):

Union Rates

90-95% union with rigid collar, Healing typically complete by 12 weeks, Rare non-union if compliant with immobilization, Most achieve solid bony healing, Minimal long-term complications

Functional Outcomes

90-95% good to excellent outcomes, Return to full activity in most cases, Minimal residual neck pain, Preservation of full cervical ROM, High patient satisfaction

Return to Activity

Sedentary work: 2-4 weeks (in collar), Physical work: 3-6 months, Recreational sports: 3-6 months, Contact sports: 6-12 months (after confirmed healing), Driving: after collar removal and ROM restored

Surgical Management Outcomes

C1-C2 Fusion for Unstable Injuries:

Surgical Outcomes by Technique

TechniqueFusion RateFunctional OutcomeMotion Loss
Goel-Harms95-98%Excellent stability, good function50% cervical rotation
Transarticular screws90-95%High fusion rate, technically demanding50% cervical rotation
Wiring techniques80-90%Often requires supplemental halo50% cervical rotation
Occipitocervical95%+Very stable, greater motion lossAll C1-C2 rotation + flexion-extension

Long-Term Prognosis

Factors Predicting Good Outcome:

  • Early diagnosis and appropriate treatment
  • Isolated Jefferson fracture (no associated injuries)
  • Compliant with immobilization protocol
  • Young age and good bone quality
  • No neurological injury at presentation

Factors Predicting Poorer Outcome:

  • Associated C2 fractures or craniocervical injuries
  • Delayed diagnosis or treatment
  • Severe displacement requiring surgery
  • Polytrauma with multiple comorbidities
  • Pre-existing cervical pathology

Quality of Life After Treatment

After Collar Treatment

Most return to baseline function, No significant motion restriction, Can participate in all activities, Minimal impact on quality of life, Rare chronic pain

After C1-C2 Fusion

50% loss of cervical rotation, Most adapt well over 6-12 months, May need to turn whole body for blind spots, Can still participate in most activities, Generally high satisfaction (better than instability)

Natural History if Untreated

Understanding untreated Jefferson fractures:

  • Stable fractures: May heal with fibrous union, chronic instability possible
  • Unstable fractures: High risk of progressive C1-C2 instability
  • TAL rupture: Does not heal (Type I), progressive atlantoaxial subluxation
  • Chronic pain: Common with untreated instability
  • Late myelopathy: Rare but serious complication of chronic instability

Exam Pearl

The key to good outcomes in Jefferson fractures is accurate assessment of TAL integrity. Stable fractures do extremely well with collar treatment alone (greater than 90% good outcomes). Unstable fractures require appropriate immobilization or surgery but still achieve high fusion rates and functional outcomes.

Prognostic Scores and Predictors

While no specific prognostic scoring system exists for Jefferson fractures, general factors include:

  • Fracture displacement: More displacement = higher instability risk
  • TAL integrity: Intact TAL = excellent prognosis with collar
  • Associated injuries: Multiple injuries = more complex management
  • Patient age: Younger patients typically better outcomes
  • Comorbidities: Polytrauma impacts overall recovery

Evidence Base

Rule of Spence - Original Study

Level IV - Cadaveric Study
Spence KF et al. • J Bone Joint Surg Am (1970)
Key Findings:
  • Combined lateral mass displacement greater than 6.9mm associated with TAL rupture in cadaveric specimens. This threshold has been used clinically despite limitations of plain radiograph magnification.
Clinical Implication: Screening tool for TAL injury - patients exceeding threshold require MRI evaluation. Does not definitively diagnose TAL rupture.

MRI for TAL Assessment

Level IV - Case Series
Dickman CA et al. • Spine (1991)
Key Findings:
  • Classification of TAL injuries into Type I (midsubstance rupture) and Type II (bony avulsion). Type I injuries unlikely to heal and typically require surgical stabilization.
Clinical Implication: MRI is gold standard for TAL assessment. Type I injuries favor surgical management, Type II may be treated with immobilization.

Conservative Management Outcomes

Level IV - Retrospective
Kesterson L et al. • J Neurosurg (1991)
Key Findings:
  • High success rate (greater than 90%) with cervical collar immobilization for stable Jefferson fractures with intact TAL. Union typically achieved by 12 weeks.
Clinical Implication: Stable Jefferson fractures can be reliably treated with rigid cervical collar for 8-12 weeks with excellent outcomes.

Associated Cervical Injuries

Level III - Guidelines
Hadley MN et al. • Neurosurgery (2002)
Key Findings:
  • 40-50% of Jefferson fractures have associated C2 injuries (odontoid or Hangman's). Complete cervical spine imaging mandatory.
Clinical Implication: Always assess for C2 fractures. Combined injuries may alter management and prognosis.

