SCIATIC NERVE
The Largest Nerve in the Body
KEY CONCEPTS
Critical Must-Knows
- Strictly speaking, it is two nerves (Tibial + Common Peroneal) wrapped in one sheath
- Exits pelvis below the Piriformis muscle (in 85% of people)
- Supplies all hamstring muscles and all muscles below the knee
- Common Peroneal division is lateral and more vulnerable to stretch injury
- Injection Safe Zone: Upper Outer Quadrant of the buttock
Examiner's Pearls
- "The component to the Short Head of Biceps is the first branch of the Common Peroneal division
- "Sensory supply is entire foot/leg EXCEPT medial calf (Saphenous - Femoral)
- "Foot Drop is the classic sign of high Sciatic injury (Peroneal fibers are lateral)
- "Surgical approach: Posterior approach to hip puts it at risk (External Rotators protect it)
Clinical Imaging
Imaging Gallery


The Foot Drop Trap
High vs Low
Foot Drop is not always at the knee.
- A high Sciatic lesion often presents as an isolated Foot Drop because the Common Peroneal fibers are lateral and superficial.
- Differentiate: Check Hamstrings (Short Head Biceps) and Gluteals. If Glutes affected → Plexus/Root.
Injections
Upper Outer Quadrant.
- Any other quadrant risks the Sciatic (Lower Medial/Lateral) or Superior Gluteal (Upper Inner/Middle).
- In thin patients, the nerve is surprisingly superficial.
| Muscle | Component | Action | Innervation |
|---|---|---|---|
| Semimembranosus | Tibial | Knee Flex / Hip Ext | L5, S1, S2 |
| Semitendinosus | Tibial | Knee Flex / Hip Ext | L5, S1, S2 |
| Biceps (Long) | Tibial | Knee Flex / Hip Ext | S1, S2, S3 |
| Biceps (Short) | Com Peroneal | Knee Flexion | L5, S1, S2 |
| Adductor Mag | Tibial | Hip Extension | L4, L5, S1 |
P-I-N- P-I-N-SGreater Sciatic Foramen Contents
Memory Hook:PIN the PINS in the Foramen.
P-G-O-G-QDeep Rotators (Relations)
Memory Hook:Sciatic nerve lies ON these muscles (The Bed).
HAM-LEGSciatic Supply
Memory Hook:Sciatic supplies the HAM and the LEG (mostly).
Overview
The Sciatic Nerve is the largest nerve in the body, derived from the ventral rami of L4-S3. It serves as the primary conduit for motor and sensory signals to the lower limb. Its relations in the gluteal region are critical for arthroplasty surgery, and its division in the thigh dictates patterns of injury.
Neurovascular
Pelvic & Gluteal Course
- Origin: Sacral Plexus (Anterior surface of Piriformis).
- Exit: Leaves pelvis via Greater Sciatic Foramen, usually inferior to the Piriformis muscle.
- Gluteal Region: Descends deep to Gluteus Maximus, resting on the "Bed" of deep external rotators (Gemelli, Obturator Internus, Quadratus Femoris).
- Thigh: Enters posterior thigh deep to the Long Head of Biceps.
- Termination: Divides into Tibial and Common Peroneal nerves at the apex of the Popliteal Fossa (variable).
Structure
- The two components (Tibial and Common Peroneal) are physically separate within the epineurium from the origin.
- Medial: Tibial (Ventral divisions L4-S3).
Classification Systems
Beaton & Anson Classification
This classification describes the relationship between the Sciatic Nerve and the Piriformis muscle.
- Type A (85%): Undivided nerve passes below Piriformis.
- Type B (10%): Common Peroneal division passes through Piriformis; Tibial passes below.
- Type C (3%): Common Peroneal passes above Piriformis; Tibial below.
- Type D (less than 1%): Entire nerve passes through Piriformis.
- Type E (less than 1%): Entire nerve passes above Piriformis.
- Type F (less than 1%): Undivided nerve passes below, but there is an accessory piriformis.
Type B is the most clinically significant variant as it predisposes to Piriformis Syndrome (compression of the Common Peroneal division).
Surface Anatomy
Gluteal Region
- PSIS: Posterior Superior Iliac Spine.
