SPINAL CORD INJURY
ASIA Classification | MAP 85-90 | No Steroids | Early Surgery
ASIA IMPAIRMENT SCALE
Critical Must-Knows
- ASIA classification is THE standard for neurological assessment in SCI
- MAP 85-90mmHg for 7 days improves outcomes in incomplete SCI
- Methylprednisolone is NOT recommended (NASCIS trials flawed)
- Early surgery (within 24h) for incomplete SCI improves outcomes
- Complete SCI (ASIA A) has poor prognosis regardless of treatment
Examiner's Pearls
- "Neurogenic shock = bradycardia + hypotension (loss of sympathetic tone)
- "Spinal shock = transient areflexia, NOT hypotension
- "Sacral sparing = incomplete injury (better prognosis)
- "Bulbocavernosus reflex return signals end of spinal shock
Clinical Imaging
Imaging Gallery




Critical Spinal Cord Injury Exam Points
ASIA Grading
American Spinal Injury Association scale from A-E. ASIA A = complete (no motor or sensory below level). ASIA B-D = incomplete (sacral sparing present). ASIA B = sensory only. ASIA C = motor less than 3. ASIA D = motor 3 or more.
Neurogenic vs Spinal Shock
Neurogenic shock = cardiovascular (hypotension + bradycardia) from loss of sympathetic tone. Spinal shock = neurological (areflexia below injury level). Spinal shock ends when bulbocavernosus reflex returns.
Methylprednisolone
No longer recommended. NASCIS II/III trials were flawed (post-hoc analysis). Guidelines now recommend AGAINST steroids in SCI. If asked in exam, know the controversy and current stance.
MAP Goals
Maintain MAP 85-90mmHg for 5-7 days in incomplete SCI. This ensures adequate spinal cord perfusion. Use vasopressors (norepinephrine) if needed. Critical for preventing secondary injury.
Quick Decision Guide
| ASIA Grade | Definition | Prognosis | Management Priority |
|---|---|---|---|
| ASIA A (Complete) | No motor/sensory below level | Less than 5% motor recovery | Stabilization, prevent secondary injury |
| ASIA B (Incomplete) | Sensory only, no motor | 50% regain walking ability | Urgent surgery if compression |
| ASIA C (Incomplete) | Motor grade less than 3 | 75% improve one grade | Priority for early decompression |
| ASIA D (Incomplete) | Motor grade 3 or more | 95% maintain walking | Surgery based on instability |
ASIAASIA Impairment Scale
Memory Hook:ASIA A is complete and BAD prognosis. ASIA B-D are incomplete with better outcomes!
SPINALSpinal Shock Signs
Memory Hook:SPINAL shock is neurological (areflexia), NOT cardiovascular - ends when bulbocavernosus returns!
MAPMAP Goals for SCI
Memory Hook:MAP 85-90 for 7 days prevents secondary cord injury from hypoperfusion!
Overview and Epidemiology
Definition
Spinal cord injury (SCI) is damage to the spinal cord resulting in temporary or permanent changes to motor, sensory, or autonomic function below the level of injury. The distinction between complete (ASIA A) and incomplete (ASIA B-E) injuries is crucial for prognosis.
Etiology
Mechanism of Injury:
- Motor vehicle accidents (39%)
- Falls (31%) - increasing in elderly
- Violence (14%) - gunshot wounds predominant
- Sports (8%) - diving injuries common
- Medical/surgical complications (5%)
Level Distribution:
- Cervical (55%) - most common, worst outcomes
- Thoracic (30%) - high velocity injuries
- Lumbar (15%) - often associated with burst fractures
Bimodal Age Distribution
Two peaks: Young adults (15-29 years) from trauma, and elderly (over 65 years) from falls with pre-existing cervical stenosis. The elderly population is growing as a proportion of SCI patients.
Australian Context
Australia has approximately 350-400 new traumatic SCIs per year. The Victorian Spinal Cord Service at Austin Hospital is a major referral center. Transfer protocols with retrieval services are established for early spinal cord center care.