Modern CT Measurement Standards

Level III - Retrospective
Radcliff K et al. • Spine (2012)
Key Findings:
  • CT-based measurements of lateral mass displacement may be more accurate than radiographs. Original 6.9mm threshold may need adjustment for CT measurements due to different magnification.
Clinical Implication: Consider that CT measurements may differ from original radiograph-based thresholds. Clinical correlation and MRI remain important.

Exam Viva Scenarios

Practice these scenarios to excel in your viva examination

VIVA SCENARIOStandard

Diving Injury with Jefferson Fracture

EXAMINER

"A 25-year-old male dove into shallow water and presents with neck pain. Radiographs show a Jefferson fracture with combined lateral mass displacement of 8mm. How would you manage this patient?"

EXCEPTIONAL ANSWER
I would manage this systematically. Initial assessment: ATLS protocol to rule out other injuries from the diving accident. Maintain cervical immobilization. Full neurological examination - likely intact with Jefferson fracture. Screen for associated injuries as 40-50% have C2 fractures. Imaging: CT cervical spine confirms fracture pattern and assesses C2. Combined LMD of 8mm exceeds the Rule of Spence threshold (6.9mm), so MRI is required to assess TAL integrity. Consider CTA if fracture involves transverse foramen. Management depends on MRI findings. If TAL intact: may treat with halo given significant displacement, or rigid collar with close follow-up. If TAL rupture (Dickman Type I): surgical stabilization with C1-C2 Goel-Harms fusion is required as midsubstance ligament ruptures cannot heal. If bony avulsion (Type II): halo vest 8-12 weeks may allow healing. Follow-up with flexion-extension radiographs to confirm stability.
KEY POINTS TO SCORE
Rule of Spence 6.9mm is screening tool - MRI is gold standard for TAL
Midsubstance TAL rupture cannot heal - requires surgery
Must exclude associated C2 fracture (40-50%)
Low neurological injury rate with pure Jefferson fracture
COMMON TRAPS
✗Treating without MRI to assess TAL
✗Missing associated C2 fractures
✗Using soft collar for unstable injury
✗Not recognizing Dickman Type I needs surgery
LIKELY FOLLOW-UPS
"What is the Goel-Harms technique?"
"How does Steel's Rule of Thirds explain low neuro injury rate?"
"What are the surgical complications of C1-C2 fusion?"
VIVA SCENARIOChallenging

Biomechanics of Jefferson Fracture

EXAMINER

"Explain the biomechanics of Jefferson fracture and why neurological injury is rare despite being an unstable upper cervical fracture."

EXCEPTIONAL ANSWER
This is an important biomechanical concept. Mechanism of injury: Axial load is applied to vertex of skull from diving or fall onto head. Force is transmitted through occipital condyles to C1 lateral masses. The wedge-shaped lateral masses are forced apart laterally. C1 ring fails at weakest points - anterior and posterior arches - resulting in bilateral arch fractures with lateral mass spreading. Why neurological injury is rare: Steel's Rule of Thirds is key. At C1, the canal is divided into 1/3 dens, 1/3 cord, 1/3 space. Jefferson fracture causes lateral expansion of the ring, which actually increases space available for the cord rather than compressing it. There is no translation or compression of the spinal canal. This contrasts with Hangman's fracture where C2 translates on C3 causing canal compromise. C1 is a ring vertebra with no vertebral body and has a large spinal canal diameter at the craniocervical junction. The fracture pattern tends to open rather than close the canal. Neurological injury occurs with associated C2 fracture with translation, combined craniocervical injury, severe associated trauma, or pre-existing canal stenosis.
KEY POINTS TO SCORE
Steel's Rule of Thirds: 1/3 dens, 1/3 cord, 1/3 space
Jefferson causes lateral expansion - increases canal space
No translation or compression of spinal canal
Contrast with Hangman's which compresses canal
COMMON TRAPS
✗Assuming unstable = high neuro injury risk
✗Not understanding Steel's Rule of Thirds
✗Confusing mechanism with Hangman's fracture
✗Forgetting C1 has no vertebral body
LIKELY FOLLOW-UPS
"What is the Rule of Spence?"
"How does TAL integrity affect stability?"
"What associated injuries occur with Jefferson fracture?"
VIVA SCENARIOStandard

Stable Jefferson Fracture Management

EXAMINER

"A 45-year-old female has a Jefferson fracture with lateral mass displacement of 5mm. MRI shows an intact TAL. How would you manage this, and what is your follow-up protocol?"