- Ischial Tuberosity: Medial landmark (nerve is lateral).
- Greater Trochanter: Lateral landmark (nerve is medial).
The Sciatic Nerve emerges at the midpoint of a line connecting the Ischial Tuberosity to the Greater Trochanter.
Clinical Assessment
Straight Leg Raise
Lasègue's Sign.
- Passive elevation of leg with knee extended.
- Positive: Radicular pain (L5/S1) below knee at 30-70 degrees.
- Bragard's: Dorsiflexion increases pain.
- Sensitizing: Internal rotation stretches the nerve.
Reflexes
- Ankle Jerk (S1): Lost in Tibial/Sciatic lesions.
- Knee Jerk (L3/4): Preserved (Femoral nerve).
- Hamstring Reflex: Often diminished.
Differentiating High vs Low Lesion
| Muscle | High Sciatic | Common Peroneal (Knee) |
|---|---|---|
| Biceps Femoris (Short) | Weak/Paralyzed | Normal |
| Gluteus Max/Med | Normal (Plexus intact) | Normal |
| Tibialis Anterior | Weak | Weak |
| Hamstrings | Weak | Normal |
To confirm radicular origin:
- Flex the knee to relieve pain (Bowstring relaxed).
- Apply firm pressure in the popliteal fossa over the nerve.
- Positive: Pain returns (Confirming nerve tension/irritation).
Investigations
MRI
- MRI Lumbar Spine: Mandatory to rule out radiculopathy (disc herniation/stenosis) which is the most common cause of "Sciatica".
- MRI Pelvis: To assess the course of the nerve through the sciatic notch. Look for:
- Mass lesions (Hematoma, Tumor).
- Piriformis hypertrophy or asymmetry.
- Signal change (T2 hyperintensity) within the nerve indicative of neuritis or compression.
MR Neurography
- Specialized fluid-sensitive sequences to track the nerve fascicles.
- Highly sensitive for extraspinal sciatica.
This modality is particularly useful for identifying non-compressive etiologies like neuritis.
Clinical Relevance
Sciatica and Palsy
| Condition | Management | Indication for Surgery |
|---|---|---|
| Acute Sciatica (Disc) | NSAIDS, Physio, Time | Cauda Equina / Motor Deficit |
| Hip Dislocation | Reduction, splint in ext | Nerve entrapment in joint |
| Piriformis Syn | Stretch, Injection | Failure of conservative |
| Injection Palsy | Observe, EMG | Pain/No recovery over 3m |
- Reduction: In hip dislocation, prompt reduction is the primary treatment for the nerve (ischemia).
- Neurolysis: Indicated for tethering or persistent compression (e.g., scarring after trauma).
Neurolysis should be performed with magnification to avoid disrupting the epineural blood supply.
Injection Injury Protocol
- Immediate: Stop injection. Document drug and volume.
- Acute Phase: Analgesia (Neuropathic agents). MRI to look for hematoma (compressive).
- Chronic Phase: Serial EMG. If no recovery at 3-6 months, consider exploration and neurolysis (poor prognosis if intrafascicular injection occurred).
Surgical Technique
Posterior Exposure (Thigh)
- Incision: Midline posterior thigh.
- Deep Flexia: Split Gluteus Maximus proximally.
- Identification: Find nerve deep to Long Head of Biceps (guides you to it).
- Neurolysis: Release adhesions from hamstring origin or quadratus femoris.
Always identify the nerve in normal tissue (distally or proximally) before dissecting the scarred zone.
Complications
- Foot Drop: Most common manifestation of injury. Requires AFO (Ankle Foot Orthosis).
- Neuropathic Pain: Often severe (Type II CRPS).
- Pressure Sores: Insensate foot/heel.
- Contracture: Equinus deformity if not splinted.
Rehabilitation Protocol
- Splinting: Anti-drop foot splint (AFO) immediately.
- ROM: Passive ankle dorsiflexion to prevent contracture.
- Strengthening: Hamstrings and Glutes.
- Nerve Glides: Sciatic sliders flossing techniques.
- Return to Sport: Dependent on motor recovery (Variable).