Anatomy and Pathophysiology
Spinal Cord Anatomy
Key Anatomical Points:
- Cord ends at L1-L2 (conus medullaris)
- Cervical cord enlargement (C4-T1) for upper limb
- Lumbar enlargement (L1-S2) for lower limb
- Central grey matter (motor anterior, sensory posterior)
- Peripheral white matter (tracts)
Spinal Cord Tracts
Major Spinal Cord Tracts
| Tract | Function | Location | Clinical Syndrome |
|---|---|---|---|
| Corticospinal (lateral) | Motor - voluntary movement | Lateral column | Weakness below level |
| Spinothalamic (lateral) | Pain and temperature | Anterior-lateral | Contralateral loss |
| Dorsal columns | Proprioception, vibration | Posterior column | Ipsilateral loss |
| Autonomic tracts | Sympathetic/parasympathetic | Intermediolateral | Neurogenic shock |
Pathophysiology of Injury
Primary Injury:
- Mechanical disruption at time of trauma
- Compression, contusion, transection
- Not reversible
Secondary Injury (Preventable):
- Ischemia from hypotension (target MAP 85-90)
- Edema and inflammation
- Excitotoxicity (glutamate release)
- Apoptosis (programmed cell death)
- Occurs over hours to days
Secondary Injury Prevention
The goal of acute SCI management is to prevent secondary injury. This is achieved through: MAP goal 85-90mmHg, early decompression if compressed, avoiding hypoxia, and maintaining normothermia. The primary injury is done - focus on preventing further damage.
Classification
American Spinal Injury Association Impairment Scale
The standard classification for SCI worldwide:
ASIA A - Complete:
- No motor or sensory function in sacral segments S4-S5
- No voluntary anal contraction
- No perianal sensation
- Prognosis: less than 5% regain functional ambulation
ASIA B - Incomplete (Sensory Only):
- Sensory function preserved below level including S4-S5
- No motor function below level
- Prognosis: 50% regain some walking ability
ASIA C - Incomplete (Motor less than 3):
- Motor function preserved below level
- Half of key muscles below level have grade less than 3
- Prognosis: 75% improve at least one ASIA grade
ASIA D - Incomplete (Motor 3 or more):
- Motor function preserved below level
- Half or more of key muscles grade 3 or greater
- Prognosis: 95% maintain community ambulation
ASIA E - Normal: Full motor and sensory function. May have abnormal reflexes.
Clinical Assessment
Primary Survey
- Airway: C-spine controlled, may need intubation
- Breathing: Diaphragm function (C3-5), assess respiratory
- Circulation: Neurogenic shock? Bradycardia, hypotension
- Disability: GCS, pupils, gross neuro
- Exposure: Complete spine exam, log roll
ASIA Examination
- Motor: 10 key muscles bilaterally (0-5 scale)
- Sensory: Light touch + pinprick at 28 dermatomes
- Sacral sparing: Perianal sensation, voluntary anal contraction
- Reflexes: Bulbocavernosus for spinal shock
- Document clearly: Neurological level and ASIA grade
Key Examination Findings
Neurogenic Shock:
- Hypotension (loss of sympathetic vascular tone)
- Bradycardia (unopposed parasympathetic to heart)
- Warm, dry peripheries (vasodilation)
- Occurs with lesions above T6
- NOT the same as spinal shock
Spinal Shock:
- Transient areflexia below injury level
- Flaccid paralysis (even if complete injury)
- Absent bulbocavernosus reflex initially
- Resolves over 24-72 hours typically
- Reflex return signals end of spinal shock
Sacral Sparing = Incomplete Injury
Always check for sacral sparing - perianal sensation and voluntary anal contraction. Any sacral function preserved means incomplete injury (ASIA B or better), which has significantly better prognosis than complete injury.
Investigations
MRI Findings and Prognosis
| MRI Finding | Description | Prognostic Significance |
|---|---|---|
| Hemorrhage | T1 hyperintense, T2 variable | Poor prognosis - irreversible damage |
| Edema only | T2 hyperintense, normal T1 | Better prognosis - may recover |
| Cord transection | Complete cord disruption | Complete injury, no recovery |
| Compression without signal | Mechanical compression, normal cord | Best prognosis if decompressed |
MRI Timing
MRI should not delay resuscitation or surgery in unstable patients. However, for incomplete injuries with unclear pathology, MRI within 24 hours helps guide surgical planning. Hemorrhage on MRI predicts poor outcome regardless of ASIA grade.