EXCEPTIONAL ANSWER
Assessment summary: Combined LMD of 5mm is below the Rule of Spence threshold. MRI confirms intact TAL - this is the key determinant. This is a STABLE Jefferson fracture. I would assess for associated injuries as 40-50% have C2 fractures. Treatment plan: Rigid cervical collar (Philadelphia, Miami J, or Aspen) for 8-12 weeks. No need for halo vest with confirmed intact TAL. Patient education on collar wear compliance is essential. Follow-up protocol: 2 weeks for clinical review and collar fit check. 6 weeks for repeat radiographs to assess healing. 12 weeks for CT scan to confirm union and flexion-extension radiographs to confirm stability. If stable at 12 weeks, wean collar and begin gentle ROM exercises. Return to activity: Sedentary work when comfortable in collar. Driving after collar weaned and full ROM restored. Contact sports minimum 3-6 months with confirmed healing and stability. Counsel on high-risk activities like diving. Red flags: increasing pain, new neurological symptoms, instability on flexion-extension views, or non-union at 12 weeks.
KEY POINTS TO SCORE
5mm LMD below Rule of Spence threshold
MRI intact TAL = stable injury
Rigid collar 8-12 weeks adequate
CT at 12 weeks to confirm union
COMMON TRAPS
✗Over-treating stable injury with halo or surgery
✗Not completing full 8-12 weeks immobilization
✗Missing associated C2 fractures
✗Allowing driving while in collar
LIKELY FOLLOW-UPS
"What imaging confirms union?"
"When can patient return to driving?"
"What if flexion-extension shows instability?"

MCQ Practice Points

Rule of Spence Threshold

Q: What is the Rule of Spence threshold for TAL incompetence in Jefferson fractures?

A: 6.9mm combined lateral mass displacement. This is the sum of overhang on both sides measured on open-mouth radiograph or coronal CT. Important caveat: this is a screening tool, not diagnostic. MRI is the gold standard for TAL integrity assessment. The original threshold came from cadaveric studies with radiographic magnification, so clinical judgment is essential.

Dickman Classification Decision

Q: A Jefferson fracture patient has MRI showing midsubstance TAL rupture. What is the treatment?

A: Surgical stabilization with C1-C2 fusion (Goel-Harms technique is current gold standard). This is Dickman Type I - midsubstance ruptures cannot heal as ligament-to-ligament healing is poor. In contrast, Dickman Type II (bony avulsion) may heal with halo immobilization as bone-to-bone healing is possible.

Associated C2 Fracture Rate

Q: What percentage of Jefferson fractures have associated C2 injuries?

A: 40-50%. This is why complete cervical spine CT is mandatory in all Jefferson fractures. Look specifically for odontoid fractures (Type II most common) and Hangman's fractures. Combined C1-C2 injuries may significantly alter management, with treatment dictated by the most unstable injury.

Steel's Rule of Thirds

Q: Why is neurological injury rare in isolated Jefferson fractures despite upper cervical instability?

A: Steel's Rule of Thirds explains the low neuro injury rate. At C1, the spinal canal is divided into thirds: 1/3 dens, 1/3 cord, 1/3 space. Jefferson fractures cause lateral expansion of the ring, which increases space available for the cord rather than compressing it. This contrasts with translation injuries (like Hangman's) which compress the canal. Only 10% neurological injury rate in pure Jefferson fractures.

C1-C2 Fusion Motion Loss

Q: What functional deficit occurs after C1-C2 fusion for unstable Jefferson fracture?

A: Loss of approximately 50% of cervical rotation. The atlantoaxial joint (C1-C2) accounts for half of total cervical rotation. This has important implications for driving (difficulty checking blind spots), sports, and occupational activities. Most patients adapt well over 6-12 months, but preoperative counseling is essential.

ADI Normal Values

Q: What is the normal atlanto-dental interval (ADI) in adults vs children?

A: Under 3mm in adults, under 5mm in children. Measured on lateral radiograph from the posterior cortex of the anterior C1 arch to the anterior cortex of the dens. ADI greater than 3mm in adults suggests TAL insufficiency and atlantoaxial instability. Children have physiologic ligamentous laxity accounting for the higher normal value.

Australian Context

Prehospital and Emergency Management in Australia

Jefferson fractures typically present in the context of major trauma, with patients requiring retrieval from injury sites and transport to specialized trauma centers. In Australia, spinal trauma management follows standardized protocols across state and territory trauma systems.

