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Sciatic Nerve Anatomy

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Sciatic Nerve Anatomy

Comprehensive guide to the anatomy, clinical assessment, and management of the Sciatic Nerve, including Piriformis relations and injection safety

complete
Updated: 2025-12-20
High Yield Overview

SCIATIC NERVE

The Largest Nerve in the Body

L4-S3Roots
2 cmWidth
Com PerDivision 1
TibialDivision 2

KEY CONCEPTS

Anatomy
PatternLeaves pelvis via Greater Sciatic Foramen
TreatmentInf to Piriformis
Variant
PatternBeaton & Anson Types
TreatmentPeroneal Through Muscle
Risk
PatternPosterior Hip Dislocation
Treatment10% Palsy Rate
Sign
PatternStraight Leg Raise (Lasègue)
TreatmentL5/S1 Tension

Critical Must-Knows

  • Strictly speaking, it is two nerves (Tibial + Common Peroneal) wrapped in one sheath
  • Exits pelvis below the Piriformis muscle (in 85% of people)
  • Supplies all hamstring muscles and all muscles below the knee
  • Common Peroneal division is lateral and more vulnerable to stretch injury
  • Injection Safe Zone: Upper Outer Quadrant of the buttock

Examiner's Pearls

  • "
    The component to the Short Head of Biceps is the first branch of the Common Peroneal division
  • "
    Sensory supply is entire foot/leg EXCEPT medial calf (Saphenous - Femoral)
  • "
    Foot Drop is the classic sign of high Sciatic injury (Peroneal fibers are lateral)
  • "
    Surgical approach: Posterior approach to hip puts it at risk (External Rotators protect it)

Clinical Imaging

Imaging Gallery

Extensive tear of the left hamstring muscle origin with sciatic nerve scarring in a 54-year-old patient after a water skiing injury. Axial T1-weighted images (a) and (b) identify a tear of left hamstr
Click to expand
Extensive tear of the left hamstring muscle origin with sciatic nerve scarring in a 54-year-old patient after a water skiing injury. Axial T1-weightedCredit: Dong Q et al. via Radiol Res Pract via Open-i (NIH) (Open Access (CC BY))
Surgically proven neurofibroma of the left sciatic nerve in a 33-year-old patient. Axial T2-weighted fat-saturated (a) and sagittal T1-weighted postcontrast (b) images show a lobulated enhancing mass
Click to expand
Surgically proven neurofibroma of the left sciatic nerve in a 33-year-old patient. Axial T2-weighted fat-saturated (a) and sagittal T1-weighted postcoCredit: Dong Q et al. via Radiol Res Pract via Open-i (NIH) (Open Access (CC BY))

The Foot Drop Trap

High vs Low

Foot Drop is not always at the knee.

  • A high Sciatic lesion often presents as an isolated Foot Drop because the Common Peroneal fibers are lateral and superficial.
  • Differentiate: Check Hamstrings (Short Head Biceps) and Gluteals. If Glutes affected → Plexus/Root.

Injections

Upper Outer Quadrant.

  • Any other quadrant risks the Sciatic (Lower Medial/Lateral) or Superior Gluteal (Upper Inner/Middle).
  • In thin patients, the nerve is surprisingly superficial.
MuscleComponentActionInnervation
SemimembranosusTibialKnee Flex / Hip ExtL5, S1, S2
SemitendinosusTibialKnee Flex / Hip ExtL5, S1, S2
Biceps (Long)TibialKnee Flex / Hip ExtS1, S2, S3
Biceps (Short)Com PeronealKnee FlexionL5, S1, S2
Adductor MagTibialHip ExtensionL4, L5, S1
Mnemonic

P-I-N- P-I-N-SGreater Sciatic Foramen Contents

P
Piriformis
The Key Muscle
I
Inferior
Gluteal Nerve/Vessels
N
Nerve
to Obturator Internus
P
Pudendal
Nerve
I
Internal
Pudendal Vessels
N
Nerve
to Quadratus Femoris
S
Sciatic
Nerve & PCN of Thigh

Memory Hook:PIN the PINS in the Foramen.