Management

Initial Management Priorities
Immobilization:
- Rigid cervical collar until cleared
- Log roll precautions
- Spinal board for transport only (pressure injury risk)
Airway and Breathing:
- Early intubation if GCS impaired or respiratory compromise
- C5 injury and above may need ventilatory support
- Avoid neck extension during intubation (fiber-optic if available)
Circulation - MAP Goals:
- Arterial line for continuous monitoring
- Target MAP 85-90mmHg for 5-7 days
- Vasopressors (norepinephrine first line)
- Avoid hypotension at all costs - causes secondary injury
NO Methylprednisolone: Previously given based on NASCIS trials but now recognized as flawed evidence. Current guidelines recommend AGAINST steroids due to no proven benefit and potential harm (infection, GI bleed).
Surgical Technique
Anterior Cervical Decompression and Fusion
Indications:
- Anterior compression (disc herniation, vertebral body)
- Corpectomy required
- Kyphotic deformity
Technique: Position supine with head in neutral. Approach through Smith-Robinson interval (medial to SCM). Perform discectomy or corpectomy as required. Decompress spinal cord under microscope. Place structural graft or cage. Apply anterior plate. Confirm alignment on fluoroscopy.
Advantages: Direct anterior decompression, restoration of lordosis.
Risks: Recurrent laryngeal nerve, esophageal injury, dysphagia.
Complications
Complications of Spinal Cord Injury
| Complication | Timeframe | Prevention/Management |
|---|---|---|
| Respiratory failure | Acute | Early intubation if C5+, pulmonary toilet |
| DVT/PE | Days to weeks | LMWH + mechanical, IVC filter if needed |
| Pressure ulcers | Days to weeks | Turn q2h, specialty mattress, early mobilization |
| Autonomic dysreflexia | Chronic (T6+) | Identify and remove noxious stimulus |
| Heterotopic ossification | Weeks to months | NSAIDs prophylaxis, radiation if high risk |
| Spasticity | Chronic | Physiotherapy, baclofen, botulinum toxin |
Autonomic Dysreflexia
Medical emergency in chronic SCI above T6. Caused by noxious stimulus below injury (full bladder, constipation). Presents with hypertension, bradycardia, headache, sweating. Treatment: sit upright, identify and remove trigger. May need antihypertensives if severe.
Postoperative Care
Early Rehabilitation
Transfer to spinal rehabilitation unit as soon as medically stable. Multidisciplinary care (physio, OT, psychology, social work) significantly improves functional outcomes. Most neurological recovery occurs in first 6-12 months.
Outcomes and Prognosis
Neurological Recovery
ASIA A (Complete):
- Less than 5% regain functional ambulation
- Recovery plateaus within 1 year
- Focus is on maximizing function at level of injury
ASIA B (Sensory Incomplete):
- 50% regain some walking ability
- Better prognosis than complete injury
- Early surgery may improve outcomes
ASIA C (Motor Incomplete):
- 75% improve at least one ASIA grade
- Most will achieve some ambulation
- Priority for early decompression
ASIA D (Good Motor):
- 95% maintain community ambulation
- Excellent functional prognosis
MRI Hemorrhage = Poor Prognosis
Cord hemorrhage on MRI is the strongest predictor of poor outcome, regardless of initial ASIA grade. Edema without hemorrhage has better recovery potential.
Evidence Base and Key Trials
NASCIS II Trial (National Acute Spinal Cord Injury Study)
- Multicenter RCT: 487 patients with acute SCI
- Methylprednisolone vs placebo vs naloxone
- No primary analysis difference; benefit only in post-hoc subgroup
- Criticized for flawed methodology and multiple post-hoc analyses
STASCIS Trial (Surgical Timing in Acute Spinal Cord Injury Study)
- Prospective cohort: 313 patients with cervical SCI
- Early surgery (less than 24h) vs late surgery (greater than 24h)
- Early surgery: 2x greater odds of 2+ ASIA grade improvement
- Supports early decompression in incomplete injuries
AANS/CNS Guidelines on MAP Targets
- Systematic review of hemodynamic management in SCI
- MAP 85-90 mmHg for first 5-7 days recommended
- Avoids secondary ischemic injury to spinal cord
- ICU-level monitoring required
NASCIS III Trial
- 658 patients with acute SCI
- Extended 48h methylprednisolone if started 3-8h post-injury
- No benefit over 24h; increased complications (pneumonia, sepsis)
- Led to abandonment of steroid protocols
Central Cord Syndrome Prognosis Study
- Systematic review of incomplete SCI recovery
- Central cord syndrome has best prognosis of incomplete injuries
- Upper limb function often improves significantly over 12 months
- Lower limbs and bladder recovery variable
Exam Viva Scenarios
Practice these scenarios to excel in your viva examination
"A 25-year-old male is brought to ED after a diving accident. He has no motor or sensory function below C5 level. His BP is 80/50 and heart rate is 48. How would you manage this patient?"