NSW Trauma Network provides guidelines for cervical spine immobilization during retrieval and transfer. Patients with suspected cervical spine injuries are transported in rigid cervical collars with head blocks, maintaining inline stabilization. Retrieval services include road ambulance, helicopter (CareFlight, Westpac Rescue Helicopter), and fixed-wing aircraft for remote areas. Early notification to receiving trauma centers allows for activation of spine surgery teams.

Victorian State Trauma System operates similarly, with major trauma services at Alfred Hospital, Royal Melbourne Hospital, and The Royal Children's Hospital providing tertiary spine surgery capabilities. Queensland's trauma system includes Royal Brisbane and Gold Coast University Hospital as major trauma centers with comprehensive spine surgery services.

Imaging Access and Diagnostic Pathways

CT scanning is readily available at all major Australian trauma centers, with immediate access for polytrauma patients. However, MRI access for TAL assessment can be challenging, particularly in regional and remote areas. Many regional hospitals lack 24/7 MRI availability, potentially requiring patient transfer to metropolitan centers for definitive assessment of TAL integrity.

Teleradiology services play an important role in rural spine trauma management. Regional centers can obtain expert opinion on CT imaging from metropolitan spine surgeons to guide initial management decisions. If MRI is essential for treatment planning (such as borderline Rule of Spence measurements), patient transfer may be necessary.

Specialist Spine Surgery Services

Australia has specialized spine surgery units concentrated in major metropolitan centers. These units provide 24/7 coverage for acute spinal trauma, including Jefferson fractures requiring surgical stabilization. The concentration of expertise means many patients require interfacility transfer from initial presentation sites to definitive management centers.

Spine surgery training in Australia follows the Orthopaedic Orthopaedic Surgery pathway, with many spine surgeons completing additional fellowships locally or internationally. The Australian Spine Society provides education and guidelines for spine trauma management.

Rehabilitation and Follow-up

Outpatient management of stable Jefferson fractures in rigid cervical collars is standard across Australia. Patients are reviewed regularly in outpatient fracture clinics, with follow-up imaging to confirm healing. Driving restrictions apply while patients are in cervical collars - they cannot legally drive due to restricted range of motion and inability to safely check blind spots.

Return to work assessment is important in the Australian medicolegal context. WorkCover schemes in each state provide coverage for workplace injuries, including compensation during recovery from Jefferson fractures. Occupational therapists assist with return-to-work planning, particularly for physically demanding occupations.

Medicare rebates cover follow-up imaging (radiographs and CT scans) for fracture assessment. Private health insurance may reduce waiting times for elective imaging where clinically appropriate.

Research and Quality Outcomes

Australian trauma registries collect data on spinal injuries including Jefferson fractures, contributing to national benchmarking of outcomes. The Australian and New Zealand Trauma Registry captures major trauma cases, allowing analysis of treatment patterns and outcomes across the trauma system.

Research from Australian spine units has contributed to understanding of Jefferson fracture management, including studies on imaging interpretation, treatment protocols, and long-term functional outcomes in the Australian population.

Exam Cheat Sheet

JEFFERSON FRACTURE

High-Yield Exam Summary

Key Anatomy

  • •C1 ring vertebra = no vertebral body
  • •TAL = primary restraint to anterior translation
  • •Steel's Rule of Thirds: 1/3 dens, 1/3 cord, 1/3 space
  • •Vertebral artery in transverse foramen at risk

Classification

  • •Stable = TAL intact (LMD under 6.9mm)
  • •Unstable = TAL ruptured (LMD over 6.9mm)
  • •Dickman I = midsubstance tear (surgery)
  • •Dickman II = bony avulsion (may heal)

Treatment Algorithm

  • •Stable (TAL intact): rigid collar 8-12 weeks
  • •Dickman II (avulsion): halo vest 8-12 weeks
  • •Dickman I (rupture): C1-C2 fusion (Goel-Harms)
  • •Associated C2: manage as worst injury dictates

Surgical Pearls

  • •Goel-Harms = current gold standard technique
  • •C1 lateral mass + C2 pedicle/pars screws
  • •Avoids vertebral artery with C2 screws
  • •Allows intraoperative reduction

Complications

  • •Non-union: 5-10% if inadequate immobilization
  • •Chronic instability: missed TAL injury
  • •Vertebral artery injury: rare but serious
  • •Loss of 50% cervical rotation with fusion
Quick Stats
Reading Time117 min
Related Topics

Hangman's Fracture

ACDF - Anterior Cervical Discectomy and Fusion

Adjacent Segment Disease

Adult Spinal Deformity