Mnemonic

P-G-O-G-QDeep Rotators (Relations)

P
Piriformis
The Roof
G
Gemellus
Superior
O
Obturator
Internus
G
Gemellus
Inferior
Q
Quadratus
Femoris (The Bed)

Memory Hook:Sciatic nerve lies ON these muscles (The Bed).

Mnemonic

HAM-LEGSciatic Supply

H
Hamstrings
All posterior thigh
A
Adductor
Magnus (Hamstring part)
M
Muscles
All below knee
L
Leg
Sensory to Leg/Foot
E
Excluding
Saphenous (Medial Calf)
G
Glutes
NOT Supplied (Plexus)

Memory Hook:Sciatic supplies the HAM and the LEG (mostly).

Overview

The Sciatic Nerve is the largest nerve in the body, derived from the ventral rami of L4-S3. It serves as the primary conduit for motor and sensory signals to the lower limb. Its relations in the gluteal region are critical for arthroplasty surgery, and its division in the thigh dictates patterns of injury.

Neurovascular

Pelvic & Gluteal Course

  • Origin: Sacral Plexus (Anterior surface of Piriformis).
  • Exit: Leaves pelvis via Greater Sciatic Foramen, usually inferior to the Piriformis muscle.
  • Gluteal Region: Descends deep to Gluteus Maximus, resting on the "Bed" of deep external rotators (Gemelli, Obturator Internus, Quadratus Femoris).
  • Thigh: Enters posterior thigh deep to the Long Head of Biceps.
  • Termination: Divides into Tibial and Common Peroneal nerves at the apex of the Popliteal Fossa (variable).

Structure

  • The two components (Tibial and Common Peroneal) are physically separate within the epineurium from the origin.
  • Medial: Tibial (Ventral divisions L4-S3).

Critical Relations

  • Anterior (Deep): Ischium, Gemelli, Obturator Internus, Quadratus Femoris, Adductor Magnus.
  • Posterior (Superficial): Piriformis, Gluteus Maximus, Long Head of Biceps.
  • Medial: Inferior Gluteal Artery/Nerve.
  • Lateral: Greater Trochanter.

In the posterior approach to the hip, the nerve is identified and protected. The External Rotators are detached to expose the joint, protecting the nerve behind them.

Variation Overview

The anatomical relationship between the Sciatic Nerve and the Piriformis muscle is highly variable. The standard anatomy (nerve improper passing inferior to muscle) is present in 85% of cases.

Other key variations include high divisions, where the Tibial and Common Peroneal nerves exit the pelvis separately.

Classification Systems

Beaton & Anson Classification

This classification describes the relationship between the Sciatic Nerve and the Piriformis muscle.

  • Type A (85%): Undivided nerve passes below Piriformis.
  • Type B (10%): Common Peroneal division passes through Piriformis; Tibial passes below.
  • Type C (3%): Common Peroneal passes above Piriformis; Tibial below.
  • Type D (less than 1%): Entire nerve passes through Piriformis.
  • Type E (less than 1%): Entire nerve passes above Piriformis.
  • Type F (less than 1%): Undivided nerve passes below, but there is an accessory piriformis.

Type B is the most clinically significant variant as it predisposes to Piriformis Syndrome (compression of the Common Peroneal division).

Surface Anatomy

Gluteal Region

  • PSIS: Posterior Superior Iliac Spine.
  • Ischial Tuberosity: Medial landmark (nerve is lateral).
  • Greater Trochanter: Lateral landmark (nerve is medial).

The Sciatic Nerve emerges at the midpoint of a line connecting the Ischial Tuberosity to the Greater Trochanter.

Posterior Thigh

  • The nerve runs vertically down the midline of the thigh.
  • It is covered by the Long Head of Biceps Femoris.
  • Surface Marking: Join the midpoint between Ischial Tuberosity/Greater Trochanter to the apex of the Popliteal Fossa.
  • Palpation: Difficult due to muscle bulk, but can be tender in the sciatic notch (midway between PSIS and Greater Trochanter).

Palpation is rarely diagnostic.

Clinical Assessment

Straight Leg Raise

Lasègue's Sign.

  • Passive elevation of leg with knee extended.
  • Positive: Radicular pain (L5/S1) below knee at 30-70 degrees.
  • Bragard's: Dorsiflexion increases pain.
  • Sensitizing: Internal rotation stretches the nerve.