"A 68-year-old man with known cervical spondylosis falls backwards and presents with weakness affecting his upper limbs more than lower limbs. Describe the syndrome and management."
"Discuss the evidence for and against methylprednisolone in acute spinal cord injury."
MCQ Practice Points
ASIA A Definition Question
Q: What defines an ASIA A spinal cord injury? A: Complete injury with no motor or sensory function below the level, including S4-S5. Less than 5% will regain functional ambulation regardless of treatment timing.
Sacral Sparing Question
Q: What is the clinical significance of sacral sparing after spinal cord injury? A: Sacral sparing indicates incomplete injury (ASIA B or better). Check perianal sensation, deep anal pressure, and voluntary anal contraction. Prognosis is significantly better than complete injury.
Neurogenic vs Spinal Shock Question
Q: What is the difference between neurogenic shock and spinal shock? A: Neurogenic shock = cardiovascular (hypotension + bradycardia from sympathetic loss). Spinal shock = neurological (areflexia and flaccidity below level). They often coexist but are distinct entities.
MAP Goals Question
Q: What is the target MAP in acute spinal cord injury and for how long? A: MAP 85-90 mmHg for 5-7 days to optimize spinal cord perfusion and prevent secondary ischemic injury. Norepinephrine is preferred vasopressor.
Methylprednisolone Question
Q: What is the current recommendation regarding methylprednisolone in acute SCI? A: NOT recommended. NASCIS trials were methodologically flawed with post-hoc analysis only. Current AANS/CNS guidelines recommend against routine steroid use.
Incomplete Syndrome Prognosis Question
Q: Which incomplete SCI syndrome has the best and worst prognosis? A: Best: Brown-Sequard syndrome (90% ambulatory). Worst: Anterior cord syndrome (only 10-20% recovery; only dorsal columns spared). Central cord has intermediate but favorable prognosis.
Australian Context
Epidemiology
- 350-400 new traumatic SCIs per year in Australia
- Main causes: transport (50%), falls (30%)
- Increasing proportion of elderly patients
- Indigenous Australians overrepresented
Healthcare System
- State spinal cord services (Austin Hospital Victoria, POWH NSW)
- Retrieval services for early transfer
- NDIS supports long-term care and equipment
- Spinal Cord Injury Network Australia
Transfer Considerations
Early transfer to specialized spinal cord center improves outcomes. Contact retrieval services early for cervical and complete injuries. Document neurological examination clearly for handover.
SPINAL CORD INJURY
High-Yield Exam Summary
ASIA Classification
- •A = Complete (no motor/sensory S4-S5)
- •B = Sensory only incomplete
- •C = Motor incomplete (less than grade 3)
- •D = Motor incomplete (grade 3+)
- •E = Normal
Neurogenic vs Spinal Shock
- •Neurogenic: Hypotension + bradycardia (cardiovascular)
- •Spinal: Areflexia below level (neurological)
- •Spinal shock ends when bulbocavernosus returns
- •Neurogenic shock occurs with T6 and above injuries
Acute Management
- •MAP 85-90mmHg for 5-7 days
- •NO methylprednisolone (NASCIS flawed)
- •Early surgery within 24h for incomplete SCI
- •DVT prophylaxis essential
Incomplete Syndromes
- •Central cord: UL worse than LL, best prognosis
- •Brown-Sequard: Hemisection, good prognosis
- •Anterior cord: Worst prognosis (dorsal spared)
- •Posterior cord: Rare, proprioception loss
Prognosis by ASIA Grade
- •ASIA A: Less than 5% functional ambulation
- •ASIA B: 50% regain walking
- •ASIA C: 75% improve one grade
- •ASIA D: 95% maintain community walking