Prognosis
- Stretch Injury: Good prognosis (neuropraxia).
- Injection Injury: Poor prognosis (chemical neurolysis).
- Laceration: Guarded. Rate of regeneration is 1mm/day, but the distance to the foot is distinctively long (causes motor endplate death before nerve arrives).
- Common Peroneal: Paradoxically worse prognosis than Tibial division (less vascular, more tethered).
Evidence Base
Sciatic Nerve recovery after Hip Dislocation
- 10-15% incidence of palsy in posterior dislocation
- Partial recovery in 60-70% of cases
- Common Peroneal division recovers less often than Tibial
- Iatrogenic traction palsy has better prognosis than contusion
Piriformis Syndrome Diagnosis
- MR Neurography shows high signal in nerve at sciatic notch
- Positive response to Botox injection helps confirm diagnosis
- Surgery effective in 80% of properly selected cases
Injection Palsy Outcomes
- Intrafascicular injection causes direct chemical neurotoxicity
- Pain is the primary warning sign - procedure must be abandoned
- Surgical exploration within hours does NOT improve outcome
- Conservative management yields poor results for severe deficits
Sciatic Nerve Division Patterns
- Tibial and common peroneal divisions distinct within gluteal region in 88%
- High division (at piriformis) in 12%
- Tibial component located medially and posteriorly
- Common peroneal more vulnerable due to superficial lateral position
Sciatic Nerve Palsy After THA
- Incidence 0.5-2% after primary THA
- Up to 6% in revision surgery and dysplasia
- Limb lengthening over 4cm is major risk factor
- Peroneal division affected in 70% of palsies
- Full recovery in only 40% of cases
Viva Scenarios
Practice these scenarios to excel in your viva examination
Scenario 1: Post-THR Foot Drop
"You perform a posterior approach THR. In recovery, the patient has a foot drop. Take me through your management."
Scenario 2: The Gluteal Injection
"A nurse calls you. A patient complained of immediate burning pain down the leg during an IM injection. What do you do?"
Scenario 3: Piriformis Syndrome
"A cyclist complains of deep buttock pain and sciatica. MRI spine is normal. How do you assess for Piriformis Syndrome?"
MCQ Practice Points
Safe Zone
Q: Where is the safe zone for intragluteal injection? A: Upper Outer Quadrant. This avoids the Sciatic Nerve (Lower Medial/Lateral) and Superior Gluteal Nerve (Upper Medial).
Common Peroneal Vulnerability
Q: Why is the Common Peroneal division more susceptible to injury? A: It is lateral, more superficial, and has fewer fascicles with less connective tissue. It is also tethered at the fibular head, reducing its ability to glide during stretch.
Hamstring Innervation
Q: Which hamstring muscle is NOT supplied by the Tibial division? A: Short Head of Biceps Femoris. It is supplied by the Common Peroneal division. This is a key differentiator for high vs low lesions.
Adductor Magnus
Q: What is the innervation of the 'Hamstring portion' of Adductor Magnus? A: Tibial Division of Sciatic Nerve. The adductor portion is supplied by the Obturator Nerve.
Root Value
Q: What are the root values of the Sciatic Nerve? A: L4, L5, S1, S2, S3. It is the largest branch of the sacral plexus.
Australian Context
- Trauma: Motor vehicle accidents (Posterior Hip Dislocation) are a major cause.
- Arthroplasty: Australia has a high volume of hip replacements; sciatic palsy is a medicolegal risk. Documentation of pre-op status is mandatory.
- Guidelines: The AOA guidelines suggest careful retractor placement and awareness of limb lengthening.
High-Yield Exam Summary
Anatomy
- •Roots: L4-S3
- •Exit: Greater Sciatic Foramen
- •Relation: Inf to Piriformis
- •Divisions: Tibial (Med), CP (Lat)
Clinical
- •Sign: SLR (Lasègue)
- •Motor: Hamstrings + All below knee
- •Reflex: Ankle (S1), Hamstring
- •Safe Zone: Upper Outer Quadrant
Pathology
- •Hip Dislocation: 10% Palsy
- •THR: Traction/Retractor injury
- •Injection: Chemical neuritis
- •Piriformis: Compression