Reflexes

  • Ankle Jerk (S1): Lost in Tibial/Sciatic lesions.
  • Knee Jerk (L3/4): Preserved (Femoral nerve).
  • Hamstring Reflex: Often diminished.

Differentiating High vs Low Lesion

MuscleHigh SciaticCommon Peroneal (Knee)
Biceps Femoris (Short)Weak/ParalyzedNormal
Gluteus Max/MedNormal (Plexus intact)Normal
Tibialis AnteriorWeakWeak
HamstringsWeakNormal
The Bowstring Sign

To confirm radicular origin:

  • Flex the knee to relieve pain (Bowstring relaxed).
  • Apply firm pressure in the popliteal fossa over the nerve.
  • Positive: Pain returns (Confirming nerve tension/irritation).

Investigations

MRI

  • MRI Lumbar Spine: Mandatory to rule out radiculopathy (disc herniation/stenosis) which is the most common cause of "Sciatica".
  • MRI Pelvis: To assess the course of the nerve through the sciatic notch. Look for:
    • Mass lesions (Hematoma, Tumor).
    • Piriformis hypertrophy or asymmetry.
    • Signal change (T2 hyperintensity) within the nerve indicative of neuritis or compression.

MR Neurography

  • Specialized fluid-sensitive sequences to track the nerve fascicles.
  • Highly sensitive for extraspinal sciatica.

This modality is particularly useful for identifying non-compressive etiologies like neuritis.

EMG / NCS

  • Differentiate: Plexus vs Root vs Peripheral Nerve.
  • H-Reflex: Prolonged latency indicates S1 radiculopathy (or sciatic).
  • F-Wave: Assess proximal conduction.
  • Needle EMG:
    • Gluteal sparing: Indicates lesion is distal to the plexus (Sciatic).
    • Short Head Biceps involvement: Indicates lesion is high (thigh/pelvis) rather than at the knee.
    • Paraspinal involvement: Indicates Root level lesion.

NCS shows slowed conduction velocity across the segment of compression (if demyelinating) or reduced amplitude (if axonal loss).

Clinical Relevance

Sciatica and Palsy

ConditionManagementIndication for Surgery
Acute Sciatica (Disc)NSAIDS, Physio, TimeCauda Equina / Motor Deficit
Hip DislocationReduction, splint in extNerve entrapment in joint
Piriformis SynStretch, InjectionFailure of conservative
Injection PalsyObserve, EMGPain/No recovery over 3m
  • Reduction: In hip dislocation, prompt reduction is the primary treatment for the nerve (ischemia).
  • Neurolysis: Indicated for tethering or persistent compression (e.g., scarring after trauma).

Neurolysis should be performed with magnification to avoid disrupting the epineural blood supply.

Injection Injury Protocol

  1. Immediate: Stop injection. Document drug and volume.
  2. Acute Phase: Analgesia (Neuropathic agents). MRI to look for hematoma (compressive).
  3. Chronic Phase: Serial EMG. If no recovery at 3-6 months, consider exploration and neurolysis (poor prognosis if intrafascicular injection occurred).

Surgical Technique

Posterior Exposure (Thigh)

  • Incision: Midline posterior thigh.
  • Deep Flexia: Split Gluteus Maximus proximally.
  • Identification: Find nerve deep to Long Head of Biceps (guides you to it).
  • Neurolysis: Release adhesions from hamstring origin or quadratus femoris.

Always identify the nerve in normal tissue (distally or proximally) before dissecting the scarred zone.

Protection in Hip Arthroplasty (Posterior Approach)

  • Identify nerve before placing retractors.
  • Pearl: Keep the hip extended and knee flexed to relax the nerve.
  • Retractor: Place retractors on the bone (acetabular rim), NOT in soft tissue where the nerve lies.
  • Palpate nerve tension during reduction.

The "safe zone" for retractor placement or screws is the posterosuperior quadrant of the acetabulum (away from the nerve).

Complications

  • Foot Drop: Most common manifestation of injury. Requires AFO (Ankle Foot Orthosis).
  • Neuropathic Pain: Often severe (Type II CRPS).
  • Pressure Sores: Insensate foot/heel.
  • Contracture: Equinus deformity if not splinted.

Rehabilitation Protocol

  • Splinting: Anti-drop foot splint (AFO) immediately.
  • ROM: Passive ankle dorsiflexion to prevent contracture.
  • Strengthening: Hamstrings and Glutes.
  • Nerve Glides: Sciatic sliders flossing techniques.
  • Return to Sport: Dependent on motor recovery (Variable).

Prognosis

  • Stretch Injury: Good prognosis (neuropraxia).
  • Injection Injury: Poor prognosis (chemical neurolysis).
  • Laceration: Guarded. Rate of regeneration is 1mm/day, but the distance to the foot is distinctively long (causes motor endplate death before nerve arrives).
  • Common Peroneal: Paradoxically worse prognosis than Tibial division (less vascular, more tethered).

Evidence Base

Sciatic Nerve recovery after Hip Dislocation

3
Cornwall et al. • J Orthop Trauma (2000)
Key Findings:
  • 10-15% incidence of palsy in posterior dislocation
  • Partial recovery in 60-70% of cases
  • Common Peroneal division recovers less often than Tibial
  • Iatrogenic traction palsy has better prognosis than contusion
Clinical Implication: Counsel patients on the likelihood of permanent foot drop.

Piriformis Syndrome Diagnosis

2
Filler et al. • J Neurosurg Spine (2005)
Key Findings:
  • MR Neurography shows high signal in nerve at sciatic notch
  • Positive response to Botox injection helps confirm diagnosis
  • Surgery effective in 80% of properly selected cases
Clinical Implication: Use diagnostic injection before considering release.

Injection Palsy Outcomes

3
Pandit et al. • J Bone Joint Surg Br (2002)
Key Findings:
  • Intrafascicular injection causes direct chemical neurotoxicity
  • Pain is the primary warning sign - procedure must be abandoned
  • Surgical exploration within hours does NOT improve outcome
  • Conservative management yields poor results for severe deficits
Clinical Implication: Prevention is the only effective management. Safe zone is critical.

Sciatic Nerve Division Patterns

4
Ugrenovic S et al. • J Anat (2005)
Key Findings:
  • Tibial and common peroneal divisions distinct within gluteal region in 88%
  • High division (at piriformis) in 12%
  • Tibial component located medially and posteriorly
  • Common peroneal more vulnerable due to superficial lateral position
Clinical Implication: Peroneal division is more vulnerable in posterior hip surgery and trauma

Sciatic Nerve Palsy After THA

4
Schmalzried TP et al. • J Bone Joint Surg Am (1991)
Key Findings:
  • Incidence 0.5-2% after primary THA
  • Up to 6% in revision surgery and dysplasia
  • Limb lengthening over 4cm is major risk factor
  • Peroneal division affected in 70% of palsies
  • Full recovery in only 40% of cases
Clinical Implication: Limit lengthening and flex knee post-operatively to reduce nerve tension

Viva Scenarios

Practice these scenarios to excel in your viva examination

VIVA SCENARIOStandard

Scenario 1: Post-THR Foot Drop

EXAMINER

"You perform a posterior approach THR. In recovery, the patient has a foot drop. Take me through your management."

EXCEPTIONAL ANSWER
First, I would ensure the dressing isn't tight (compression). I would examine the patient to differentiate a Sciatic nerve injury (check hamstrings) from a Common Peroneal injury at the knee (pressure sore/positioning). If confirmed sciatic, I would obtain post-op X-rays to ensure the hip is reduced and trial components aren't causing lengthening. If anatomy is fine, it's likely traction neuropraxia. Management is observation, AFO splint, and reassurance. If there is a haematoma on ultrasound/MRI causing compression, I would evacuate it surgically.
KEY POINTS TO SCORE
Rule out compression (dressing/haematoma)
Check leg length (stretch)
Splint (AFO)
COMMON TRAPS
✗Ignoring the dressing
✗Assuming it's permanent
LIKELY FOLLOW-UPS
"How long do you wait for recovery?"
"Expect signs by 3-6 months. If none, EMG dictates next steps."
VIVA SCENARIOStandard

Scenario 2: The Gluteal Injection

EXAMINER

"A nurse calls you. A patient complained of immediate burning pain down the leg during an IM injection. What do you do?"

EXCEPTIONAL ANSWER
This is a medical emergency for the nerve. The injection must be stopped immediately. The needle should be withdrawn. The drug and volume injected must be documented. I would observe the patient. If the pain settles, it may be close proximity. If neurological deficit develops, it suggests intraneural injection. There is no role for immediate surgery 'washing out' unless it's a toxic agent, but even then, damage is instant. Management is supportive with neuropathic pain medication and splinting.
KEY POINTS TO SCORE
Stop Injection
Document Drug
Supportive Care
COMMON TRAPS
✗Attempting to aspirate the drug
✗Immediate surgery (controversial/ineffective)
LIKELY FOLLOW-UPS
"Which quadrant is safe?"
"Upper Outer Quadrant."
VIVA SCENARIOStandard

Scenario 3: Piriformis Syndrome

EXAMINER

"A cyclist complains of deep buttock pain and sciatica. MRI spine is normal. How do you assess for Piriformis Syndrome?"

EXCEPTIONAL ANSWER
This is a diagnosis of exclusion. I would look for tenderness in the sciatic notch (Deep gluteal space). Provocative tests include the FAIR test (Flexion, Adduction, Internal Rotation) which stretches the Piriformis. I would check for Pace's sign (pain on resisted abduction/external rotation). Diagnostic injection of Local Anaesthetic/Steroid into the muscle is the best confirmatory test. If positive, it supports the diagnosis.
KEY POINTS TO SCORE
Diagnosis of Exclusion
FAIR Test
Diagnostic Block
COMMON TRAPS
✗Diagnosing this without MRI spine
✗Operating without a positive block
LIKELY FOLLOW-UPS
"What anatomical variant predisposes to this?"
"Beaton Type B (Common Peroneal through the muscle)."

MCQ Practice Points

Safe Zone

Q: Where is the safe zone for intragluteal injection? A: Upper Outer Quadrant. This avoids the Sciatic Nerve (Lower Medial/Lateral) and Superior Gluteal Nerve (Upper Medial).

Common Peroneal Vulnerability

Q: Why is the Common Peroneal division more susceptible to injury? A: It is lateral, more superficial, and has fewer fascicles with less connective tissue. It is also tethered at the fibular head, reducing its ability to glide during stretch.

Hamstring Innervation

Q: Which hamstring muscle is NOT supplied by the Tibial division? A: Short Head of Biceps Femoris. It is supplied by the Common Peroneal division. This is a key differentiator for high vs low lesions.

Adductor Magnus

Q: What is the innervation of the 'Hamstring portion' of Adductor Magnus? A: Tibial Division of Sciatic Nerve. The adductor portion is supplied by the Obturator Nerve.

Root Value

Q: What are the root values of the Sciatic Nerve? A: L4, L5, S1, S2, S3. It is the largest branch of the sacral plexus.

Australian Context

  • Trauma: Motor vehicle accidents (Posterior Hip Dislocation) are a major cause.
  • Arthroplasty: Australia has a high volume of hip replacements; sciatic palsy is a medicolegal risk. Documentation of pre-op status is mandatory.
  • Guidelines: The AOA guidelines suggest careful retractor placement and awareness of limb lengthening.

High-Yield Exam Summary

Anatomy

  • •Roots: L4-S3
  • •Exit: Greater Sciatic Foramen
  • •Relation: Inf to Piriformis
  • •Divisions: Tibial (Med), CP (Lat)

Clinical

  • •Sign: SLR (Lasègue)
  • •Motor: Hamstrings + All below knee
  • •Reflex: Ankle (S1), Hamstring
  • •Safe Zone: Upper Outer Quadrant

Pathology

  • •Hip Dislocation: 10% Palsy
  • •THR: Traction/Retractor injury
  • •Injection: Chemical neuritis
  • •Piriformis: Compression
Quick Stats
Reading Time51 min
Related Topics

Blood Supply of the Hip

Gluteus Medius Anatomy

Metal-on-Metal Hip Complications

Piriformis Anatomy